DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and CES3

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_079198.2	Gene:	CES3 / 23491	HGNCID:	1865	Length:	571	Species:	Homo sapiens

Alignment Length:	568	Identity:	174/568 - (30%)
Similarity:	250/568 - (44%)	Gaps:	97/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ----RDPFR-----RDMILE 106
            |.:..|:|:|:|:|||...||..|.|..||||.|.|....|:|||    .:..|     :..|..
Human    55 RLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFS 119

  Fly   107 GSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPL 171
            .|||||.||||:|.........|||||.|||....|:. :|:.|.......|:|:|:..:|||.|
Human   120 VSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAA-TSYDGSALAAYGDVVVVTVQYRLGVL 183

  Fly   172 GFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLL 236
            ||.||.....|||.|..|.:..|.||:.|||.||||.|.|||||.||||:.::..:||..:.||.
Human   184 GFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLF 248

  Fly   237 HRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVAS----- 296
            ||.|.|||....|....:|....   |.|:|..:.|.::.. .|.::||::|..|::|.|
Human   249 HRAITQSGVITTPGIIDSHPWPL---AQKIANTLACSSSSP-AEMVQCLQQKEGEELVLSKKLKN 309

  Fly   297 -LYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQAAKPHGL-QLPLMVGATAEE---------G 350
             :|.:.|                 ||.....:|::..|.... .:|.::|....|         |
Human   310 TIYPLTV-----------------DGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWG 357

  Fly   351 LLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDKANHQNL 415
            ||.|...::...:||       ...||:.:.|...:.:...|.:     |..|..| .:|..|..
Human   358 LLDTMEQMSREDMLA-------ISTPVLTSLDVPPEMMPTVIDE-----YLGSNSD-AQAKCQAF 409

  Fly   416 TDLISDGWF---VAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEEL 477
            .:.:.|.:.   ......|||     :..:|.:.|.|.|: .:||.:|    :..:..|.|..|.
Human   410 QEFMGDVFINVPTVSFSRYLR-----DSGSPVFFYEFQHR-PSSFAKI----KPAWVKADHGAEG 464

  Fly   478 QYLF--PI-----GRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNW---SPA 532
            .::|  |.     .|..|..|...:|.|.|  .|:..|..||:||:||    |..||.|   :.|
Human   465 AFVFGGPFLMDESSRLAFPEATEEEKQLSL--TMMAQWTHFARTGDPN----SKALPPWPQFNQA 523

  Fly   533 SSY----PVEFARLGTKMEDSASIFRLENELMQHRVDFWRDLQPHLPA 576
            ..|    ||  .|.|.|..::...|  .:|.:..::..|...|.:..|
Human   524 EQYLEINPV--PRAGQKFREAWMQF--WSETLPSKIQQWHQKQKNRKA 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	171/557 (31%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	61/137 (45%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	170/546 (31%)
		Aes	<129..>247	CDD:223730	52/118 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571		174/568 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910