DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	180/590 - (30%)
Similarity:	270/590 - (45%)	Gaps:	76/590 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DAGLWSIRVILLCICIQWSDGRNS-QCLHVRLSHGGWLIGR--HL-TTHNGRHMRAFMGVPYAEP 64
            :|.|:.:.:||:.:   |  |::| :...:|.:|.|.:.|:  |: .|..|.|  .|:|:|:|:.
  Rat    11 NAVLFGLLLILIHV---W--GQDSPESSSIRTTHTGQVRGKLDHVRDTKAGVH--TFLGIPFAKA 68

  Fly    65 PLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRD-------MILEG---SEDCLYLNVYTP 119
            |:..|||.||....||.|.|.......:|||......:       |||..   ||||||||:|||
  Rat    69 PVGPLRFAPPEDPEPWSGVRDGTSHPAMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYTP 133

  Fly   120 ERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGN 184
            .......:|||||..|||....|.. |...|....::.|:|:|:..:|||.|||.||......||
  Rat   134 AHAHEGSNLPVMVCIHGGALVIGMA-SMCDGSLLAVNEDLVVVAIQYRLGVLGFFSTGDEHARGN 197

  Fly   185 NGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNP 249
            .|..||:..|.||:.|||.|||:||.||:||.||||.||:.|::|..|:||.|..|.:||....|
  Rat   198 WGYLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALLP 262

  Fly   250 WAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDI--VASLYDMFVWDFDPMIPFP 312
               ......:...:|.:|::.|| .|.:....:.|||.|...:|  :..::.|          .|
  Rat   263 ---DLISETSETVSTTVAKLSGC-EATDSETLVRCLRAKSGAEILVINKVFKM----------IP 313

  Fly   313 PVVEPEHDGAFLTVAPRQAAKPHGLQ-LPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLP 376
            .||    ||.||...|::........ :|.::|...:|.......::...|::.|..   .:.|.
  Rat   314 AVV----DGEFLPRHPKELLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELS---RENLQ 371

  Fly   377 VVLNYDHHDDSVRQTITQRIESFYFKS--GHDYDKANHQ-NLTDLISDGWFVAGIDEYLRLRMSQ 438
            .||.    |.:.:..:.........:.  |:..|....| ...:::.|..||.   ..|::...|
  Rat   372 AVLK----DTAAQMMLPPECGDLLMEEYMGNTDDPQTLQIQYAEMMGDFLFVI---PALQVAHFQ 429

  Fly   439 EDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRELFVSAVP-TQKDLELRE 502
            ...||.|.|.|.|  |.|:   ||..|.....|.||:|:.::|  |...:...|. |:::..|..
  Rat   430 RSHAPVYFYEFQH--APSY---FKNVRPPHVKADHADEVPFVF--GSFFWGIKVDFTEEEKLLSR 487

  Fly   503 LMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFW 567
            .|:..|.:||:.||||    |..||.| |...:..::.:|.|:.       .::..|...|:.||
  Rat   488 RMMKYWANFARHGNPN----SEGLPYW-PVLDHDEQYLQLDTQP-------AVDRALKARRLQFW 540

  Fly   568 RDLQP 572
            ....|
  Rat   541 TKTLP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	169/550 (31%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	61/137 (45%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	170/557 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910