Protein Alignment lva and cenpe

DIOPT Version :9

• Sequence 1: NP_001284849.1
• Gene: lva / 31350
• FlyBaseID: FBgn0029688
• Length: 2779
• Species: Drosophila melanogaster
• Sequence 2: NP_001314688.1
• Gene: cenpe / 767754
• ZFINID: ZDB-GENE-060929-860
• Length: 2690
• Species: Danio rerio
• Alignment Length: 2988
• Identity: 622/2988 - (20%)
• Similarity: 1196/2988 - (40%)
• Gaps: 819/2988 - (27%)

  Fly    76 KERALRKSQDERHKSSMSDSMESLKTLGQKLTVLKTRSGDSSTPLVSPTKDSDPGDVSLLQTSGS 140
            ||..||.|..|.:..:::|    |.....|...|:.|.|:.....|:...:.       |.||..
Zfish   128 KEFLLRVSYMEIYNETVTD----LLCDSWKRKPLEIREGNYKNVYVADLTEE-------LVTSPE 181

  Fly   141 EKLLMLTQ--------RTEQN----------RALLEQRKRD-----------LAKSLLSVKSNIG 176
            :.|..:|:        :|:.|          |.:||.|:|.           :..|.|::....|
Zfish   182 QALSWITKGEKNRHYGKTKMNQRSSRSHTIFRMILESRERSDPTAGESADGAIIVSHLNLVDLAG 246

  Fly   177 HQTTAELGSSMTDLRHAASVSNPPVSRHRSALDLEAQGQEAVDESRVKLLRSR-MKLTELKQGRQ 240
            .:..::.|:.....:...::       :||...|....::..|||:...|..| .|||.:
Zfish   247 AERASQTGAEGARFKEGCNI-------NRSLFTLGQVIKKLSDESQKGFLNYRDSKLTRI----- 299

  Fly   241 EQELNELRTELAKRAKLIERLELSGAELQRTLT----------QRNEELEQLRVVQAEEDSLKVQ 295
                  |:..|...||.:....::.|.:..|::          .:|:.    .|.:..::...::
Zfish   300 ------LQNSLGGNAKTVIICTITPATVDETVSTLQFASAAKRMKNDP----HVTEVSDEGALLR 354

  Fly   296 ENSRLQGEVLVLRERLAELENVNDLLETTRCELQEELTTARERQRNLELEQEQEKASRSPQSEAA 360
               |.:.|::.|:.||.|:.:|..             |||.||:...:|.||:::..|..:
Zfish   355 ---RYRNEIVDLKRRLQEVSSVTQ-------------TTATERESLCQLLQEKDQLQREQE---- 399

  Fly   361 HTDAQVSAELAKQLQELTNQLADLQATNEELRQQVAAQAKLQVTDEIVSQRLEELEATIAAQLLE 425
                    :..|.|.:|....:::....:..:::|....||..:..::::.|...:.:.|...|:
Zfish   400 --------DRIKNLTKLLVTSSNIALIPKVPKRRVTWGGKLLRSAHLLNEDLCSTDMSFAEPYLK 456

  Fly   426 LQEQKSAMAAQNEELAE-----KTTELNVLNVNLRLLEEKLAQSSRSKPLFLEDHSEDSAASKQM 485
            .:....::|...|::.|     ..|.:...|:::.:....:..||..      .|..||..:.::
Zfish   457 KRRADCSLADVGEDMDEFDSRFDFTAMEEPNMDMEMSSITVRSSSEG------SHFLDSPRASEL 515

  Fly   486 QEDLQQLKLKLD---------ETNKANIKLKLKCKQAEKKLQKFQSQDGQQQLASLLADNEELQQ 541
            .:.:..|:.:|:         |...|.:::||...|...:.|...|.:.:..::.|....|:||:
Zfish   516 MQKVSSLESQLEAETQSKQIAEEMNAELQMKLSHLQNMLEAQSAPSHEEKNTISELEKQMEDLQR 580

  Fly   542 RIAVLEDEKGQWQLANMQEDDRQPEQSTESNNPLQLETIRLLEEQKLELQQALEALLSSSSSAES 606
            |   ||.|        :||.....|:|..            ||.:..||::..|.||.|.::.|.
Zfish   581 R---LETE--------VQERQTAEEKSIS------------LELKVAELEKPSEELLHSQNTCER 622

  Fly   607 I--EIVERHHLECLGQRRPASEGDA--QEQKQVHPPGPSHVSELTQTEQTE----EEDS---SGE 660
            :  ::.|...| |   ...:.|.||  .|:..:     .|..::| ||:.|    |:||   ..:
Zfish   623 VKKDLEEAIQL-C---ETVSFEKDAVIAERDMI-----KHSLDMT-TEELESLKAEKDSLQKEKD 677

