Protein Alignment CG6414 and AADACL2

DIOPT Version :10

• Sequence 1: NP_570089.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 67/336 - (19%)
• Similarity: 127/336 - (37%)
• Gaps: 85/336 - (25%)

  Fly   114 LNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFL-----LDHDIVLVSANFRLGPLGF 173
            :.:|.|:| ::......:::|||||:..||.....:  |||     ...|.|:|..::||.|...
Human    91 VRLYLPKR-KSETRRRAVIYFHGGGFCFGSSKQRAF--DFLNRWTANTLDAVVVGVDYRLAPQHH 152

  Fly   174 LSTETLDCPGNNGLKDQLEVLHW--VRANIASFGGDPNSVTVFGESAGG---ASVTYHMLSE--- 230
            ...:         .:|.|..:.:  :...:..:|.||..:.:.|:|:||   .:||..:.::
Human   153 FPAQ---------FEDGLAAVKFFLLEKILTKYGVDPTRICIAGDSSGGNLATAVTQQVQNDAEI 208

  Fly   231 ----KSRGLLHRGIAQSGTYFNPWAQPAHK----GVAAGR--ATKLAQIVGC-GNAGEWPEKLEC 284
                |.:.||:.|:..:.:|.     |:|:    |:...|  |.||..:... ..|..|     .
Human   209 KHKIKMQVLLYPGLQITDSYL-----PSHRENEHGIVLTRDVAIKLVSLYFTKDEALPW-----A 263

  Fly   285 LRKK---PAEDIVASLYDMFVWDF-------------DPMI-----PFPPVVEPEHDGAFLTVAP 328
            :|:.   |.|.  ..|:....|..             :|::     ..|.:.:..       ..|
Human   264 MRRNQHMPLES--RHLFKFVNWSILLPEKYRKDYVYTEPILGGLSYSLPGLTDSR-------ALP 319

  Fly   329 RQAAKPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTIT 393
            ..|.......|||....|.:..||:...|:.:.:|         :.:.|.:.::|.:|.:...::
Human   320 LLANDSQLQNLPLTYILTCQHDLLRDDGLMYVTRL---------RNVGVQVVHEHIEDGIHGALS 375

  Fly   394 QRIESFYFKSG 404
            .....||.:.|
Human   376 FMTSPFYLRLG 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_570089.1	COesterase	28..567	CDD:395084	67/336 (20%)
AADACL2	NP_997248.2	Abhydrolase_3	107..372	CDD:400284	61/303 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)