DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and cest-35.2

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_504398.1	Gene:	cest-35.2 / 178910	WormBaseID:	WBGene00016863	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	586	Identity:	156/586 - (26%)
Similarity:	248/586 - (42%)	Gaps:	113/586 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NSQCLHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDA 90
            |:.|..:|         .::..|..:.:..::|:|:|:.|:.||||:..|....|.......|..
Worm    18 NASCGPIR---------GNVYEHGDKIVNGYLGIPFAKAPIGDLRFKKSVEAEKWTQPLDCYKYG 73

  Fly    91 PICLQRDPFRRDMILEGS------EDCLYLNVYTP-----ERPRTNGSLPVMVWFHGGGWQCGSG 144
            |.|.|.......|:.:.:      ::||.|||:.|     |.|  || .||||:|:|||::.  |
Worm    74 PGCPQSAALGALMVSQATNHDFAEDNCLNLNVFAPKWKSAEFP--NG-FPVMVYFYGGGFEV--G 133

  Fly   145 ISSFYGPDFLLD-----HDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASF 204
            .||.: .|:.|.     .|::||:.|:|:|||||.:|......||.||.||...|.||:.:|.||
Worm   134 FSSMF-DDYSLTGTLPLKDVILVTPNYRIGPLGFFATGDDVARGNWGLWDQALALQWVQKHIKSF 197

  Fly   205 GGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGT---------------YFNPWAQPA 254
            ||||::||:.|.|||||||.:..||..:.....:.|..||.               .|..:|.
Worm   198 GGDPSNVTISGTSAGGASVDFLSLSPHANKYFQKFIPMSGAATCPFGIRSKDVEGLIFREFAN-- 260

  Fly   255 HKGVAAGRATKLAQIVGCGNAGEW--PEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEP 317
            |.|.....:..|.|         |  .:..|...|.......||....||              |
Worm   261 HHGYTGNDSKSLLQ---------WYQSQDSEIFLKAEGYKCPASGMFSFV--------------P 302

  Fly   318 EHDGAFLTVAPRQAAKPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVL------P 376
            ..||.|.. .|....:....:|..:|.....||       |......|..|:. :|:|      .
Worm   303 NFDGDFFP-KPFDELRKEAPKLGAIVSIGEYEG-------LGFEDFYAGQKTP-QQMLSAALGPE 358

  Fly   377 VVLNYDHHDDSVRQTITQRIESFYFKSGHDYDKAN-HQNLTDLISDGWFVAGIDEYLRLRMSQED 440
            ||.|        |:.:.:|....|.|:|.:.::.| .:.|.::..|.:|..|..:.:|..:...:
Worm   359 VVRN--------REEVVKRAAESYLKNGGNENEENIAKTLVEIFGDYYFSVGAFDTVRSLVKYGN 415

  Fly   441 VAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRELFVSAVPTQKDLELRELML 505
            .  .|:|.|::....  |.|..|....|..|.|..:|:|:|..|...|     :::|.::.::|.
Worm   416 T--VYLYSFNYFNPN--TPIVFGKNRPFNAANHGSDLRYIFGEGTGEF-----SKEDRQVMDMMG 471

  Fly   506 HLWVSFAKTGNPNPTNVSFHLPNWS---PASSYPVEFARLGTKMEDS--ASIFRLENELMQHRVD 565
            ....:|||.||||...||.....:|   |...:.:::.:  .:|.|:  ....::.:|:.:|.:.
Worm   472 TYHTNFAKYGNPNGKGVSVPWEKYSLDNPGRYFKIDYPK--CEMADNFLDGRHKIIDEVNEHGIQ 534

  Fly   566 F 566
            :
Worm   535 Y 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	153/576 (27%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	63/162 (39%)
cest-35.2	NP_504398.1	COesterase	14..515	CDD:278561	153/564 (27%)
cest-35.2	NP_504398.1	Aes	<105..>239	CDD:223730	61/139 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I2624
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.760