  Fly   661 TLSQLRERLELFTQER--GEVLDKLE---------QLSAENLQLQARLEESSSSLQLL------- 707
            .|.:.::.|:...:||  .:..:|||         :|.|||.:|:..|::|...:|.|
Zfish   678 ALQKDKDALQKDMEERRDADEFEKLEEESKRDYERELEAENSRLEKNLKQSEDMIQKLKADLALM 742

  Fly   708 --QREREKDLISSTS--TSSNLSQELSSMQRSSEVVATLDAGEGGPVLFEKCEKSLSKLNSELEA 768
              :.:::.||.:...  :..::.||::.::||.:...||..         :.:|..:.|.||..:
Zfish   743 SSELQKKTDLTTELQGFSGKDIVQEVTRLRRSLDDAETLSL---------ETKKEWAFLRSENIS 798

  Fly   769 YRKANDRQAKFNVS-KKLAKEAKNCHTQLSELLHKVKEASTAV--ETVTVVETVVAVTA-PNGKA 829
            .:   :|....... .|:..|.|....:|.:...:.|:..|.:  |.:...:....:|| .:||.
Zfish   799 LK---ERDVTLTTDYGKMEAEVKMLQDRLEQEKSRFKKMQTDLQKELMGAFDENTKLTALMDGKV 860

  Fly   830 LAEYEQLNAQNAELKAVISRLRQELDELRESYPETEAPLAIVGSDSQREDEIL-QLQSQLEDARS 893
            ....    ..|..|:..:..||:|||::||.....::.::.:.:...:.||:| |:....|:.||
Zfish   861 PKNL----TDNVVLEKTVCDLRKELDQIREREQSLQSKVSELETLPAKVDELLGQVCVVSEELRS 921

  Fly   894 LQAEQRQQIEEQVDQIKELRQTEAE-----QLQLVARQSAEITQLQLQSEQFDQ-LLNSKEMSHE 952
            :: |:|..:......:.|..|...|     |.||:..:| ::.:.||:..|..| |.::.:..|.
Zfish   922 VR-EERDAVCSAQASVNEAHQRLTEDYSTAQHQLLQMES-DLLEAQLKETQLSQELSDNTQQLHN 984

  Fly   953 KQLEQQTRIRRELEAR---------------------AESLEGELSILQTL------VAEQKQQ- 989
            .|.|..|.:....||:                     :|.:|||...||:|      :.|:|||
Zfish   985 MQTENDTLLTSLQEAQQKCEQLSADLASVCAERDLLLSEKMEGESEELQSLRNTISSITEEKQQM 1049

  Fly   990 --LIESVSESEHAL------NLKML-----ELQSAQEELRELR--------AKEDPDQLREALRV 1033
              :::|:.|....|      |::|:     ||:.|||:::||:        .:.:||:.||
Zfish  1050 QEILQSLREQRDQLKTDLEENVEMMIETQAELRDAQEKVKELQGEINRLESGRVEPDEQRE---- 1110

  Fly  1034 SKSLVAQQVRELTSSQETVDALNQQIQEYQGLEHAHKEEQFKNRELREKLKKYALNLKKRTQDNA 1098
                           ...:|.|:|||                 ::|.|:|:...:..::...|.:
Zfish  1111 ---------------DGQMDTLHQQI-----------------KQLTEELQATVVEKERLLSDRS 1143

  Fly  1099 DLEQKVQ-ELTSQLQEQQELVKQKEEVEREPIVDNHRVEQLQQQVSKLNEDLKAKIH---LNLEN 1159
            :|.:|:. ::||..:::.||.::.:::||:.......:|:.:|.:.:|..:|:.|..   |:.:.
Zfish  1144 ELMEKMNTDVTSFTEQRSELQERLQQLERDSDTMKTHLEEKEQTILQLQSELQEKQQQQILDQDQ 1208

  Fly  1160 RDALRQLKQQIQEQEQLIQERDAELQDANLVSKELRRERQEADQEVFQLGQENSRLREE---ISK 1221
            :|...:...::|:.:.|.:|.:|.|:..|.::..|    :|:.|:|..:.:|...:|||   :..
Zfish  1209 QDFSEEKTDELQQIQTLKEELEAVLEQKNQLTLRL----EESAQQVCVVSEELRSVREERDAVCS 1269

