DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and Ces3b

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	578	Identity:	179/578 - (30%)
Similarity:	251/578 - (43%)	Gaps:	139/578 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ------RDPF---RRDMILE 106
            |.:..|:|:|:|:.|:..|||..|:|..||||.|.|..:.|:|||      ...|   .:..|..
Mouse    58 RMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMCLQDVEKMINSRFGLNEKIKIFP 122

  Fly   107 GSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGIS------SFYGPDFLLDHDIVLVSAN 165
            .|||||.||:|:|.........|||||.|||....||..|      :.||       |:|:|:..
Mouse   123 ISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSQDGSALAAYG-------DVVVVTVQ 180

  Fly   166 FRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSE 230
            :|||..|||||.....|||.|..|.:..|.||:.|||.||||||.||:||.||||..|:...||.
Mouse   181 YRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSP 245

  Fly   231 KSRGLLHRGIAQSGTY-------FNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKK 288
            .|.||.||.|:|||..       ..||.:          |...|..|.||:|.. .|.::||.:|
Mouse   246 ISAGLFHRAISQSGIVTTIMMEDMKPWPE----------AQNFANSVACGSASP-AELVQCLLQK 299

  Fly   289 PAEDIVAS--------LYDMFVWDFDPMIPFPPVVEPEH---DGAFLTVAPRQAAKPHGLQLPLM 342
            ..:|::..        :.|.|         ||.  .||.   |..|.||             |.:
Mouse   300 EGKDLIKQKNVNISYIVNDSF---------FPQ--RPEKLLADQQFPTV-------------PYL 340

  Fly   343 VGATAEEG---LLKTAALLN-LPQL----LAEFKSQF-------EQVLPVVLNYDHHDDSVRQTI 392
            :|.|..|.   |||:..:|: |..|    |.|....|       .:::|.|::.
Mouse   341 LGVTNHEFGWLLLKSLNILDKLEHLSREDLLEISRPFLAIMEVPPEIMPTVIDE----------- 394

  Fly   393 TQRIESFYFKSGHDYDKANHQNLTDLISDGWFV---AGIDEYLRLRMSQEDVAPTYVYLFDHKGA 454
                   |..:|.| ..|......:|:.|..|:   ....:|||     :...|.::|.|.|. .
Mouse   395 -------YLDNGSD-QSATRYAFQELLGDISFIIPTLNFSKYLR-----DAGCPVFLYEFQHT-P 445

  Fly   455 ASFTEIFKGGRNEFYGACHAEELQYLFP---IGRELFVSAVP--TQKDLELRELMLHLWVSFAKT 514
            :||.: ||..   :..|.||.|..::|.   :..|..:.|.|  |:::.:|...|:..|..||:|
Mouse   446 SSFAK-FKPA---WVKADHASENSFVFGGPFLTDESSLLAFPEATEEEKQLSLTMMAQWSQFART 506

  Fly   515 GNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRDLQP 572
            ||||...    ||.| |..:...::..:|  :|....:     :|.:.|:.||.:..|
Mouse   507 GNPNGKG----LPPW-PQLNQLEQYLEIG--LESRTGV-----KLKKGRLQFWTETLP 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	176/571 (31%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	65/150 (43%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	176/571 (31%)
		Aes	75..>245	CDD:223730	77/176 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910