DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	173/515 - (33%)
Similarity:	261/515 - (50%)	Gaps:	35/515 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRD 102
            |.::|:..|...|....:|..:|||:||:..|||..|:|..||.......|.....||.:.:.:.
  Fly    11 GPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKPLQFNHYSKQ 75

  Fly   103 MILEGSEDCLYLNVYTPE--RPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSAN 165
              |||.|||||||||..|  .||   .||::|:|.|||::.|......:.||:.:..|:|:|:.:
  Fly    76 --LEGVEDCLYLNVYAKELDSPR---PLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVVVVTVS 135

  Fly   166 FRLGPLGFLSTE--TLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHML 228
            :|:|||||||..  .:..|||.||||||..:.|::.|...|.|||.:||.||||||.|||.|.||
  Fly   136 YRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYLML 200

  Fly   229 SEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEK--LECLRKKPAE 291
            :.|:.||.|:.|.|||.....||....|.:    ..:||..:|..:|....:.  |:.|:|.|.|
  Fly   201 NPKAEGLFHKAILQSGNVLCSWALCTIKNL----PHRLAVNLGMESAEHVTDAMVLDFLQKLPGE 261

  Fly   292 DIVASLYDMFVWDF--DPMIPFPPVVEP---EHDGAFLTVAPRQAA-KPHGLQLPLMVGATAEEG 350
            .:|.. |.:...:.  |.:..|.|:|||   ||  ..|...|::.. |..|.::|:::..|:.||
  Fly   262 KLVRP-YLLSAEEHLDDCVFQFGPMVEPYKTEH--CALPNHPQELLDKAWGNRIPVLMSGTSFEG 323

  Fly   351 LLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDKANHQNL 415
            ||..|.:...|.||...|.:.|.:||:.:. .:...::.:.:.||::..:| .|:|....:.::|
  Fly   324 LLMYARVQMAPYLLTSLKKEPEHMLPLDVK-RNLPQALARHLGQRLQETHF-GGNDPSAMSPESL 386

  Fly   416 ---TDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEEL 477
               .:..|...|...|.:.||.|:.... |.||:|.||........:..|...::..|..|.::.
  Fly   387 KAYCEYASYKVFWHPILKTLRSRVKSSS-ASTYLYRFDFDSPTFNHQRLKYCGDKLRGVAHVDDH 450

  Fly   478 QYLFPIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLP---NWSPASS 534
            .||: .|...:.....|.:.|.: |.|:.:..|||:|.|||...:...||   .|.|.:|
  Fly   451 SYLW-YGDFSWKLDKHTPEFLTI-ERMIDMLTSFARTSNPNCKLIQDQLPRAKEWKPLNS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	173/515 (34%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	65/141 (46%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	173/515 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	6	5.860