Protein Alignment CG6414 and Ces2c

DIOPT Version :9

• Sequence 1: NP_001303565.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_663578.1
• Gene: Ces2c / 234671
• MGIID: 2385905
• Length: 561
• Species: Mus musculus
• Alignment Length: 614
• Identity: 189/614 - (30%)
• Similarity: 275/614 - (44%)
• Gaps: 97/614 - (15%)

  Fly     4 DAGLWSIRVILLCICIQWSDGRNSQCLHVRLSHGGWLIGR--HL-TTHNGRHMRAFMGVPYAEPP 65
            :||.:.:  :||.|.:|..|  :.:...:|.:|.|.:.|.  |: .|..|.|  .|:|:|:|:||
Mouse    11 NAGFFGL--LLLLIHVQGQD--SPEANPIRNTHTGQIQGSLIHVKDTKAGVH--TFLGIPFAKPP 69

  Fly    66 LDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRDMILEG--------------SEDCLYLNV 116
            :..|||.||....||.|.|.......:|||    ..||:.|.              ||||||||:
Mouse    70 VGPLRFAPPEAPEPWSGVRDGTAHPAMCLQ----NLDMLNEAGLPDMKMMLSSFPMSEDCLYLNI 130

  Fly   117 YTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDC 181
            |||.......:||||||.|||....|.. |.|.|....::.|:|:|:..:|||.|||.||.....
Mouse   131 YTPAHAHEGSNLPVMVWIHGGALVIGMA-SMFDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDQHA 194

  Fly   182 PGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTY 246
            .||.|..||...|.||:.|||.|||:|:.||:|||||||.||:.|::|..|:||.|..|.:||..
Mouse   195 RGNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVA 259

  Fly   247 FNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVA--SLYDMFVWDFDPMI 309
            ..|   ......:...:|.:|::.|| .|.:....:.|||.|...:|:|  .::.|
Mouse   260 LLP---DLISETSEMVSTTVAKLSGC-EAMDSQALVRCLRGKSEAEILAINKVFKM--------- 311

  Fly   310 PFPPVVEPEHDGAFLTVAPRQAAKPHGLQ-LPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQ 373
             .|.||    ||.|....|::........ :|.::|...:|.......::...|::   |....:
Mouse   312 -IPAVV----DGEFFPRHPKELLASEDFHPVPSIIGVNNDEFGWSIPVVMGSAQMI---KGITRE 368

  Fly   374 VLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDY--DKANHQNL----TDLISDGWFVAGIDEYL 432
            .|..||.    |.:|:..:.........:   :|  |..:.|.|    |:::.|..||.   ..|
Mouse   369 NLQAVLK----DTAVQMMLPPECSDLLME---EYMGDTEDAQTLQIQFTEMMGDFMFVI---PAL 423

  Fly   433 RLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPI---GRELFVSAVPT 494
            ::...|...||.|.|.|.|.     ...||..|.....|.||:|:.::|..   |.:|..    |
Mouse   424 QVAHFQRSHAPVYFYEFQHP-----PSYFKDVRPPHVKADHADEIPFVFASFFWGMKLDF----T 479

  Fly   495 QKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENEL 559
            :::..|...|:..|.:||:.||||    |..||.| |...:..::.:|..:.       .:...|
Mouse   480 EEEELLSRRMMKYWANFARHGNPN----SEGLPYW-PVMDHDEQYLQLDIQP-------AVGRAL 532

  Fly   560 MQHRVDFWRDLQP----HLPASH-AHNEL 583
            ...|:.||....|    .|.||. .|.||
Mouse   533 KAGRLQFWTKTLPQKIQELKASQDKHREL 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	172/559 (31%)
		Aes	<116..>254	CDD:223730	63/137 (46%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	173/567 (31%)
		Aes	<130..>233	CDD:223730	49/103 (48%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810