DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and alpha-Est5

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	168/521 - (32%)
Similarity:	244/521 - (46%)	Gaps:	92/521 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRDMI---LEGSEDCLYLNV 116
            :|..:|:|:|||.:||||.|||..||.|    :.|.....:: |.:|.::   :||.||||||||
  Fly    35 SFEKIPFAKPPLGELRFRAPVPADPWSG----VLDCTHYAEK-PTQRGLLTREIEGGEDCLYLNV 94

  Fly   117 YT----PERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTE 177
            |:    .|:|     |||||:.:||.:..|......||||:.:..|:|||:.|:|:..|||||.:
  Fly    95 YSKQLKSEKP-----LPVMVYIYGGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDCLGFLSLK 154

  Fly   178 --TLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGI 240
              :|..|||.|||||:..|.||:..|::|.||.:::|||||||||.|..:.|.:|::|||.|:.|
  Fly   155 DPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAI 219

  Fly   241 AQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIV----------- 294
            ..|||..|.||    ...|...|.:|||..|.....:..:.||.|:..||.|:|
  Fly   220 PMSGTVHNYWA----NNPAEDFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRR 280

  Fly   295 -------ASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQAAKPHGLQLPLMVGATAEEGLL 352
                   ....:.:|.: |.::|.|||              ..|........|:|:|.|:.|||.
  Fly   281 NGLLFAFGPTVEAYVGE-DCVVPKPPV--------------EMARDAWSNNFPVMLGGTSFEGLF 330

  Fly   353 KTAALLNLPQLLAEFKSQFEQVLPV-VLNYDHHDDSVRQTITQRIESFYFKSGHDYDKANHQ--- 413
            ...|:....:.|........:::|| |.......:::.  .:||:...||    .|...:.:
  Fly   331 MYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLE--YSQRLMKAYF----GYSPPSSELLL 389

  Fly   414 NLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFY--------- 469
            |:.|..|...|..|.:.....|::... ||||.|.||          |......||
  Fly   390 NMLDFYSYKIFWHGFNRTFNARLTYAK-APTYYYRFD----------FDSPNFNFYRAKFCGDKI 443

  Fly   470 --GACHAEELQYLFPIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPA 532
              |..||::|.|||.......:.  .|..:....|.|:.:|.:||.|.|||...:. || .|.|:
  Fly   444 KTGVAHADDLSYLFRNAGSWKLD--KTSAEYRTIERMIGIWTAFAATSNPNCPEIG-HL-EWKPS 504

  Fly   533 S 533
            :
  Fly   505 T 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	168/521 (32%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	66/143 (46%)
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	168/521 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760