DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and Nrt

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	128/498 - (25%)
Similarity:	193/498 - (38%)	Gaps:	142/498 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AFMGVPYAEPPLDDLRFRPPV----PKAPWEGERLAIKDAPICLQRDPFRRDMILEGSEDCLYLN 115
            ||.|:|||:||:|.||::|..    ....|.........:.:|.||   ..:....|.||||||:
  Fly   380 AFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQR---LGNGTTVGDEDCLYLD 441

  Fly   116 VYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPD---------FLLDHDIVLVSANFRLGPL 171
            |.|| ..|.|..|||:|..         |..|..||.         :...||::.|..|||||..
  Fly   442 VVTP-HVRYNNPLPVVVLI---------GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVF 496

  Fly   172 GFLSTETL------DCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSE 230
            |||:.:.|      ...||..|.|.:.||:|::.||..|||||.|||:.|..||...||..:.|:
  Fly   497 GFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQ 561

  Fly   231 KSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVA 295
            |.:||..|..|.||:...|....:..|   .:..:|...:.|.:       ::|||:..:|.:.|
  Fly   562 KVKGLYTRAWASSGSAILPGKPLSESG---KQNEQLMATLECAD-------IQCLREASSERLWA 616

  Fly   296 SLYDMFVWDFDPM-IPFPPVVE---PEH-----DGAFLTVAP-----RQAA--KPHGLQLPLMVG 344
            :..|  .|...|: :|.|....   ..|     ||..:...|     |:.|  ||     .|::|
  Fly   617 ATPD--TWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKP-----VLVMG 674

  Fly   345 ATAEE------------------------------GL-------LKTAALLNLPQLLAEFKSQFE 372
            |||.|                              ||       ...::..:|..::::.:|
  Fly   675 ATAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTDEVIEKYNASSYASLVSIISDIRS--- 736

  Fly   373 QVLPVVLN----------------------------------YDHHDDSVRQTITQRIESFYFKS 403
             |.|::.|                                  |:.|....|:.::...:.||:..
  Fly   737 -VCPLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAMQQLFYYYV 800

  Fly   404 GHDYDKANHQNLTDLISDGWFVAGIDEYLRLR-MSQEDVAPTY 445
            .|...::..|| ..:|:.|......::||... ...:|:.|.|
  Fly   801 SHGTVQSFVQN-RRVINVGQDAQPEEDYLPCNYWISKDIVPRY 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	128/498 (26%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	56/152 (37%)
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	125/486 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910