Protein Alignment lva and CROCC

DIOPT Version :9

• Sequence 1: NP_001284849.1
• Gene: lva / 31350
• FlyBaseID: FBgn0029688
• Length: 2779
• Species: Drosophila melanogaster
• Sequence 2: XP_011540770.2
• Gene: CROCC / 9696
• HGNCID: 21299
• Length: 2151
• Species: Homo sapiens
• Alignment Length: 2604
• Identity: 599/2604 - (23%)
• Similarity: 1016/2604 - (39%)
• Gaps: 780/2604 - (29%)

  Fly   137 TSGSEKLLMLTQRTEQNRA-----LLEQRKRDLAKSLLSVKSNIGHQTTAELGSSMTDL------ 190
            |.||:    :|....||.|     .|....|.|..|:|..:..:|.:..|: .:.:|.|
Human   128 TRGSD----MTSWDPQNPAGLWGRTLGMEPRTLESSVLCQEKGLGARDLAQ-DAQITSLPALIRE 187

  Fly   191 ---RHAASVSNP---PVSRHRSALDLEAQGQEAVDE-SRVKLLRSRMKLTELKQGRQEQELNELR 248
               |:.:...:|   |.:...|.|.|:.:.|....| |||:.|        |.|.|.|      |
Human   188 IVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDL--------LAQSRAE------R 238

  Fly   249 TELA-KRAKLIERLE----LSGAELQ----RTLTQRNEEL-EQLRVVQA----------EEDSLK 293
            .||| |...:.||||    |...||:    |.|.:::.|| .||:..||          |....:
Human   239 DELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQ 303

  Fly   294 VQENSRLQGEVLVLRERLAELENVNDLLETTRCELQEELTTARERQRNLE-----LEQEQEKASR 353
            .|...||||::|..::|.:|||  ..|||.:. ||:::.....|..::||     ||:||::::
Human   304 AQLVQRLQGKILQYKKRCSELE--QQLLERSG-ELEQQRLRDTEHSQDLESALIRLEEEQQRSA- 364

  Fly   354 SPQSEAAHTDAQVSAELAKQLQELTNQLADLQATNEELRQQVAAQAKLQVTDEIVSQRLEELEAT 418
                    :.|||:|.|.:||.:..:.   .||.:|::|         :||::....| :|||..
Human   365 --------SLAQVNAMLREQLDQAGSA---NQALSEDIR---------KVTNDWTRCR-KELEHR 408

  Fly   419 IAAQLLELQEQKSAMAAQNEELAEKTTELNVLNVNLRLLEEKLAQSSRSKPLFLEDHSEDSAASK 483
            .||...|.:...:..:.::..|.....::    |..|.|..::       .:|.|
Human   409 EAAWRREEESFNAYFSNEHSRLLLLWRQV----VGFRRLVSEV-------KMFTE---------- 452

  Fly   484 QMQEDLQQLKLKLDETNKA--------NIKLKLKCKQAEKKLQK---FQSQDGQQQLASLLADNE 537
               .||.||..:|..|::|        :..|:|...:||..|:|   .|:|..:|....:|.:.:
Human   453 ---RDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD 514

  Fly   538 ELQQRIAVLEDEKGQWQLANMQEDDRQPEQSTESNNPLQLETIRLLEEQKLELQQALEALLSSSS 602
            ..||:               ||.|..:.:.|..... |.| .::.||:|.||..|..:.|.....
Human   515 LAQQQ---------------MQSDLDKADLSARVTE-LGL-AVKRLEKQNLEKDQVNKDLTEKLE 562

  Fly   603 SAESIEIVERHHLECLGQRRPASEGDAQEQKQVHPPGPSHVSELTQTEQTEEEDSSGETLSQLRE 667
            :.||:.:.|:..||                                   ||:.:...:||..|
Human   563 ALESLRLQEQAALE-----------------------------------TEDGEGLQQTLRDL-- 590

