DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and cest-27

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	587	Identity:	176/587 - (29%)
Similarity:	257/587 - (43%)	Gaps:	93/587 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLSHGGWLIGRHLTT-----------------HNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPW 80
            |...||:|...|..|                 .:|..:..|:|:||||||:..|||:.||....|
Worm    11 RFLMGGFLSKHHHLTAVHDATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKW 75

  Fly    81 EGERLAIKDAPICLQRDPFRRDMIL---EGSEDCLYLNVYTP--ERPRTNGSLPVMVWFHGGGWQ 140
            ......::..|...|.|......:.   :..|.||.|||:||  |........||||:.||||:.
Worm    76 TEPLDCVRFGPRSPQNDELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFA 140

  Fly   141 CGSGISSFYG----PDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANI 201
            ..|  ||.||    ...|...|:|:|:.|:|||.|||.:|....|.||.||.||...|.||:.||
Worm   141 VHS--SSNYGCASIARNLCTKDVVVVTINYRLGVLGFFTTGDEVCRGNLGLWDQTAALEWVQENI 203

  Fly   202 ASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKL 266
            .||.|||::||:||:|||||||....||..||||.:|.|..:|.....:|....: ..|..:.:.
Worm   204 QSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSE-QQAQLSREF 267

  Fly   267 AQIVGC-GNAGEWPEKLECLRKKPAEDI--------------VASLYDMFVWDFDPMIPFPPVVE 316
            |:.:|. |:..:..:.|:.:.::|...|              ..|||  ||
Worm   268 ARYLGWEGDDNDSEDLLQFIDQQPLYKIEMGINPKRGFKHSQAGSLY--FV-------------- 316

  Fly   317 PEHDGAFLTVAPRQAAKPHGLQLPLMVGATAEEGL--LKTAALLNLPQLLAEFKSQ-FEQVLPVV 378
            |..||.|.. .|....:....::.:|.|.|..|||  :...||...|:.:.:|..: |::
Worm   317 PNFDGDFFP-KPLNQLRKEAPKMQIMTGTTKYEGLFFIALGALSKNPEGIKKFMGRIFKE----- 375

  Fly   379 LNYDHHDDSVRQTITQRIESFYFKSGH--DYDKANHQNLTDLISDGWFVAGIDEYLRLRMS-QED 440
            .:|....|.|    .|.:..||||..|  |::|..|| :...|.|.....|......:... |.|
Worm   376 CDYGERADDV----LQMVYDFYFKGVHPKDHEKNMHQ-IVKFIGDYSINYGTYRLANIMTDLQHD 435

  Fly   441 VAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRELFVSAVPTQKDLELRELML 505
            |   |.|.||:..:|.| .:|: ....|.|:.|..|::|:  :|:.:.....|...|.::..:|.
Worm   436 V---YFYQFDYHNSAGF-GVFR-WLLPFLGSTHCTEMRYV--LGKGIISKFRPNDNDKKMLHVMT 493

  Fly   506 HLWVSFAKTGNPNPTNVSFHLPNWSP-ASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRD 569
            ..:.:|||.||||..|.  ....|.. .|::|  |......::||..:    .:..:.|.:.|..
Worm   494 TYFTNFAKYGNPNGENQ--ETGEWQKHDSAHP--FRHFKIDLDDSEMV----EDYQERRAELWDK 550

  Fly   570 LQ 571
            |:
Worm   551 LR 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	173/578 (30%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	67/143 (47%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	167/556 (30%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	71/171 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I1491
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.810