DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and Ces5a

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	165/556 - (29%)
Similarity:	254/556 - (45%)	Gaps:	60/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLSHGGWLIGRHLTTHNGR--HMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ 95
            |.:..||:.|:..|. .||  .:..|:|:|:|.|||..|||..|.|..||...|.|.....:|.|
  Rat    33 RYTRLGWVQGKQATV-LGRLEPVNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTYPNVCFQ 96

  Fly    96 RDPF---RRDMI------LEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGP 151
            ...:   .::::      |..||||||||:|.|........||||:|..|||::.||. |.|.|.
  Rat    97 NLEWLFIYQNLLKVHYPKLGVSEDCLYLNIYAPAYANDGSRLPVMMWIPGGGFETGSA-SIFDGS 160

  Fly   152 DFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGE 216
            ......|:::|:..:|||..||.:|:....|||...:|||..|.|||.||..|||:|:|||:||.
  Rat   161 ALAAYEDVLIVTIQYRLGIFGFFNTQNQHAPGNWAFQDQLAALQWVRENINYFGGNPDSVTIFGG 225

  Fly   217 SAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEK 281
            |||..|::..:||..|.||.||.|.|||....|..:.....:..|... :|.:..| |..:....
  Rat   226 SAGAISISSLILSPLSAGLFHRAIMQSGVAIIPSLKNFDDELKHGLQV-VADVCKC-NVSDSKVL 288

  Fly   282 LECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQAAKPHGLQ-LPLMVGA 345
            |:|||:|.:.::::.        ......|..||    ||:|....|.:.......: :|.::|.
  Rat   289 LKCLREKSSLELLSL--------GQKTKAFTRVV----DGSFFPEEPMELLSQKTFKTVPSIIGV 341

  Fly   346 TAEE-GLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDK 409
            ..:| |.:  ..:...|::|  |.|.....|.::....|........:.:.    ||...|....
  Rat   342 NNQECGYI--LPMREAPEIL--FGSNESTALTLIHVLLHIPPQYMHIVAKD----YFHGKHSLTD 398

  Fly   410 ANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHA 474
            . ...|.||..|.:||  :...:..|..::...|.|.|.|.|:     ...|:..|..|..|.|.
  Rat   399 I-RDTLLDLFGDVFFV--VPGLVTARNHRDAGGPVYFYEFQHR-----PNCFQNTRPAFVKADHT 455

  Fly   475 EELQYLFP---IGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYP 536
            :|::::|.   :..::.:....|:.:..|...|:..|.:||::|:||..:    ||.| ||....
  Rat   456 DEIRFVFGGPFLEGDVVMFEEATEDEKLLSRKMMSYWANFARSGDPNGDD----LPLW-PAYDQN 515

  Fly   537 VEFARLGTKMEDSASIFRLENELMQHRVDFWRDLQP 572
            ..:.:|...:...   :||::    .||:||.|..|
  Rat   516 ESYLKLDVNISTG---WRLKD----RRVEFWTDTLP 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	160/546 (29%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	60/137 (44%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	154/528 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810