  Fly   668 RLELFTQERGEVLDKLEQLSAENLQLQARLEESSSSLQLLQREREKDLISSTSTSSNLSQELSSM 732
                                     .||.|.:|.|.:||...||       |:.:||.|....|.
Human   591 -------------------------AQAVLSDSESGVQLSGSER-------TADASNGSLRGLSG 623

  Fly   733 QRSSEVVATLDAGEG-----GPVLFEKCEKSLSKLNSELEAYR-KANDRQAKFNVSKKLAKEAKN 791
            ||:.........|.|     ||........:|:.::|.|...: :..|.:.::..|:
Human   624 QRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQ-------- 680

  Fly   792 CHTQLSELLHKVKEASTAVETVTVVETVVAVTAPNGKALAEYEQLNAQNAELKAVISRLRQELDE 856
                  :||..::                       |.|::.|   ::...|:..:.|||.:.|.
Human   681 ------DLLGTLR-----------------------KQLSDSE---SERRALEEQLQRLRDKTDG 713

  Fly   857 LRESYPETEAPLAIVGSDSQREDEILQLQSQLED------ARSLQAEQRQQIEEQVDQIKELRQT 915
            ..:::           .|:|||.:.|:..::|..      |.|||..|:        |.:||||
Human   714 AMQAH-----------EDAQREVQRLRSANELLSREKSNLAHSLQVAQQ--------QAEELRQ- 758

  Fly   916 EAEQLQLVARQSAEITQLQLQSEQFDQLLNSKEMSHEKQLEQQTRIRRELE---ARAESLEGELS 977
            |.|:|| .|::.....:.:|:.||            |..::...|:|||||   .:.|.|||:.|
Human   759 EREKLQ-AAQEELRRQRDRLEEEQ------------EDAVQDGARVRRELERSHRQLEQLEGKRS 810

  Fly   978 ILQTLVAEQKQQLIESVSESEHALNLKMLELQSAQEELRELRAKEDPDQLREALRVSKSLVAQQV 1042
            :|...:.|.::.|      |...|...||:.:.|  |:.|...|.:..::...|.::| |.|::.
Human   811 VLAKELVEVREAL------SRATLQRDMLQAEKA--EVAEALTKAEAGRVELELSMTK-LRAEEA 866

  Fly  1043 RELTSSQETVDALNQQIQEYQGLEHAHKEEQFKNR---ELREKLKKYALNLKKR-TQDNADLEQK 1103
             .|..|...:.|||:.:.:         ::...||   :|.|  :|.||..::| .:..|.:.::
Human   867 -SLQDSLSKLSALNESLAQ---------DKLDLNRLVAQLEE--EKSALQGRQRQAEQEATVARE 919

  Fly  1104 VQELTSQLQEQQELVKQ------------KEEVEREPIVDNHRVEQLQQQVSKLNEDLKAKIHLN 1156
            .||...:|:.:||:.:|            :|.:|::.....|...|||:|:::|:..|..:   .
Human   920 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGR---E 981

  Fly  1157 LENRDALRQLKQQIQEQEQLIQERDAELQDANLVSKE---LRRERQEADQEVFQLGQENSRLREE 1218
            .|...|.|:.::|::..|:..:|::|       ::||   |..:...|::|...|.:|.:|||.|
Human   982 QELEQARREAQRQVEALERAAREKEA-------LAKEHAGLAVQLVAAEREGRTLSEEATRLRLE 1039

  Fly  1219 ISKLQEEIHNLGQRVNEEPTAVEDLRRQLEAKSKKFEKSK-----ELIKLRNATI-----QSLQR 1273
            ...|:..:.    .|..:...:|..|.||||:.:....:|     ||..||...|     .||.:
Human  1040 KEALEGSLF----EVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDK 1100

  Fly  1274 EL--QQLQQDQDSEVEHVRNARAAHEQ--LRLEKDAEITALRQEILKLERSRAAGEGDDTITKTS 1334
            ||  |:|.|.:......:|..|||||:  .||:::.| .|.|:    ||..||.
Human  1101 ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKE-AAWRE----LEAERAQ----------- 1149

