DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and tg

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001316486.1	Gene:	tg / 100492021	XenbaseID:	XB-GENE-6073495	Length:	2780	Species:	Xenopus tropicalis

Alignment Length:	589	Identity:	152/589 - (25%)
Similarity:	242/589 - (41%)	Gaps:	118/589 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GWLIGRH---LTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPF 99
            |.|:|:.   :...|.:::..|:|:|||.||:...||.||.| ..|.||..|......|||....
Frog  2223 GTLLGKSEAVVIGSNIKNVVQFLGIPYAAPPVGVYRFSPPQP-VNWTGEWNATYSRASCLQPGDG 2286

  Fly   100 RRDMILEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLD-HDIVLVS 163
            :......| ||||||||:.|:...||.:  |:::||...........:|....:|.. .:||:|:
Frog  2287 KAQYSSVG-EDCLYLNVFVPQHAGTNAA--VLLYFHNSPSDYSEKGQTFIDGSYLAAIGNIVVVT 2348

  Fly   164 ANFRLGPLGFLSTETLDCP-GNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHM 227
            |.:|:|..||||......| ||.||.||:..|.||:.|||.|||||..:::..:.||....:.|.
Frog  2349 AGYRVGVFGFLSNTGETAPSGNWGLLDQVAALKWVQENIAYFGGDPTLISIAADRAGADISSIHT 2413

  Fly   228 LSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAED 292
            :..:.: |..|.:...|:.|:|....:.|. |..:...||..|.|.::.:  :.|.|||...|..
Frog  2414 IVPEGK-LFRRALLMGGSAFSPMMVTSEKR-AKEQVEFLAAEVECSSSNK--DLLTCLRGVDAGA 2474

  Fly   293 IVASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQAAKPHGLQ-LPLMVGATAEEGLLKTAA 356
            :.|:...:.. ...|...:.|:|    |..::...|.:..|....| :.|::|::..:||:..|.
Frog  2475 LNAAQTKLLA-QRGPFQTWGPIV----DKLYVKETPSRMLKQKKFQKIDLLIGSSELDGLISRAK 2534

  Fly   357 LLNLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQ-RIESFYFKSGHDYDKANHQNLTDLIS 420
            .:          .:||:                   || |::...|          :|.|.:.:
Frog  2535 AI----------KRFEE-------------------TQGRVDKTAF----------YQALQNSL- 2559

  Fly   421 DGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKG--AASFTEIFKGGRNEFYGAC-------H-AE 475
                 .|::....|   ||  |..:.|..:|..  ...|::..:....:.:.||       | ||
Frog  2560 -----GGVEANSLL---QE--AAVWFYSLEHSSDDYTGFSKALEKATRDHFIACPVIKMAKHWAE 2614

  Fly   476 ELQ---YLFPIGRELFVSA----VPT------------------QKDLELRELMLHLWVS-FAKT 514
            ..:   ||:.:...|..|:    :|.                  ..:.::..|.:..:|| |.:|
Frog  2615 NSKGNIYLYHVPDTLSQSSSGLDLPEDVIRAFGLPFHTNYKNQFSSEEQILSLKIMQYVSNFVRT 2679

  Fly   515 GNPN-P----TNVSFHLPNWSPASSYPVEFARL-GTKMEDSASIFRLENELMQHRVDFWRDLQPH 573
            |||| |    ..:|..||.|      |:..|.. ||..::.:|.......|......||.|..|.
Frog  2680 GNPNFPYKFLRRISKELPAW------PMYLAHSNGTNYKEFSSSLTNNQGLKNSECSFWNDYIPT 2738

  Fly   574 LPAS 577
            |..|
Frog  2739 LKVS 2742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	146/577 (25%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	45/139 (32%)
tg	NP_001316486.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910