Protein Alignment CG6414 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_570089.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 611
• Identity: 186/611 - (30%)
• Similarity: 264/611 - (43%)
• Gaps: 147/611 - (24%)

  Fly    56 FMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRDMILEG------------- 107
            |:|||||.|||...||:||...|.|.|.|.|....|.|.|.        |.|
Mouse    69 FLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQN--------LHGALPAIMLPVWFTD 125

  Fly   108 ------------SEDCLYLNVYTPERP-------------------RTNGSLPVMVWFHGGGWQC 141
                        ||||||||:|.|...                   |.:|..|||::.|||.:..
Mouse   126 NLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYME 190

  Fly   142 GSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGG 206
            |:| :.|.|.......::::|:.|:|||.||||||......||.||.||::.|.|:..|||.|||
Mouse   191 GTG-NMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGG 254

  Fly   207 DPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA---QPAHKGVAAGRATK-LA 267
            ||..:|:||..||.:.|...:||..|.||..:.||||||..:.|:   ||.       :.|: ||
Mouse   255 DPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPL-------KYTRLLA 312

  Fly   268 QIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPM---IPFPPVV-------EPE---H 319
            ..||| :..:..|.:||||:|.:.::|..       |..|.   |.|.|||       :||   .
Mouse   313 AKVGC-DREDSTEAVECLRRKSSRELVDQ-------DVQPARYHIAFGPVVDGDVVPDDPEILMQ 369

  Fly   320 DGAFLTVAPRQAAKPHGLQLPLMVGATAEEGL--LKTAALLNLPQLLAEFKSQFEQVLPVVLNYD 382
            .|.|             |...:::|....|||  ::.:|........:.|.......:..:..|.
Mouse   370 QGEF-------------LNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYP 421

  Fly   383 HHDDSVRQTITQRIESFYFKSGHDYD--KANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTY 445
            ...|.:|:||     .|.:....|.|  :...:.|..|.:|..:||......:|....:  :|.|
Mouse   422 EGKDVLRETI-----KFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQ--SPVY 479

  Fly   446 VYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPI----GRELFVSAVP---TQKDLELREL 503
            .|.|.|...|.       ||.|:..|.|.:||.|:|.:    ..:||    |   ::.|:.|..:
Mouse   480 FYTFYHHCQAE-------GRPEWADAAHGDELPYVFGVPMVGATDLF----PCNFSKNDVMLSAV 533

  Fly   504 MLHLWVSFAKTGNPN---PTNVSF-HL-PN------WSPASSYPVEFARLGTKMEDSASIFRLEN 557
            ::..|.:|||||:||   |.:..| |. ||      ||..:|...::..:|.|.       |:.:
Mouse   534 VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKP-------RVRD 591

  Fly   558 ELMQHRVDFWRDLQPHLPASHAHNEL 583
            ....::|.||.:|.|||  .:.|.||
Mouse   592 NYRANKVAFWLELVPHL--HNLHTEL 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_570089.1	COesterase	28..567	CDD:395084	177/593 (30%)
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	177/593 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836