  Fly  1335 HQLLESQSQ-QQAESLQVAERELQQLRVQLTAAQEQH---ALLAQQYASDKANFEMTIARLETLH 1395
               |:||.| :|.|.|...|.|.::|..::.|.|::.   .|||:   |:|             .
Human  1150 ---LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE---SEK-------------Q 1195

  Fly  1396 EGIQAKLQEDASYIESLEAQNTELQARSAALEEQAASQANQQAASQDKVQILEQQLKEQREQEEQ 1460
            :.:..|..|..:..|.|......|...|..:|.|.....::|...:..|..|..:|::.|.|.|:
Human  1196 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1260

  Fly  1461 ----KRQQDQQLQERFYELGQREQAQSRQLELLTSEAEESRQQLA-------GLRTEYESLLAKH 1514
                ..|:.::|||:..:||::..:..|       ||||.|.||.       |||.|   ||...
Human  1261 AAAAHAQEVRRLQEQARDLGKQRDSCLR-------EAEELRTQLRLLEDARDGLRRE---LLEAQ 1315

  Fly  1515 SQLTATAQAEREQMSSHSQEELAELRQQL--DVKEADLHRQRQVYDAKLAAKATELDELECDL-- 1575
            .:|..:.:....|     ::|..|||:.|  ..||.:..| |...:.:.|.|..|.:.:...|
Human  1316 RKLRESQEGREVQ-----RQEAGELRRSLGEGAKEREALR-RSNEELRSAVKKAESERISLKLAN 1374

  Fly  1576 -------------NSHVERAAAETRELCQQLERSQELVAQRTEELQRLNEEFQEVERERSTLSRE 1627
                         .:.|.:.|.|.|...|::|||: |.|:|  |||.|..:.:.::.|.:.|.||
Human  1375 EDKEQKLALLEEARTAVGKEAGELRTGLQEVERSR-LEARR--ELQELRRQMKMLDSENTRLGRE 1436

  Fly  1628 VTLLR----LQHDSAEQDVLELQELRMQAMQDKTEMDNLRTQIDALCANHSQELQALQQRIAELD 1688
            :..|:    |...:.::...|...||.:.::.:..::.:|           ||||..|:::.|.:
Human  1437 LAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMR-----------QELQVAQRKLQEQE 1490

  Fly  1689 TLGQNQTDDQVYIETENKRLAEQLSELQAQLARQQHQQQQQQHHHPAVQSQQHPPPASLFFGGDA 1753
              |:        ..|..:||...|.|.:..      ::||..|
Human  1491 --GE--------FRTRERRLLGSLEEARGT------EKQQLDH---------------------- 1517

  Fly  1754 LAAPSPFDEIAQPLRVSSLAASAPPPISPPPTIEDLQRNVSDLEKHAQDLETKLLARNQNLAEQE 1818
                      |:.|.:...||.|        ...:|...:|..|..||.||.:|
Human  1518 ----------ARGLELKLEAARA--------EAAELGLRLSAAEGRAQGLEAEL----------- 1553

  Fly  1819 ERRLQLEQRLSEVERLLSERTQQLADIQTANEERDRLAALEKLIQPAAAPTLDMFFGGQAEETVP 1883
             .|:::::|.:|.         ||..:::|..   |...|.:...||..|..    |..|.:...
Human  1554 -ARVEVQRRAAEA---------QLGGLRSALR---RGLGLGRAPSPAPRPVP----GSPARDAPA 1601

  Fly  1884 DAVSHHLDLGLPQTEPVVEPLIQPKKAYLCQPKQEIQEQTAQTIDWGVDEDPWASAANEAPQTDV 1948
            :....  .|..|.|   :|          |.|..:             ...|..:.:..:|..|.
Human  1602 EGSGE--GLNSPST---LE----------CSPGSQ-------------PPSPGPATSPASPDLDP 1638

  Fly  1949 EHLHTRIAQLELQLSNAEQQKTELQTKAAKLMKRLKEYKTKATTTATPTVTVDNDLDSTIIEELK 2013
            |.:...:.:...:|.:|::::.||:|:.:.|.::|.|.:.:
Human  1639 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAE------------------------ 1679

