Protein Alignment CG6414 and Ces1c

DIOPT Version :10

• Sequence 1: NP_570089.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_031980.2
• Gene: Ces1c / 13884
• MGIID: 95420
• Length: 554
• Species: Mus musculus
• Alignment Length: 568
• Identity: 168/568 - (29%)
• Similarity: 269/568 - (47%)
• Gaps: 67/568 - (11%)

  Fly    38 GWLIGRHLTTHN-GRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ------ 95
            |.::|::::... .:.:..|:|||:|:|||..|||.||.|..||...:.|....|:|.|
Mouse    31 GKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCSQDAGWAK 95

  Fly    96 --RDPFRRD---MILEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLL 155
              .|.|..:   :.|:.||||||||:|:|.....:..||||||.||||...| |.|.:.|.....
Mouse    96 ILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIG-GASPYNGLALSA 159

  Fly   156 DHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGG 220
            ..::|:|:..:|||..|..||.....|||....|||..|.||:.|||:|||:|:|||:||||:||
Mouse   160 HENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGG 224

  Fly   221 ASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECL 285
            .||:..:||...:.|.||.|::||...|  .....|.:.|.... :|.:..|.:... ...::||
Mouse   225 ISVSVLVLSPLGKDLFHRAISESGVVIN--TNVGKKNIQAVNEI-IATLSQCNDTSS-AAMVQCL 285

  Fly   286 RKKPAEDI--VASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQ-AAKPHGLQLPLMVGATA 347
            |:|...::  ::.....:......||          ||..|..||.: .|:.....:|.:||...
Mouse   286 RQKTESELLEISGKLVQYNISLSTMI----------DGVVLPKAPEEILAEKSFNTVPYIVGFNK 340

  Fly   348 EE-GLLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDKAN 411
            :| |.:....|.|   ||.|.|.. |:...::|...|.:.::.:::...:...|.: |.|.....
Mouse   341 QEFGWIIPMMLQN---LLPEGKMN-EETASLLLRRFHSELNISESMIPAVIEQYLR-GVDDPAKK 400

  Fly   412 HQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEE 476
            .:.:.|:..|.:|  ||...|..|..::....||:|.|.::  .||.   ...|.:.....|.:|
Mouse   401 SELILDMFGDIFF--GIPAVLLSRSLRDAGVSTYMYEFRYR--PSFV---SDKRPQTVEGDHGDE 458

  Fly   477 LQYLF--PIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEF 539
            :.::|  |:.:|     ..::::..|.::::..|.:||:.||||...    ||:| |.......:
Mouse   459 IFFVFGAPLLKE-----GASEEETNLSKMVMKFWANFARNGNPNGEG----LPHW-PEYDEQEGY 513

  Fly   540 ARLGTKMEDSASIFRLENELMQHRVDFWRDL----QPHL-PASHAHNE 582
            .::|...:.:.   ||:.|    .|.||.:|    .|.. |..|..::
Mouse   514 LQIGATTQQAQ---RLKAE----EVAFWTELLAKNPPETDPTEHTEHK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_570089.1	COesterase	28..567	CDD:395084	162/546 (30%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	158/533 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554		0/2 (0%)