DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	174/505 - (34%)
Similarity:	246/505 - (48%)	Gaps:	90/505 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRDMIL---EGSEDCLYLNV 116
            ||.|:|||:||:.|||||.|.|..||:|......:     :..|.:|:|:|   |||||||:|||
  Fly    58 AFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTN-----RSKPMQRNMLLGIVEGSEDCLHLNV 117

  Fly   117 YT----PERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTE 177
            |.    .|:|     |||:||.:|||:|.|......|.||:.:...:|.|:.|:||..|||||.:
  Fly   118 YVKALKSEKP-----LPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLK 177

  Fly   178 --TLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGI 240
              .||.|||.|||||:..|.|:..|||.|.||||::|:.|||||.|||...|.:|::|||.|:.|
  Fly   178 DPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAI 242

  Fly   241 AQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDF 305
            .|||...:.|.:....    ..|.:|||.:|.....:..:.|..|.|..|..|.|  .|..|.:.
  Fly   243 MQSGCALSEWVESPDN----NWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAA--IDQDVINL 301

  Fly   306 DP-----MIPFPPVVEP---EHDGAFLTVAPRQ----AAKPHGLQLPLMVGATAEEGLLKTAALL 358
            |.     :..|.||:||   :|     .|.|::    .::..|..:|::||..:.|||.....:.
  Fly   302 DEVRSFLLFAFGPVIEPYETDH-----CVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVR 361

  Fly   359 NLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQT--------ITQRIESFYF-----KSGHDYDKA 410
            ..|..|    ..|..:||         ..||:|        :.:|::..||     :|...::..
  Fly   362 KDPWAL----KNFHNILP---------REVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEAL 413

  Fly   411 N---HQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGA--ASFTEIFKGGRNEFYG 470
            |   |:.:       |.  ....::..|.|.....|||:|.||....  ..|..:..|.|  ..|
  Fly   414 NIFSHRQI-------WH--DTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDR--IRG 467

  Fly   471 ACHAEELQYLF--PIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPN 518
            ..||:||.|||  .|..:|..|::    :.:..|.|:.:|.|||.:||||
  Fly   468 VAHADELSYLFYNIIASKLDKSSM----EYKTIERMVGMWTSFASSGNPN 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	174/505 (34%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	67/143 (47%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	174/505 (34%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	51/108 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760