  Fly  2014 HQLQLQESRLSKAEEISQQHALEKEKLAKRIDVLTAGNDRMAEMKERQDMDVQMYQARIRELQEK 2078
                 ::|..|:|.:: |:...|.|:..:.:|...:|        .:.::.:|....| |..:|:
Human  1680 -----RDSATSRARQL-QKAVAESEEARRSVDGRLSG--------VQAELALQEESVR-RSERER 1729

  Fly  2079 LSQLDQWGEPAATVSSSLDGDEAARIESLQQEIQQLRQQVSELEDERTRDQAELGALRQSSQGYD 2143
            .:.|||    .||:..||...| :.:.:.|::|.:::...::||.::          |:..:..|
Human  1730 RATLDQ----VATLERSLQATE-SELRASQEKISKMKANETKLEGDK----------RRLKEVLD 1779

  Fly  2144 EAEDNQ-KLELQQLRQQESELEALRTRDQSELEALRQSCQGH---------DETVRIATLQQDNQ 2198
            .:|... |||||: |..|.||:..|. ..|:.||..|:.|..         |..|:..||
Human  1780 ASESRTVKLELQR-RSLEGELQRSRL-GLSDREAQAQALQDRVDSLQRQVADSEVKAGTL----- 1837

  Fly  2199 QLELQQLRQAIIELE----TLRARDQTELEALRQSSQG-------------------HD------ 2234
            ||.:::|..|:.::|    .||.:.:...|||.|||..                   ||
Human  1838 QLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1902

  Fly  2235 --EAARIAIEQRDNQQLEL----QQLRQQLIELEALRARDQAELEALRQSCQGQQLSVDMASRND 2293
              :|||.|:.:...|...|    |.||.::.:||..|...:.:|:.||
Human  1903 RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR----------------- 1950

  Fly  2294 EQMAQLQEKESEIVHLKQRIEELMREDQTEKLVFEILTKNQELQLLRMQVKQLEEDKEDQQVSAA 2358
            |.:.|.||.|:..::..|::::..|..|            :.|..|:..:.|||.:|.:.:.||.
Human  1951 EVLRQRQEGEAAALNTVQKLQDERRLLQ------------ERLGSLQRALAQLEAEKREVERSAL 2003

  Fly  2359 PPKDD----GETVEKLKSLCQQLQQEKSDMEEELRVLNNHVLSSLELEDRMKQTLLQLDTKNIEI 2419
            ..:.|    ..|::|::             .|:||...:.|..|.| :.|:.:||...:   :|:
Human  2004 RLEKDRVALRRTLDKVE-------------REKLRSHEDTVRLSAE-KGRLDRTLTGAE---LEL 2051

  Fly  2420 TELRRSLEILQSQNLGQNSAAEQIPDLSAINQQWEQLVEQKCGEVASIWQEHLSQREAAFKAQLE 2484
            .|.:|.::.|::|                               |..:.|.|       ..||||
Human  2052 AEAQRQIQQLEAQ-------------------------------VVVLEQSH-------SPAQLE 2078

  Fly  2485 EVTQQQQRELPQSQQ-----STQGEATSDIMQKM-QKALETQEMEIVTLKEQLAIRSAEYARLAA 2543
            ...||||.||.|..:     ..|.|.|.:..::. ::.:...|.::.|||.||   ..|..|.:|
Human  2079 VDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL---QQELRRSSA 2140

  Fly  2544 QYDP 2547
            .:.|
Human  2141 PFSP 2144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lva	NP_001284849.1	SMC_prok_B	327..1151	CDD:274008	192/870 (22%)
		SMC_prok_B	952..1721	CDD:274008	214/840 (25%)
		SMC_prok_B	1475..>2183	CDD:274008	156/736 (21%)
CROCC	XP_011540770.2	SMC_N	<214..>764	CDD:330553	174/758 (23%)
		Rootletin	290..467	CDD:317452	55/225 (24%)
		SMC_N	747..1560	CDD:330553	246/1002 (25%)
		SMC_N	<1269..2000	CDD:330553	208/962 (22%)
		SMC_N	1900..>2135	CDD:330553	71/321 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000