DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and cest-31

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_504692.3	Gene:	cest-31 / 187304	WormBaseID:	WBGene00019653	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	160/566 - (28%)
Similarity:	252/566 - (44%)	Gaps:	76/566 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NSQCLHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDA 90
            ||.|..|:         .:|..|....:..::|:|||:||:..|||:.||....|...|...|..
Worm    18 NSTCGPVQ---------GNLYRHGNEEVHGYLGIPYAQPPIGILRFKKPVSADVWTETRDCTKYG 73

  Fly    91 PICLQRDPFRRDMILEGSE-----DCLYLNVYTPE-RPRTNGSLPVMVWFHGGGWQCGSGISSFY 149
            |.|........::.|..::     :||.|||:.|: ..:.:...|||::.||||::..:  |..|
Worm    74 PRCPPSGMLYENLQLPNTDIPDEANCLSLNVFCPQWEIKQSAKHPVMIFIHGGGFELSA--SKDY 136

  Fly   150 GPDFLLD-----HDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPN 209
             .|:.|.     .|:::|:.|:|:|.||||:|....|.||.||.|....|.||..:|:||||||.
Worm   137 -CDYSLSGTLPLKDVIVVTVNYRVGALGFLTTGDDSCRGNFGLWDLTLALKWVSTHISSFGGDPK 200

  Fly   210 SVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA--QPAHKGVAAGRATKLAQIVGC 272
            :||:||:|||........||..||.|.|:.|..||:...|:|  ...::.:......:.....|.
Worm   201 NVTLFGQSAGAVCADLLNLSPYSRDLFHKLIIMSGSAHVPFAIRTEENQALVCMEYARSRGFSGS 265

  Fly   273 GNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQAAKPHGL 337
            |:|    |.||.....|.|.::...........|  :.|.|.:    ||.|.. .|.:..:....
Worm   266 GSA----ELLEFFENLPIEKLLEKTGLKHTVSID--LSFAPNL----DGDFFP-KPLEELRRETR 319

  Fly   338 QLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVR--QTITQRIESFY 400
            :.|::||...:|||:...|..:.......||.:.|.        ::..|.|.  :.:.:.|.:||
Worm   320 KKPVIVGMMEDEGLITAFADGDFTTCEENFKRRVES--------EYRGDVVENPENVQKNIMNFY 376

  Fly   401 FKSGHDY-DKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAP----TYVYLFDHKGAASFTEI 460
                .:| |::..:.|.|.|....:.||:      .:|.|.:|.    .|.|:||......|..:
Worm   377 ----TNYCDESEERKLVDYIGHSVYNAGV------LLSAESLARAGNCVYFYVFDFWNPDGFGPV 431

  Fly   461 FKGGRNEFYGACHAEELQYLFPIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFH 525
              |....|.||.|..||:|:  ||..::......:|||::.|.|..::.:|||.||||...|:
Worm   432 --GSIVPFKGAAHCSELRYI--IGEGVYSKFDANEKDLKMMEYMTTMFTNFAKYGNPNIPGVT-- 490

  Fly   526 LPNWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRDLQ 571
              ||...:.....|....|..|       :::...::|..|.:.:|
Worm   491 --NWETYTEGSRHFHIDSTDSE-------MKDSFQENRCQFLKQIQ 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	154/550 (28%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	57/145 (39%)
cest-31	NP_504692.3	COesterase	16..522	CDD:278561	158/559 (28%)
cest-31	NP_504692.3	Aes	<112..>211	CDD:223730	43/101 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I1491
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.710