DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and Ces2i

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	182/585 - (31%)
Similarity:	256/585 - (43%)	Gaps:	86/585 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RNSQCLHVRLSHGGWLIGRHL-TTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIK 88
            ||:|...||   |.::   |: .|.:|.|  .|:|:|:|:||:..|.|.||....||.|.|....
  Rat    34 RNTQTGQVR---GSFV---HVKDTKSGVH--TFLGIPFAKPPVGPLHFAPPEDPEPWSGVRDGTS 90

  Fly    89 DAPICLQRDPFRRDMILE---------GSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSG 144
            ...:|||.|..:.|.|.|         .||||||||:|||...|...:||||||.||||...||.
  Rat    91 QPDMCLQTDIMKEDFIKEMKLTMHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGLVLGSA 155

  Fly   145 ISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPN 209
             |...........:||:|:..:|||.|||.||......||.|..||:..|.||:.|||.|||:..
  Rat   156 -SMNVASTLAATEEIVIVAIQYRLGILGFFSTGDEHARGNWGYLDQVAALCWVQQNIAYFGGNHG 219

  Fly   210 SVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNP-----WAQPAHKGVAAGRATKLAQI 269
            .||:||.||||.||:.|::|..|:||.|..|.|||....|     .::..:|.|        |.:
  Rat   220 KVTIFGVSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISDTSEVVYKTV--------ANL 276

  Fly   270 VGCGNAGEWPEKLECLRKKPAEDIVA--SLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQ-A 331
            .|| .|.:....:.|||.|..::|:|  .::.|          .|.||    ||.||...|:: .
  Rat   277 SGC-EASDSEALIRCLRAKSKQEILAINQVFKM----------IPGVV----DGKFLPKHPQELL 326

  Fly   332 AKPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRI 396
            |......:|.::|...:|..|.....:.|..::   |......||.||........:.......|
  Rat   327 ASGDFHPVPSIIGVNTDECGLGVPMFMGLDHII---KKITRDTLPTVLKSTAAQMMLPPECIDLI 388

  Fly   397 ESFYFKSGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIF 461
            ...|.....|.:....| ..:::.|..||....|....:.||   ||.|.|.|.|     .....
  Rat   389 MEEYMGDTEDPETLQEQ-FKEMLGDFMFVIPALEVAHFQRSQ---APVYFYEFQH-----LPSFI 444

  Fly   462 KGGRNEFYGACHAEELQYLFPI---GRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVS 523
            |..|.....|.|.:::.::|..   |....:    |:::..|:..::..|.:||:.||||    |
  Rat   445 KQVRPSHVKADHGDDILFVFSSYFWGMNFDI----TEEEELLKRRVMKYWANFARNGNPN----S 501

  Fly   524 FHLPNWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRDLQP----HLPASHA-HNEL 583
            ..||.| |...:..::.:|.|:.       .:...|...|:.||....|    .|..|.: |.||
  Rat   502 EDLPYW-PVLDHNEQYLQLNTQP-------AVGRALKARRLQFWTKTLPQKIQELKGSQSKHAEL 558

Fly 584 583
Rat 559 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	169/551 (31%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	63/142 (44%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	174/562 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910