DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and alpha-Est6

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	186/548 - (33%)
Similarity:	262/548 - (47%)	Gaps:	75/548 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQR 96
            |:||.|. :.||.|:...|....:|.|:|:|:|||...||.......||..|..|.::.||.||.
  Fly    43 VKLSVGS-VKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPLQM 106

  Fly    97 DPFRRDMILEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVL 161
            |  ||...:.||||||||||||.....:...|||||:.:||.::.|..:.|.||||:|:..|:|.
  Fly   107 D--RRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRDVVY 169

  Fly   162 VSANFRLGPLGFLSTET--LDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVT 224
            |..|:||..|||||..:  ||.|||.||.|||..|.||..:|.:|.|||.::|:||||||.|||.
  Fly   170 VLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVH 234

  Fly   225 YHMLSEKSRGLLHRGIAQSGTYFNPWAQ-PAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKK 288
            :.|...:::||.|:.|..||:..:||.. |...|:..    :||...|.....|....||.||..
  Fly   235 FMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFC----RLATSAGYEGPAEEVPILEFLRNV 295

  Fly   289 PAEDIVASLYDMFVWD----FDPMIPFPPVVEPEHDGAFLTVAPRQ--AAKPHGLQLPLMVGATA 347
            .||.::.  :| |:..    |..:.||.|||      ..|..||.|  ..:....::||::|.|:
  Fly   296 NAEKLIG--HD-FISPRDRCFGFLNPFAPVV------GGLVAAPFQQLMKEAWSCEVPLLLGGTS 351

  Fly   348 EEGL-------LKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGH 405
            .|||       |....:|.|      .|.:...|||..| |.......|.|....:..::: ...
  Fly   352 FEGLVYYPFCQLDNGYMLEL------LKHEPAMVLPHEL-YQSMSVEERNTAADVLVKYHY-GPR 408

  Fly   406 DYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEF-- 468
            ...|:|...:.||.|...|..||...:..|:|... ||||:|.||.....     ....||:.
  Fly   409 GITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQ-APTYLYRFDFDSPK-----LNLMRNQLCG 467

  Fly   469 ----YGACHAEELQYLF--------PIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTN 521
                .|.|||::|.|:|        |:....|::.          :.|:.:..:||:||:||...
  Fly   468 DDIKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTI----------QRMVGILTTFARTGDPNCPE 522

  Fly   522 VSFHLPN-WSPASS-YPVEFARLGTKME 547
            ..   |: |.|.|: .|.:...:|.::|
  Fly   523 TG---PDPWMPVSTKSPFKALNIGQQVE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	183/544 (34%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	65/140 (46%)
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	183/533 (34%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	82/204 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.860