DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	176/510 - (34%)
Similarity:	258/510 - (50%)	Gaps:	87/510 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPIC--LQRDPFRRDMIL---EGSE 109
            |.:..:|.|:|:|:||:.:|||:.||....|       .|...|  ::..|.:.:::|   :|||
  Fly    52 GNNYYSFEGIPFAKPPVGELRFKAPVEPEHW-------SDVKRCTHVRAKPCQVNIVLKQVQGSE 109

  Fly   110 DCLYLNVYT----PERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGP 170
            |||||||||    |.||     |||:||.:|||:|.|......|.||:::...:|||..::|||.
  Fly   110 DCLYLNVYTRELHPHRP-----LPVLVWIYGGGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGA 169

  Fly   171 LGFLS--TETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSR 233
            |||||  .|.||.|||.|||||:..|.||:.|...|||||:::|||||||||||..|.||:::::
  Fly   170 LGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAK 234

  Fly   234 GLLHRGIAQSGTYFNPWAQ-PAHKGVAAGRATKLAQIVG-CGNAGE---WPEKLECLRK---KPA 290
            ||.|:.|..||:...|||| |.|    .....:|||..| .|:|.:   :....:|...   |.|
  Fly   235 GLFHKTIIMSGSALAPWAQTPTH----INWPYRLAQATGYTGDANDRDIFAHLKKCKASSMLKVA 295

  Fly   291 EDIVA--SLYDMFVWDFDPMIPFPPVVEPEHDGAFLT---VAPRQAAKP----HGLQLPLMVGAT 346
            |||:.  ..:....     |..|.|.:||     :||   |.|:...:.    .|..:|:::|..
  Fly   296 EDIITMEERHQRLT-----MFSFGPTIEP-----YLTPHCVIPKSPLEMMRDCWGNSIPMVIGGN 350

  Fly   347 AEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHH-DDSVRQTITQRIESFYF-------KS 403
            :.||||....:...|:||.:. ...|.:.|    .|.| |:..|:...:::...||       |:
  Fly   351 SFEGLLMFPEVNKWPELLCQL-GDCENLAP----QDAHVDEQQRKAFGKKVRELYFGDRTPGRKT 410

  Fly   404 GHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGA-ASFTEIFKGGRNE 467
            ..:|        :||.|..:|..||...|..|.....:|||::|.||.... .:...|...|| :
  Fly   411 ILEY--------SDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGR-K 466

  Fly   468 FYGACHAEELQYLFPIGRELFVSAVPTQK----DLELRELMLHLWVSFAKTGNPN 518
            ..|.|||::|.|||      :.:|....|    :.:..:.::.:.|.||.:|:||
  Fly   467 VRGTCHADDLSYLF------YNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	176/510 (35%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	74/144 (51%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	176/510 (35%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	57/109 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	1	0.950	-	0	Normalized mean entropy	S6088
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.810