DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	189/618 - (30%)
Similarity:	271/618 - (43%)	Gaps:	125/618 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCICIQWSDGRNSQCLHVRLSHGGWLIGRHL---TTHNGRHMRAFMGVPYAEPPLDDLRFRPPVP 76
            |.:.:|...|::| ...:|.:|.|.:.|..:   .|.:|.|  .|:|:|:|:||:..|||.||..
  Rat    17 LLLLLQHVHGQDS-ASPIRNTHTGQVRGSFVHVKDTKSGIH--TFLGIPFAKPPVGPLRFAPPED 78

  Fly    77 KAPWEGERLAIKDAPICLQRDPFRRDMILE---------GSEDCLYLNVYTPERPRTNGSLPVMV 132
            ..||.|.|.|.....:|||.|....|.|.|         .||||||||:|||...|...:|||||
  Rat    79 PEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMV 143

  Fly   133 WFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWV 197
            |.||||...||. |...........:||:||..:|||.|||.||...:..||.|..||:..|.||
  Rat   144 WIHGGGLVLGSA-SMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLDQVAALRWV 207

  Fly   198 RANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNP-----WAQPAHKG 257
            :.|||.|||:...||:||.||||.||:.|::|..|:||.|..|.|||....|     .::..:|.
  Rat   208 QQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISDKSEVVYKT 272

  Fly   258 VAAGRATKLAQIVGCGNAGEWPEK---LECLRKKPAEDIVA--SLYDMFVWDFDPMIPFPPVVEP 317
            |        |.:.||    |.|:.   :.|||.|..::|:|  .::.|          .|.||
  Rat   273 V--------ANLSGC----EAPDSEALIRCLRAKSKQEILAINQVFKM----------IPGVV-- 313

  Fly   318 EHDGAFLTVAPRQAAKPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYD 382
              ||.||...|::                    ||.:.....:|.::.....:....:||.|..|
  Rat   314 --DGKFLPKHPQE--------------------LLASGDFHPVPSIIGINTDECGWGIPVFLGLD 356

  Fly   383 HHDDSVRQTITQRIESFYFKSG---------------HDY--DKANHQNLTD----LISDGWFVA 426
            |    :.:.||:.......||.               .:|  |..|.:.|.:    ::.|..||.
  Rat   357 H----IIKKITRETLPTVLKSTAAQMMLPPECIDLIMEEYMGDTENPETLQEQFRHMLGDFMFVI 417

  Fly   427 GIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRELF-VS 490
            ...:....:.||   ||.|.|.|.|     .....|..|.....|.|.:::  ||..|..|: ::
  Rat   418 PALQVAHFQRSQ---APVYFYEFQH-----LPSFIKQVRPSHVKADHGDDI--LFVFGSYLWGMT 472

  Fly   491 AVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRL 555
            ...|:::..|:..::..|.:||:|||||..:    ||:| |...:..::.:|.|:.       .:
  Rat   473 FDLTEEEELLKRRVMKYWANFARTGNPNGED----LPHW-PVLDHDEQYLQLNTQP-------AV 525

  Fly   556 ENELMQHRVDFWRDLQP----HLPASHA-HNEL 583
            ...|...|:.||....|    .|..|.: |.||
  Rat   526 GRALKARRLQFWTKTLPQKIQELKGSQSKHAEL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	176/574 (31%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	64/142 (45%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	177/581 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010