Protein Alignment CG6414 and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_570089.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 175/608 - (28%)
• Similarity: 266/608 - (43%)
• Gaps: 137/608 - (22%)

  Fly    56 FMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFR---RDM-------------- 103
            ::|||||.||..:.||:||...:.|.|.|.|.:.:.:|.|....|   .||
Human    73 YLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMT 137

  Fly   104 -ILEGSEDCLYLNVYTPERPRT-----------------------NGSLPVMVWFHGGGWQCGSG 144
             :.:.:|||||||:|.|....|                       |...||||:.|||.:..|:|
Human   138 YVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEGTG 202

  Fly   145 ------ISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIAS 203
                  |.:.||       ::::::.|:|||.||||||......||.||.||::.|.|:..|:.:
Human   203 NMIDGSILASYG-------NVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGA 260

  Fly   204 FGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA---QPAHKGVAAGRATK 265
            |||||..||:||..||.:.|:...||..|.||..:.|.||||..:.||   |||       :.|:
Human   261 FGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPA-------KYTR 318

  Fly   266 -LAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPR 329
             ||..||| |..:..:.:|||:.|..::::........:.    |.|.||:    ||..:...|
Human   319 ILADKVGC-NMLDTTDMVECLKNKNYKELIQQTITPATYH----IAFGPVI----DGDVIPDDP- 373

  Fly   330 QAAKPHG--LQLPLMVGATAEEGLLKTAALLN-----LPQLLAEFKSQFEQVLPVVLNYDHHDDS 387
            |.....|  |...:|:|....|||.....:::     .|.   :|.......:..:..|....|:
Human   374 QILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPN---DFDFSVSNFVDNLYGYPEGKDT 435

  Fly   388 VRQTITQRIESFYFKSGHDYD--KANHQNLTDLISDGWFVAGIDEYLRLRMSQEDV-----APTY 445
            :|:||     .|.:....|.:  :...:.|..|.:|..:||.       .::..|:     :|||
Human   436 LRETI-----KFMYTDWADKENPETRRKTLVALFTDHQWVAP-------AVATADLHAQYGSPTY 488

  Fly   446 VYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPI----GRELFVSAVPTQKDLELRELMLH 506
            .|.|.|...:..       :..:..:.|.:|:.|:|.|    ..||| |...::.|:.|..:::.
Human   489 FYAFYHHCQSEM-------KPSWADSAHGDEVPYVFGIPMIGPTELF-SCNFSKNDVMLSAVVMT 545

  Fly   507 LWVSFAKTGNPN---PTNVSF-HL-PN------WSPASSYPVEFARLGTKMEDSASIFRLENELM 560
            .|.:|||||:||   |.:..| |. ||      ||..:.....:..:|.|.       |:.:...
Human   546 YWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-------RVRDHYR 603

  Fly   561 QHRVDFWRDLQPHLPASHAHNEL 583
            ..:|.||.:|.|||   |..||:
Human   604 ATKVAFWLELVPHL---HNLNEI 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_570089.1	COesterase	28..567	CDD:395084	166/590 (28%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	166/590 (28%)