Protein Alignment CG6414 and NLGN1

DIOPT Version :10

• Sequence 1: NP_570089.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 186/612 - (30%)
• Similarity: 267/612 - (43%)
• Gaps: 142/612 - (23%)

  Fly    56 FMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ-----RDP-------FRRDM----- 103
            |:|||||.||..:.||:||.|.:||...|.|.:.||:|.|     |.|       |..::
Human    80 FLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSS 144

  Fly   104 -ILEGSEDCLYLNVYTP--ERPRT---------------------NGSLPVMVWFHGGGWQCGSG 144
             :.:.||||||||:|.|  :.|.|                     .|..||||:.|||.:..|:|
Human   145 YVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTG 209

  Fly   145 ISSFYGPDFLLDH-DIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDP 208
              :.|....|..: ::::::.|:|||.||||||......||.||.|.::.|.|...||..|||||
Human   210 --NLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDP 272

  Fly   209 NSVTVFGESAGGASVTYHMLSEKS---------RGLLHRGIAQSGTYFNPWA---QPAHKGVAAG 261
            ..:||||..|||:.|....||..|         :||..|.||||||..:.||   |||.
Human   273 LRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAK------ 331

  Fly   262 RATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPM---IPFPPVVEPEHDGAF 323
            .|..||..||| |..:..|.:|||:|||.:::|..       |..|.   |.|.||:    ||..
Human   332 YARMLATKVGC-NVSDTVELVECLQKKPYKELVDQ-------DIQPARYHIAFGPVI----DGDV 384

  Fly   324 LTVAPRQAAKPHG--LQLPLMVGATAEEGLLKTAALLNLPQLL--AEFKSQFEQVLPVVLNYDHH 384
            :...| |.....|  |...:|:|....|||.....:::....:  ::|.......:..:..|...
Human   385 IPDDP-QILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEG 448

  Fly   385 DDSVRQTITQRIESFYFKSGHD--YDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDV-----A 442
            .|.:|:||     .|.:....|  ..:...:.|..|.:|..:||.       .::..|:     :
Human   449 KDVLRETI-----KFMYTDWADRHNPETRRKTLLALFTDHQWVAP-------AVATADLHSNFGS 501

  Fly   443 PTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPI----GRELFVSAVP---TQKDLEL 500
            |||.|.|.|.........:.       .|.|.:|:.|:..|    ..|||    |   ::.|:.|
Human   502 PTYFYAFYHHCQTDQVPAWA-------DAAHGDEVPYVLGIPMIGPTELF----PCNFSKNDVML 555

  Fly   501 RELMLHLWVSFAKTGNPN---PTNVSF-HL-PN------WSPASSYPVEFARLGTKMEDSASIFR 554
            ..:::..|.:|||||:||   |.:..| |. ||      |:..|.....:..:|.|.       |
Human   556 SAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKP-------R 613

  Fly   555 LENELMQHRVDFWRDLQPHLPASHAHN 581
            ::.....::|:.|.:|.|||     ||
Human   614 VKEHYRANKVNLWLELVPHL-----HN 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_570089.1	COesterase	28..567	CDD:395084	179/596 (30%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	179/596 (30%)