DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	568	Identity:	168/568 - (29%)
Similarity:	269/568 - (47%)	Gaps:	67/568 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GWLIGRHLTTHN-GRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ------ 95
            |.::|::::... .:.:..|:|||:|:|||..|||.||.|..||...:.|....|:|.|
Mouse    31 GKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCSQDAGWAK 95

  Fly    96 --RDPFRRD---MILEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLL 155
              .|.|..:   :.|:.||||||||:|:|.....:..||||||.||||...| |.|.:.|.....
Mouse    96 ILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIG-GASPYNGLALSA 159

  Fly   156 DHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGG 220
            ..::|:|:..:|||..|..||.....|||....|||..|.||:.|||:|||:|:|||:||||:||
Mouse   160 HENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGG 224

  Fly   221 ASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECL 285
            .||:..:||...:.|.||.|::||...|  .....|.:.|.... :|.:..|.:... ...::||
Mouse   225 ISVSVLVLSPLGKDLFHRAISESGVVIN--TNVGKKNIQAVNEI-IATLSQCNDTSS-AAMVQCL 285

  Fly   286 RKKPAEDI--VASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQ-AAKPHGLQLPLMVGATA 347
            |:|...::  ::.....:......||          ||..|..||.: .|:.....:|.:||...
Mouse   286 RQKTESELLEISGKLVQYNISLSTMI----------DGVVLPKAPEEILAEKSFNTVPYIVGFNK 340

  Fly   348 EE-GLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDKAN 411
            :| |.:....|.|   ||.|.|.. |:...::|...|.:.::.:::...:...|.: |.|.....
Mouse   341 QEFGWIIPMMLQN---LLPEGKMN-EETASLLLRRFHSELNISESMIPAVIEQYLR-GVDDPAKK 400

  Fly   412 HQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEE 476
            .:.:.|:..|.:|  ||...|..|..::....||:|.|.::  .||.   ...|.:.....|.:|
Mouse   401 SELILDMFGDIFF--GIPAVLLSRSLRDAGVSTYMYEFRYR--PSFV---SDKRPQTVEGDHGDE 458

  Fly   477 LQYLF--PIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEF 539
            :.::|  |:.:|     ..::::..|.::::..|.:||:.||||...    ||:| |.......:
Mouse   459 IFFVFGAPLLKE-----GASEEETNLSKMVMKFWANFARNGNPNGEG----LPHW-PEYDEQEGY 513

  Fly   540 ARLGTKMEDSASIFRLENELMQHRVDFWRDL----QPHL-PASHAHNE 582
            .::|...:.:.   ||:.|    .|.||.:|    .|.. |..|..::
Mouse   514 LQIGATTQQAQ---RLKAE----EVAFWTELLAKNPPETDPTEHTEHK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	162/546 (30%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	60/137 (44%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	158/533 (30%)
		Aes	<121..>234	CDD:223730	52/113 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810