DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and cest-13

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_741921.1	Gene:	cest-13 / 181493	WormBaseID:	WBGene00010116	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	141/511 - (27%)
Similarity:	210/511 - (41%)	Gaps:	107/511 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AFMGVPYAEPPLDDLRF---RPPVPKAPWEGERLAIKDAPICLQRDPFRRDMILEGSEDCLYLNV 116
            :|.|:.||:||:...||   |...|....|.:..    ..||:|.|.      ....||||::||
Worm    46 SFRGIRYAQPPVGLFRFGAARRLDPVGLVEAQAY----GNICVQGDG------RTSHEDCLFINV 100

  Fly   117 YTPERPRTNGSLPVMVWFHGGGWQCGSG-ISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLD 180
            |||........|||.|:.||||:..|.| :.:...|:.:....||:||.|:||||.||.||..:.
Worm   101 YTPNNVTQASKLPVYVYIHGGGFVEGGGNMGAGIYPNLVNKGPIVMVSINYRLGPFGFFSTRQMT 165

  Fly   181 CPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGT 245
            .|||..:.|.:|.|:||:..|:.||||||.||:.|:|:|..:|:...|:..::.|..:.|.:||:
Worm   166 APGNWAISDWIEALNWVQRYISFFGGDPNRVTIGGQSSGAEAVSTLTLTPLAKNLFKQSIHESGS 230

  Fly   246 YFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEK------LECLRKKPAEDIVASLYDMFVWD 304
            .|.. |..::.......:.:|:..:||..:.:|...      |.|||....:.|||:
Worm   231 AFGA-AVMSYSEKTRSTSKQLSIKLGCATSDQWDNGQSFGTILTCLRNVTYDKIVAA-------- 286

  Fly   305 FDPMIPFP----PVVEPEHDGAFLTVAPRQAAKPHGLQLPLMVGATAEE--GLLKTAALLNLPQL 363
             |..:|..    .:|:   |..:||......|.....:..:::|...:|  |......|.|
Worm   287 -DNSLPGHRMKWSIVQ---DNKYLTQRLEYLALQRDPKKNVLIGDVHDEWLGWEMNNVLHN---- 343

  Fly   364 LAEFKSQFEQVLPVVLNYDHH------DD---SVRQTITQRIESFYFKSGHDYDKANHQNLTDLI 419
                           :|..|:      ||   |...|.....:|....:.:.|  .|:|..||..
Worm   344 ---------------INSSHNTAHQMRDDLSGSYEMTYWDNKQSVLVAADNKY--INNQGWTDDN 391

  Fly   420 SDGWFVAGIDEYLRLRMSQEDV--APT--------------YVYLFDHKGAASF----TEIFKGG 464
            ...|      |..|:::..|.|  .||              |:|..|.....:.    ..:|:|
Worm   392 HREW------EARRIQLWSEMVFIGPTLRDAAYFQYMKNNVYLYSLDWLSPPALPLVTDPLFRG- 449

  Fly   465 RNEFYGAC-HAEELQYLFPIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNP 519
                   | |..||||:|......|..   |.:|..||......|::|...|||.|
Worm   450 -------CEHTWELQYIFSTSCNGFTC---TAQDEILRNYFTTTWLNFIIGGNPTP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	141/511 (28%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	56/138 (41%)
cest-13	NP_741921.1	Abhydrolase	22..510	CDD:304388	141/511 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010