DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and SPCC417.12

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_588289.2	Gene:	SPCC417.12 / 2539430	PomBaseID:	SPCC417.12	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	537	Identity:	128/537 - (23%)
Similarity:	203/537 - (37%)	Gaps:	122/537 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GWLIGRHLTTHNGRH-MRAFMGVPYAEPPLDDLRFRPPVPKA---PWEGERLAIKDAPICLQRDP 98
            |.|.|..:...||:. ...|.|:.||:||:..||:|.||...   .:.|:....|  .||.|  |
pombe    21 GVLHGLTVLDENGKEKCHRFTGIRYAKPPVGKLRWRRPVTLEDGYDYSGDYNQFK--TICPQ--P 81

  Fly    99 F---RRDMI----LEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFY----GPD 152
            |   |::.:    .:..||||:||::.|...:.....||:.:.|||..|.|:.:  .|    ..|
pombe    82 FYNNRKNQVRNPDFKYDEDCLFLNIWVPAGEKPAEGWPVLYFIHGGWLQVGNPL--HYRQCDPQD 144

  Fly   153 FLLDHD---IVLVSANFRLGPLGFLSTETL--DCP--GNNGLKDQLEVLHWVRANIASFGGDPNS 210
            ...|..   .:|||...||...|||:.:.|  :.|  .|.|..||...|.|...:|.||||:..:
pombe   145 LQADGSPAKFILVSPGHRLNLFGFLAGKELLEEDPKSSNFGFWDQRLGLEWTYKHIESFGGNKEN 209

  Fly   211 VTVFGESAGGASVTYHMLSE----------KSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATK 265
            :.|.|.|||..|..:.::.|          |...||..|::         .||.....:..:..:
pombe   210 IAVGGISAGSYSALFQLIYETYHPEANQIIKRALLLSNGLS---------VQPKSVEESQIQFNE 265

  Fly   266 LAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDF----DPMIPFPPVVEPEHDGAFLTV 326
            |||..|........||||.||..|.:|:..::.::.:..|    |.....|...:..:||.|
pombe   266 LAQKFGIPLELSSAEKLEKLRAIPFQDLADNILNLRLHTFRAVTDGDFVNPNTFKDIYDGTF--- 327

  Fly   327 APRQAAKPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQT 391
              .:..:..|.:  |::|....|..:  .|..|.|:...:..:|.....|             :.
pombe   328 --GKRIRDSGRE--LIIGEVNNEHSI--YANTNPPKSKEDLFNQVNNYYP-------------EK 373

  Fly   392 ITQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDH--KGA 454
            :|:.:...|.|            :.|:..:..::|.|.......:|...|..:...|.:.  ||.
pombe   374 VTKALLELYPK------------VPDMEDEKEYLAAIKALFGSIVSDMQVYASTRVLINGLVKGG 426

  Fly   455 ASFTEIFK---GGRNEFYGACHAEELQYLFPIGRELFVSAVPTQKDLEL-----------RELML 505
            ....:|::   ..|.:|:......|             |.||...||.|           .|:.:
pombe   427 VPLEKIYRYRIAFRGKFFDKYEPPE-------------SLVPHAGDLGLWFYNVVDGILPEEIPI 478

  Fly   506 HL--------WVSFAKT 514
            :.        |:|..||
pombe   479 YKAWLKSYGEWMSTGKT 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	128/537 (24%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	44/158 (28%)
SPCC417.12	NP_588289.2	PnbA	20..534	CDD:225181	128/537 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950