DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and Tg

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	154/574 - (26%)
Similarity:	235/574 - (40%)	Gaps:	144/574 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SDGRNSQCLHVRLSHGGWLIGRHLTTHNG---RHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGE 83
            |||.::..:|:  ...|.|.|.......|   :.:..|:|||||.|||.:.||:.| ....|.|.
  Rat  2194 SDGISTPSVHI--DSFGQLQGGSQVVKVGTAWKQVYQFLGVPYAAPPLAENRFQAP-EVLNWTGS 2255

  Fly    84 RLAIKDAPICLQ---RDPFRRDMILEGSEDCLYLNVYTPERPRTNGSLPVMVWFH--------GG 137
            ..|.|....|.|   |.|....:    |||||||||:.||...:|.|  |:|:||        ||
  Rat  2256 WDATKLRSSCWQPGTRTPTPPQI----SEDCLYLNVFVPENLVSNAS--VLVFFHNTVEMEGSGG 2314

  Fly   138 GWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIA 202
            .......|.:..|       ::::|:||:|||..||||:.:.:..||.||.||:..|.||:.:|.
  Rat  2315 QLNIDGSILAAVG-------NLIVVTANYRLGVFGFLSSGSDEVAGNWGLLDQVAALTWVQTHIG 2372

  Fly   203 SFGGDPNSVTVFGESAGGASVTYHMLSEKSR--GLLHRGIAQSGTYFNPWA--QPAHKGVAAGRA 263
            :|||||..||:..:..|....:.|:|..:..  .|..:.:...|:..:|.|  .|..   |..:|
  Rat  2373 AFGGDPQRVTLAADRGGADVASIHLLITRPTRLQLFRKALLMGGSALSPAAIISPDR---AQQQA 2434

  Fly   264 TKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAP 328
            ..||:.|||.|:.. .|.:.|.|:||| :|:.......:....|...:.|||    ||.:|...|
  Rat  2435 AALAKEVGCPNSSV-QEVVSCFRQKPA-NILNEAQTKLLAVSGPFHYWGPVV----DGQYLRELP 2493

  Fly   329 -RQAAKPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTI 392
             |:..:|..:::.|::|.:.::||:..|..:          .|||:               .|..
  Rat  2494 SRRLKRPLPVKVDLLIGGSQDDGLINRAKAV----------KQFEE---------------SQGR 2533

  Fly   393 TQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASF 457
            |....:||        :|...:|....||...:|....|..|..|.:|.             |||
  Rat  2534 TNSKTAFY--------QALQNSLGGEDSDARILAAAIWYYSLEHSTDDY-------------ASF 2577

  Fly   458 TEIFKGGRNEFYGAC--------------------HAEE------------LQYLFPIGRELFVS 490
            :...:....:::..|                    |..|            :||.|.:.   |.|
  Rat  2578 SRALENATRDYFIICPIVNMASLWARRTRGNVFMYHVPESYGHGSLELLADVQYAFGLP---FYS 2639

  Fly   491 AVPTQKDLELRELMLHL---WVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFAR 541
            |......:|.:.|.|.:   :.:|.::||||                ||.||::
  Rat  2640 AYQGYFSMEEQSLSLKVMQYFSNFIRSGNPN----------------YPHEFSQ 2677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	150/560 (27%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	47/149 (32%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		154/574 (27%)
		COesterase	2198..2719	CDD:278561	151/570 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000