DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and Ces1f

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	189/599 - (31%)
Similarity:	276/599 - (46%)	Gaps:	121/599 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GWLIGRHLTTHN-GRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ---RDP 98
            |.::|::::... .:.:..|:|||:|:|||..|||.||.|..||...:......|:|.|   :..
  Rat    31 GKVLGKYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDAAKGQ 95

  Fly    99 FRRDMI--------LEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLL 155
            ...|::        ||.||||||||:|||.....|..||||||.||||...| |.|::.|.....
  Rat    96 RMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVWIHGGGMTLG-GASTYDGRVLSA 159

  Fly   156 DHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGG 220
            ..::|:|:..:|||..||.||......||.|..||:..||||:.|||:|||||.|||:|||||||
  Rat   160 YENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGG 224

  Fly   221 ASVTYHMLSEKSRGLLHRGIAQSGTYFNPW-----AQPAHKGVA--AG-RATKLAQIVGCGNAGE 277
            .||:..:||..::.|.||.|::||..|.|.     .:||.|.:|  || ..|..|.||.|.....
  Rat   225 FSVSVLVLSPLTKNLFHRAISESGVVFLPGLLTKDVRPAAKQIADMAGCETTTSAIIVHCLRQKT 289

  Fly   278 WPEKLECLRK------------KPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQ 330
            ..|.||.::|            |.:...::::.|..|...||.       |...:..|.||
  Rat   290 EEELLEIMKKMNLIKLSSQRDNKESYHFLSTVVDNVVLPKDPK-------EILAEKNFNTV---- 343

  Fly   331 AAKPH---------GLQLPLMVG-ATAEEGLLKTAALLNLPQLLAEFKSQF---EQVLPVVLNYD 382
               |:         |..||.|:| ..|:..|.|..|:    .||.:|.|.:   |.::||.:.
  Rat   344 ---PYIVGINKQECGWLLPTMMGFVPADVELDKKMAI----TLLEKFASLYGIPEDIIPVAIE-- 399

  Fly   383 HHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVY 447
                             .::.|.|........:...|.|..|  .|...:..|..::..||||:|
  Rat   400 -----------------KYRKGSDDSIKIRDGILAFIGDVSF--SIPSVMVSRDHRDAGAPTYMY 445

  Fly   448 LFDHKGAASFTEIFKGGRNEFYGACHAEELQYLF--PIGRELFVSAVPTQKDLELRELMLHLWVS 510
            .:.:..:.|..:     |.:.....||::|..:|  ||.|:     ..::::::|.::::..|.:
  Rat   446 EYQYYPSFSSPQ-----RPKHVVGDHADDLYSVFGAPILRD-----GASEEEIKLSKMVMKFWAN 500

  Fly   511 FAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRDL----- 570
            ||:.||||...    ||:| |......|:.::|...:.|.   ||:.|    .|.||..|
  Rat   501 FARNGNPNGRG----LPHW-PQYDQKEEYLQIGATTQQSQ---RLKAE----EVAFWTQLLAKRQ 553

  Fly   571 -QPHLPASHAHNEL 583
             |||      ||||
  Rat   554 PQPH------HNEL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	179/575 (31%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	66/142 (46%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	179/575 (31%)
		Aes	<121..>234	CDD:223730	57/113 (50%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm44890
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810