DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and cest-34

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001360105.1	Gene:	cest-34 / 179057	WormBaseID:	WBGene00019652	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	166/576 - (28%)
Similarity:	258/576 - (44%)	Gaps:	79/576 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NSQCLHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDA 90
            |:.|        |.::| :|..|..:.:..::|:|||:||..::||..|||...|...|...|..
Worm    18 NTSC--------GPVLG-NLYRHGDKEVHGYLGMPYAKPPTGEMRFAKPVPADDWTETRDCTKYG 73

  Fly    91 PICLQRDP----FRRDMILEGSE----DCLYLNVYTP--ERPRTNGSLPVMVWFHGGGWQ----- 140
            |.|   .|    ..:.|.:...|    :.|.:||:.|  |......:.||||:.||||::
Worm    74 PRC---PPSGQGLEKGMFVNPDEPDEANGLSVNVFVPGWESSEYKNARPVMVYVHGGGFEISSSR 135

  Fly   141 --CGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIAS 203
              |...|||     .|...|::||:.|:|||.|||.:|....||||.||.||...|.||:.:|||
Worm   136 EFCDYSISS-----TLPMKDVILVTMNYRLGILGFFTTGDEVCPGNFGLWDQTLALQWVQKHIAS 195

  Fly   204 FGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQ 268
            ||||||:||:||:|||||.|....||..||.|..:.:..||:....:|....:..|......||:
Worm   196 FGGDPNNVTLFGQSAGGACVDLLTLSPHSRDLFQKVVPMSGSAMCEFAMRTAENEAHVFDDILAR 260

  Fly   269 IVGCGNAGEWPEKLECLRKKPAEDIVASL-YDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQAA 332
            :...|:..:  |:||.:|..|.:.|.... |......|..:.       |.:||.|.. .|....
Worm   261 LGFTGSGSK--ERLEFMRSLPCDKITGKTGYTYKQSGFMSLC-------PNYDGDFFP-KPLDEL 315

  Fly   333 KPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVR--QTITQR 395
            :....:..||.|....|||| .|...|.|.      ..:..:|.:.:..|:.:|.|.  :.|.:.
Worm   316 RKDASKRILMTGIVGNEGLL-FAFDRNTPY------KDYTDLLRLKIEEDYKEDVVDDVEGIRKE 373

  Fly   396 IESFYFKSGHDYD-KANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVA----PTYVYLFDHKGAA 455
            |..:|.|:..:.| :|..:...:.:.|..|..|:      |.:.::.|    ..::|.||:....
Worm   374 IFEYYTKNISEGDEEAIMRKAAEFVGDSIFHTGV------RATAQNAAEHGDEVWLYNFDYCNPD 432

  Fly   456 SFTEIFKGGRNEFYGACHAEELQYLFPIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPT 520
            .|..:  .|...:....|..||:|||  |..:.....||:::|::.:....::.:|||.||||.|
Worm   433 GFAPL--KGYLPYIEPTHGMELRYLF--GDGIISKFEPTEEELKMLDKFTTMFANFAKYGNPNET 493

  Fly   521 NVSFHLPNWS------PASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRDL 570
            ..|    .|.      |...|.:.:...|.:.|.|...::...|:.:....|.:::
Worm   494 GSS----AWEKFDPARPGRHYRISYPNSGMEDEFSGGRWKFLEEIRKKNKSFQQNV 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	163/561 (29%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	65/146 (45%)
cest-34	NP_001360105.1	COesterase	15..530	CDD:365897	164/559 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I1491
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14726
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.710