DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lva and TNIP2

DIOPT Version :9

Sequence 1:	NP_001284849.1	Gene:	lva / 31350	FlyBaseID:	FBgn0029688	Length:	2779	Species:	Drosophila melanogaster
Sequence 2:	NP_077285.3	Gene:	TNIP2 / 79155	HGNCID:	19118	Length:	429	Species:	Homo sapiens

Alignment Length:	435	Identity:	100/435 - (22%)
Similarity:	173/435 - (39%)	Gaps:	122/435 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1163 LRQLKQQIQEQEQLIQERDAELQDANLVSKELRRERQEADQEVFQLGQENSRLREEISKLQEEIH 1227
            ||:|:.|:..::.||         |.|.::....|...|...|..|.::.:|.||::
Human    31 LRRLQDQLAARDALI---------ARLRARLAALEGDAAPSLVDALLEQVARFREQL-------- 78

  Fly  1228 NLGQRVNEEPTAVEDLRRQLEAKSKKFEKSKELIKLRNATIQSLQRELQQL----QQDQDSEVEH 1288
                |..|...|...:|:::|..:::.|:.              :||:|||    |.:::.||..
Human    79 ----RRQEGGAAEAQMRQEIERLTERLEEK--------------EREMQQLLSQPQHEREKEVVL 125

  Fly  1289 VRNARAAHEQLRLEKDAEITALRQEILKLERSRAAGEGDDTITKTSH---QLLESQSQQQAESLQ 1350
            :|.:.|..|:.|...|....:|..|..:|.|         |:|.|:|   .|.:...::|.....
Human   126 LRRSMAEGERARAASDVLCRSLANETHQLRR---------TLTATAHMCQHLAKCLDERQHAQRN 181

  Fly  1351 VAERELQQLRVQLTAAQEQHALLAQQYASDKANFEMTIARLETLHEGIQAKLQEDASYIESLEAQ 1415
            |.||         :..|.:|        :|.             |..:|       |.||.|:.:
Human   182 VGER---------SPDQSEH--------TDG-------------HTSVQ-------SVIEKLQEE 209

  Fly  1416 NTELQARSAALEEQAASQANQQAASQDKVQILEQQLKEQREQEEQKRQQDQQLQERFYELGQREQ 1480
            |..|:.:...:|:..|......|:..:.|:.|..||:..:...|.             ||.::|.
Human   210 NRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEP-------------ELMRKEI 261

  Fly  1481 AQ-SRQLELLTSEAEESRQQLAGLRTEYESLLAK----HSQLTA------TAQAEREQMSSHSQ- 1533
            :: :||||...::..|.:|:||..||..::.|.:    ..|:.|      :.:|:||:..|..|
Human   262 SRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326

  Fly  1534 --EELAELRQQL----DVKEADLHRQRQVYDAKLAAKATELDELE 1572
              |::|.|..|:    |.:|.|..|   ::.....||....|.||
Human   327 LEEKVASLLHQVSWRQDSREPDAGR---IHAGSKTAKYLAADALE 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lva	NP_001284849.1	SMC_prok_B	327..1151	CDD:274008
		SMC_prok_B	952..1721	CDD:274008	100/435 (23%)
		SMC_prok_B	1475..>2183	CDD:274008	33/116 (28%)
TNIP2	NP_077285.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..199		7/51 (14%)
		EABR	214..246	CDD:288991	6/31 (19%)
		UBAN	258..339	CDD:301588	23/80 (29%)
		Ubiquitin-binding domain (UBD)	289..347		13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8279
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950