DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and alpha-Est1

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	189/572 - (33%)
Similarity:	282/572 - (49%)	Gaps:	109/572 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICL--QRDPFRRDMIL 105
            |..|.::.....||.|:|:|:||:.:||||.|.|..||    |.::|   |.  :..|.::..:|
  Fly    46 RRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPW----LGVRD---CTYPRAKPMQKHFVL 103

  Fly   106 ---EGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFR 167
               ||||||||||||: :|.|::..|||:||.:|||:|.|.....||.||:.:..|:|:|:.|:|
  Fly   104 SIVEGSEDCLYLNVYS-KRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYR 167

  Fly   168 LGPLGFLS--TETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSE 230
            :|.|||||  ...||.|||.|||||:..|.|:..|||.|.|||.::||.|||||.|||...|.:|
  Fly   168 VGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTE 232

  Fly   231 KSRGLLHRGIAQSGTYFNPWA-QPAHKGVAAGR-ATKLAQIVGCGNAGEWPEKLECLRKKPAEDI 293
            ::|||.|:.|.|||:.|..|| :|      :|| |.:||..:|...:....|....|:|.||.::
  Fly   233 QTRGLFHKAIMQSGSMFCEWANEP------SGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEM 291

  Fly   294 VAS-----------LYDMFVWDFDPMIPFPPVVEPEHDGAFLT---VAPR----QAAKPHGLQLP 340
            .|.           .|.:|        ||.|||||     ::|   |.||    ...:..|..||
  Fly   292 AAQGITLVSQEERRQYVLF--------PFTPVVEP-----YITRDCVLPRCHREMLPEAWGNDLP 343

  Fly   341 LMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVL----NYDHHDDSVRQTITQRIESF-- 399
            |::|..:.|||....:.|:..:   ...|.||.::|..:    ...|..|.:||.   ::::|
  Fly   344 LILGGNSFEGLFSYQSTLHDEE---HMLSAFEVLIPREIREKSTQSHLKDLLRQF---KVDNFDD 402

  Fly   400 YFKSGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFD-------HKGAASF 457
            ..:...::::..|     ::|...|..||...:..|:|.....|||:|.||       |     |
  Fly   403 ATRGRMEFNECLH-----ILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNH-----F 457

  Fly   458 TEIFKGGRNEFYGACHAEELQYLFPIGRELFVSAV-PTQKDLELRELMLHLWVSFAKTGNPN--- 518
            .::..|  ....|..||::|.|||   ..:..:.| .:..:.:..:.::.:||:||:..|||
  Fly   458 RQVMCG--KHVRGVSHADDLSYLF---YHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQ 517

  Fly   519 --PTNVSFHLPNWSPASSY-PVEFARLGTKMEDSASIFRLENELMQHRVDFW 567
              ||       .|...... |.....:|.::|     |.:..|..|:|:  |
  Fly   518 IGPT-------TWEALDEKGPQMCLNIGKQLE-----FIVLPESKQNRI--W 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	188/570 (33%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	71/140 (51%)
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	183/549 (33%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	59/116 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760