  Fly  1222 LQEEIHNLGQRVN-EEPTAVEDLRRQ----LEAKSKKFEKSKELIKLRNATIQSLQRELQQLQQD 1281
            .|..:....||:. :..||...|.:.    |||:.|:.:.|:||        ....::|..:|.:
Zfish  1270 AQASVSEAHQRLTVDYSTAQHQLLQMESDLLEAQLKETQLSQEL--------SDNTQQLHNMQTE 1326

  Fly  1282 QDSEVEHVRNARAAHEQLRLEKDAEITALRQEILKLERSRAAGEGDDTITKTSHQLLESQSQQQA 1346
            .|:.:..::..:...||  |..|.......:::|..|:.....|...::..|...:.| :.||..
Zfish  1327 NDTLLTSLQETQQKCEQ--LSADLASVCAERDLLLSEKMEGESEELQSLRNTISSITE-EKQQMQ 1388

  Fly  1347 ESLQVAERELQQLRVQLTAAQEQHALLAQQYASDKANFEMTIARLETLHEGIQAKLQEDASYIES 1411
            |.||....:..||:..|   ::.:.:|.|      |..|....:::|.|:.:   ||:.....|.
Zfish  1389 EILQSLREQRDQLKADL---EDSNGMLMQ------AQLEHGGPQIDTPHDEL---LQQIQQLREE 1441

  Fly  1412 LEAQNTELQARSAALEEQAASQANQQ---AASQDKVQILEQQLKE-QREQEEQKRQQDQQLQERF 1472
            |:|.|.|.....:.|:|........|   .|:.|||:.|::.|:| |.:|:|.|.:.
Zfish  1442 LDATNEEKNQLKSDLQENVEMTIENQEELRAALDKVKDLQKSLEELQTKQQESKHKS-------- 1498

  Fly  1473 YELGQREQAQSRQLELLTSEAEESRQQLAGLRTEYESLLAKHSQLTAT-AQAEREQMSSHSQEE- 1535
                        ||||   :.::.|::|..:|.|.|.||::||..|.| |:..:..::|.::|:
Zfish  1499 ------------QLEL---QMQQLREELESVRHERERLLSEHSPNTHTDAEQMKADITSLTEEQE 1548

  Fly  1536 -----LAELRQQLDVKEADLHRQRQVYDAKLAAKATELDELECDLNSHVERAAAETRELCQQLER 1595
                 |.|||.||                 :..:.|.| :|..||.|           :|.:.||
Zfish  1549 QLQRTLQELRDQL-----------------MQTEQTVL-QLRADLES-----------VCAERER 1584

  Fly  1596 SQELVAQRTEELQRLNEEFQEVERERSTLSREVTLLRLQHDSAEQDVLELQELRMQAMQDKTEMD 1660
               |:..|:.:::.:.:....:..||..|.:.|..|..|.:...:|:.|.|::.:|
Zfish  1585 ---LLMDRSRDVEEMEKMSCRLTEERDALQQTVQQLSDQSEQLRRDLEENQDMVLQ--------- 1637

  Fly  1661 NLRTQIDALCANHSQELQALQQRIAELDTLGQNQTDDQVYIETENKRLAEQLSELQAQLARQQHQ 1725
             ||..:.::||...   :.|.::.::::.|              :.||.|:...||     |..|
Zfish  1638 -LRADLQSVCAERE---RLLTEKSSDMENL--------------SCRLTEERDALQ-----QTVQ 1679

  Fly  1726 QQQQQHHHPAVQSQQHPPPASLFFGGDALAAPSPFDEIAQPLRVSSLAASAPPPISPPPTIEDLQ 1790
            |.:.|.                                                       |.|:
Zfish  1680 QLKDQS-------------------------------------------------------EQLR 1689

  Fly  1791 RNVSDLEKHAQDLETKLLARNQNLAEQEERRLQLEQRLSEVERLLSERTQQLADIQTANEERDRL 1855
            |   |||:: ||:..:|             |..:|...:|.||||:||.|.||.|   .:||::|
Zfish  1690 R---DLEEN-QDMVLQL-------------RADVESGCAERERLLTERDQDLASI---TKEREQL 1734

  Fly  1856 AALEKLIQPAAAPTLDMFFGGQAE--------ETVPDAVSH---HLDLGLPQTEPVVEPLIQPKK 1909
                          ||:....:.|        |...:.:.|   .|:....:.:.:|..:.:.:|
Zfish  1735 --------------LDLLKANREEKNQLRTDLEENQENLLHLRQELESVSAEKDHLVSEMSREQK 1785

