DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and Ces2e

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	188/634 - (29%)
Similarity:	276/634 - (43%)	Gaps:	141/634 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DAGLWSIRVILLCIC-IQWSDGRNSQCLHVRLSHGGWLIGRHL---TTHNGRHMRAFMGVPYAEP 64
            :|.:|.   :||..| :|..|..:.    :|.:|.|.:.|..:   .|.:|.|  .|:|:|:|:|
  Rat    11 NAVVWG---LLLLFCQVQGQDSASP----IRNTHTGQVRGSFVHVKDTKSGVH--TFLGIPFAKP 66

  Fly    65 PLDDLRFRPPVPKAPWEGERLAIKDAPICLQ---------------RDPFRRDMILEGSEDCLYL 114
            |:..|||.||.|..||.|.|.......:|||               |.|      :..|||||||
  Rat    67 PIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSP------VSMSEDCLYL 125

  Fly   115 NVYTPERPRTNGSLPVMVWFHGGG--WQCGSGISSFYGPDFLLD-HDIVLVSANFRLGPLGFLST 176
            ::|||.....:.:||||||.||||  |    |::|.|....|.. .|:|:|:..:|||.|||.||
  Rat   126 SIYTPAHTHKDSNLPVMVWIHGGGLCW----GMASTYDGSMLAAIEDVVVVTIQYRLGILGFFST 186

  Fly   177 ETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIA 241
            ......||.|..||:..|.||:.||..|||:|:.||:|||||||.||:.|::|..|:||.|..|.
  Rat   187 GDEHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIM 251

  Fly   242 QSGTYFNPWAQPAHKGVAAGRA----TKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFV 302
            :||....|       .:.:..:    |.:|.:.|| ...:....:.|||:|..|:::|  .:..|
  Rat   252 ESGVALLP-------NLISNTSEVIYTMVANLSGC-EPVDSEALMSCLREKSEEEMLA--INNIV 306

  Fly   303 WDFDPMIPFPPVVEPEHDGAFLTVAPRQAAKPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEF 367
            .....::          ||.||   ||     |.|:            ||.:.....:|.::...
  Rat   307 RTISGVV----------DGKFL---PR-----HPLE------------LLASVDFHPVPSIIGIN 341

  Fly   368 KSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKS--------------------GHDYDKANH 412
            ..::..::|::     |.||..:.|.:.......|:                    |...|....
  Rat   342 SDEYGWIIPML-----HPDSTMKEINRETMRAVLKNTAVQMMLPPECSDLLMEEYMGDTEDSKTL 401

  Fly   413 Q-NLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEE 476
            | ...:::.|..||.   ..|::...|...||.|.|.|.|:     :...|..|.....|.|.:|
  Rat   402 QIQFNEMMGDFIFVI---PALQVAHFQRSHAPVYFYEFQHQ-----SNFLKDIRPPHVKADHGDE 458

  Fly   477 LQYLFPIGRELF--VSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEF 539
            |.|:  || .||  :..|.|:::..|...|:..|.:||:.||||    |..||.| ||..:..::
  Rat   459 LPYV--IG-YLFWDMKFVFTEEEKLLSRKMIKYWANFARHGNPN----SEGLPYW-PALDHDEQY 515

  Fly   540 ARLGTKMEDSASIFRLENELMQHRVDFWRDLQP----HLPASH-AHNEL 583
            .:|     |...:  :...|...|:.||....|    .|..|. .|.||
  Rat   516 LQL-----DIQPV--VGRALKARRLKFWTKTLPQKIQELKGSQDNHTEL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	172/578 (30%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	64/140 (46%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	173/589 (29%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	50/106 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810