Protein Alignment CG6414 and CES1

DIOPT Version :9

• Sequence 1: NP_001303565.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 188/610 - (30%)
• Similarity: 286/610 - (46%)
• Gaps: 75/610 - (12%)

  Fly     7 LWSIRVIL--LCICIQWSDGRNSQCLHVRLSHGGWLIGRHLTTHN-GRHMRAFMGVPYAEPPLDD 68
            :|....||  |.....|: |..|....|...||. ::|:.::... .:.:..|:|:|:|:|||..
Human     1 MWLRAFILATLSASAAWA-GHPSSPPVVDTVHGK-VLGKFVSLEGFAQPVAIFLGIPFAKPPLGP 63

  Fly    69 LRFRPPVPKAPWEGERLAIKDAPICLQRDP-----------FRRDMI-LEGSEDCLYLNVYTPER 121
            |||.||.|..||...:.|....|:|.| ||           .|::.| |:.||||||||:|||..
Human    64 LRFTPPQPAEPWSFVKNATSYPPMCTQ-DPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPAD 127

  Fly   122 PRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNG 186
            ......||||||.||||...|:. |::.|.......::|:|:..:|||..||.||......||.|
Human   128 LTKKNRLPVMVWIHGGGLMVGAA-STYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWG 191

  Fly   187 LKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA 251
            ..||:..|.||:.|||||||:|.|||:|||||||.||:..:||..::.|.||.|::||....  :
Human   192 HLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALT--S 254

  Fly   252 QPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDF----DPMIPFP 312
            ....||.....|.::|...||..... ...:.|||:|..|:::.:...|.....    ||. ...
Human   255 VLVKKGDVKPLAEQIAITAGCKTTTS-AVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPR-ESQ 317

  Fly   313 PVVEPEHDGAFLTVAPRQ-AAKPHGLQLPLMVGATAEE-GLLKTAALLNLPQLLAEFKSQFEQVL 375
            |::....||..|...|.: .|:.:...:|.|||...:| |.|....|::.|  |:|  .|.:|..
Human   318 PLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYP--LSE--GQLDQKT 378

  Fly   376 PVVLNYDHHD--DSVRQTITQRIESFYFKSGHDYDKANHQNL-TDLISDGWFVAGIDEYLRLRMS 437
            .:.|.:..:.  ...::.|.:..|.:.  .|.| |....::| .|||:|..|  |:...:..|..
Human   379 AMSLLWKSYPLVCIAKELIPEATEKYL--GGTD-DTVKKKDLFLDLIADVMF--GVPSVIVARNH 438

  Fly   438 QEDVAPTYVYLFDHKGAASFTEIFK-----GGRNEFYGACHAEELQYLFPIGRELFVSAVPTQKD 497
            ::..||||:|.|.::  .||:...|     |.        |.:|   ||.:....|:....::::
Human   439 RDAGAPTYMYEFQYR--PSFSSDMKPKTVIGD--------HGDE---LFSVFGAPFLKEGASEEE 490

  Fly   498 LELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENELMQH 562
            :.|.::::..|.:||:.||||...    ||:| |..:....:.::|...:.:       .:|...
Human   491 IRLSKMVMKFWANFARNGNPNGEG----LPHW-PEYNQKEGYLQIGANTQAA-------QKLKDK 543

  Fly   563 RVDFWRDL----QPHLPASHAHNEL 583
            .|.||.:|    ....|....|.||
Human   544 EVAFWTNLFAKKAVEKPPQTEHIEL 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	173/557 (31%)
		Aes	<116..>254	CDD:223730	61/137 (45%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	174/563 (31%)
		Aes	<122..>240	CDD:223730	55/118 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6088
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760