DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and Ces1b

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001074841.1	Gene:	Ces1b / 382044	MGIID:	3779470	Length:	567	Species:	Mus musculus

Alignment Length:	584	Identity:	171/584 - (29%)
Similarity:	269/584 - (46%)	Gaps:	72/584 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCICIQWSDGRNSQCLHVRLSHGGWLIGRHLTTHNGRH-MRAFMGVPYAEPPLDDLRFRPPVPKA 78
            |.:|..|....:|..:.   :..|.::|::.:.....| :..|:|||:|:|||..|||.||.|..
Mouse    11 LALCPIWGHSPSSPVVD---TTQGKILGKYTSLEGFEHPVAVFLGVPFAKPPLGSLRFAPPEPAE 72

  Fly    79 PWEGERLAIKDAPICLQRDPFRRDMILE------------GSEDCLYLNVYTPERPRTNGSLPVM 131
            ||...:.|....|:|.| |.....::.:            .||||||||:|:|.....:..||||
Mouse    73 PWSFVKNATSYPPMCSQ-DAVAVQLLSDMLSTKKESIPPLFSEDCLYLNIYSPADLTKSSLLPVM 136

  Fly   132 VWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHW 196
            ||.||||...| |.|.:.|.......::|:|:..:|||..|..||......||....|||..|.|
Mouse   137 VWIHGGGLMTG-GASLYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQLAALRW 200

  Fly   197 VRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAG 261
            |:.|||:|||:|:||||||.||||.||:..:||..::.|.||.|::|............. ||..
Mouse   201 VQDNIANFGGNPDSVTVFGSSAGGVSVSVLVLSPLAKNLFHRAISESSVVLENIVITLDL-VACD 264

  Fly   262 RATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVW----------DFDPMIPFPPVVE 316
            .:..:|.:.||.:... ...::|||:|...:::.....:.|.          |...|   ..|:
Mouse   265 LSQMIATVSGCNDTSS-TAMVQCLRQKTENELLEITVKLEVTKVGGAASAKKDNTSM---STVI- 324

  Fly   317 PEHDGAFLTVAPRQ-AAKPHGLQLPLMVGATAEE--GLLKTAALLNLPQLLAEFKSQFEQVLPVV 378
               ||..|..||.: .|:.....:|.:||...:|  .::.|.    |..||:|.|.. |:...::
Mouse   325 ---DGVVLPKAPEEILAEKSFSTVPYIVGFNKQEFGWIIPTM----LGDLLSEGKMN-EETASLL 381

  Fly   379 LNYDHHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAP 443
            |...|.|.::.:::...:...|.: |.|........|.|:.||.:|  ||...|..|..::....
Mouse   382 LRRFHSDLNISESLIPAVIEKYLR-GTDDPAKKRDLLLDMFSDVFF--GIPAVLLSRSLRDAGVS 443

  Fly   444 TYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLF--PIGRELFVSAVPTQKDLELRELMLH 506
            ||:|.|.::  .||.   ...|.:.....|.:|:..:|  |:.:|     ..::::..|.::::.
Mouse   444 TYMYEFRYR--PSFV---SDKRPQTVEGDHGDEIFSVFGIPLLKE-----GTSEEETNLSKMVMK 498

  Fly   507 LWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRDL 570
            .|.:||:.||||...    ||:| |.......:.::|...:.:.   ||:.|    .|.||.:|
Mouse   499 FWANFARNGNPNGEG----LPHW-PEYDEKEGYLQIGATTQQAQ---RLKAE----EVAFWTEL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	164/558 (29%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	58/137 (42%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	165/571 (29%)
Ces1b	NP_001074841.1	Aes	<121..>239	CDD:223730	53/118 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810