DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and Est-Q

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	593	Identity:	181/593 - (30%)
Similarity:	283/593 - (47%)	Gaps:	88/593 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AGLWSIRVILLCICIQWSDGRNSQCLHVRLSHG-GWLIGRH-LTTHNGRHMRAFMGVPYAEPPLD 67
            |||.:..||.| ...|.:|...:..:.|.|.:| |.::|.: .|....|....|.|:|:||||::
  Fly    18 AGLTAFLVIFL-TGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIE 81

  Fly    68 DLRFRPPVPKAPWEGERLAI---KDAPICLQRDPFRRDMILEGSEDCLYLNVYTPERPRTNGSLP 129
            :|||||||.::||.|...|:   :..|:....|....|..|   ||||.|:|||   ...:.|.|
  Fly    82 ELRFRPPVARSPWTGTLNALNFGQRCPVITNLDSQMSDAEL---EDCLTLSVYT---KNLSASQP 140

  Fly   130 VMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVL 194
            ||.:.:|||:..||  |..:.|::||:.|:|||...:|:|.||:|||.|.:.|||..:.|.|..|
  Fly   141 VMFYIYGGGFYNGS--SEDHPPNYLLEKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMAL 203

  Fly   195 HWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKS-RGLLHRGIAQSGTYFNPWAQPAHKGV 258
            .||:.:|:||||||..||:||:|||....:..:||.|: ..:..|.|.|||:.|..||  .:|..
  Fly   204 DWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWA--INKDP 266

  Fly   259 AAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHDGAF 323
            .| ::.::...:||....:..:.::|::|....||:.:....         .|.|:|...|  ..
  Fly   267 KA-QSRRICIQLGCSGCEQHDQLVKCIQKAKVIDILKATASE---------SFSPIVGDLH--GI 319

  Fly   324 LTVAPRQAAKPHGLQLPLMVGATAEEGLLKTAALLN-LPQLLAEFKS----QFEQVLPVVLNYDH 383
            |...|.:..|.:..|:|::.|.|..:|....|:..: |...:|...|    ||.|.:
  Fly   320 LPQQPSELVKSYRRQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGI-------- 376

  Fly   384 HDDSVRQT--ITQRI-ESFYFK----SGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDV 441
             :|.|..|  :|..| ....||    :.||:..| ..:..||.::.:..:.:........:|:..
  Fly   377 -NDLVNDTSGLTDNILNRLLFKPQALNSHDHSAA-VSSYFDLTTNIFMKSPVITLATKMYTQQRS 439

  Fly   442 APTYVYLFDHKGAASFTEIFKGGRNEFY----GACHAEELQYLFPIGRELFVSAVPTQ-KDLELR 501
            .|.|||.|:::|  ::|.......|..|    |..|:.:..|||        :..|.: :|.::.
  Fly   440 TPVYVYSFEYEG--TYTRFGYEFGNSHYPFNGGVHHSNDNIYLF--------ATHPLEGQDTQMS 494

  Fly   502 ELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLG---TKMED-----SASI-----F 553
            :.|:.:|.|||..|.|.         |.||.||....:.:|.   ||.:|     :|:|     .
  Fly   495 QKMVDVWTSFAIEGVPR---------NLSPLSSASGPYNKLNLEVTKGDDLLDTLTAAIDDPDNG 550

  Fly   554 RLENELMQ 561
            ||:.|.|:
  Fly   551 RLQREDME 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	171/562 (30%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	61/138 (44%)
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	168/555 (30%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	49/104 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.860