  Fly  1910 AYLCQPKQEIQEQTAQTIDWGVDEDPWASAANEAPQTDVEHLHTRIAQLELQLSNAEQQKTELQT 1974
            .:|.:.|...::.:|.|::           .::..:::.||..| |.||...|.:|..::..|..
Zfish  1786 EHLEEMKTTEEKLSAVTVE-----------RDQLMESNTEHNQT-IVQLRADLQSACAERDSLMV 1838

  Fly  1975 KAAKLMKRLKEYKTKATTTATPTVTVDNDLDSTI--IEEL-KHQLQLQESRLSKAEEISQQHALE 2036
            :             :..:::...::...||...:  :.|| :.|.:|::.:...::.:|..|. :
Zfish  1839 E-------------RDQSSSCSALSDGGDLQEILQGVRELIQVQGELKQKKHQHSDPLSPTHK-Q 1889

  Fly  2037 KEKLAKRIDVLTA-----GNDRMAEMKERQDMDV--QMYQARIRELQEKLSQLDQWGEPAATVSS 2094
            |.:| :::..||.     .|:||...|:.:|...  :|||..:...:|:|.|..:       .::
Zfish  1890 KAQL-QQLQSLTTEMESLRNERMVLRKDLEDAAATSKMYQELLHVSKEELKQQQK-------ENT 1946

  Fly  2095 SLDGDEAARIESLQQEIQQLRQQVSELEDERTRDQAELGALRQSSQGYDEAEDNQKLELQQLRQQ 2159
            .|....:||...|||::.:|.:.::.|:..|.:...|:                |:|: .:||..
Zfish  1947 ELMEQSSARETQLQQQLNELNEDLTALKVLRDQHDTEI----------------QRLQ-SELRSL 1994

  Fly  2160 ESELEALRTRDQSELEALRQSCQGHDETVRIATLQQDNQQLELQQLRQAIIELETLRARDQTELE 2224
            ..|.|.|..:.::|.|.||:..|         |||...::...:||.|::.|     .|||
Zfish  1995 SREKEDLLEKSRAEGELLRRDLQ---------TLQDQLEKSPTEQLLQSLTE-----ERDQ---- 2041

  Fly  2225 ALRQSSQGHDEAARIAIEQRDNQQLELQQLRQQLIELEALRARDQAELEALRQSCQGQQLSVDMA 2289
             ||:..||       .:|:..:.:.:.:||.:|.|.||       :|:.:|.||......||...
Zfish  2042 -LRRELQG-------KMEKLTHIETKAEQLEKQKILLE-------SEVHSLSQSLSEVNCSVSPD 2091

  Fly  2290 SRNDEQ----MAQLQEKESEIVHLKQRIEELM-----------RED------------------- 2320
            ..|.:.    ||.::..|.::.....:::::|           ||:
Zfish  2092 QNNTQSKHLIMAGIETSEEKLQTAFTKLQQIMERPVDQLSDVNREEWAVLYQLVPFIPKERRTIN 2156

  Fly  2321 -----QTEKLVFEILTKNQELQLLRMQV-----KQLEED----KEDQQ------VSAAPP----- 2360
                 :|.:|...|:...:..|.|..:.     .:|:.|    :|.:.      :|.||.
Zfish  2157 ATHTKKTTRLNHAIIKIAEAYQRLAHRFHTHFQTELQRDVCCFQESRLQDLLLCISPAPSQSLCS 2221

  Fly  2361 -KDDGETV--EKLKSLCQQLQQEKSDMEEELRVLNNHVLSSLEL--EDRMKQT-LLQLDTKNIEI 2419
             :||.:.:  ::|..|.::.||....:|..|.||...:....|:  |:|..:| .||      |:
Zfish  2222 LQDDFQQLWEQRLSHLLEKRQQYLQKLECVLVVLEEGLSRYAEMLSEERQHRTEELQ------EL 2280

  Fly  2420 TELRRS------LEILQSQNLGQNSAAE---------------QIPDLSAINQQWEQLVEQKCGE 2463
            ..|.||      :|:|:.|...::.|||               :|..|.:.:.:.|:.:|.:..:
Zfish  2281 KTLLRSAHADAVIELLERQISRRDKAAERLNTYYFVLLNKCDSEINPLKSSSSESERRLEDQRRQ 2345

  Fly  2464 VASIWQ-----------------EHLSQREAAFKAQLEEVTQQQQRELPQSQQSTQGEATSDIMQ 2511
            ..::.:                 :||||:.......:||: |:|.:||     ..|.:|::   |
Zfish  2346 TLTLLKAQNGTLPKTEAELLQDNQHLSQQLQQAHRHVEEI-QEQMKEL-----QVQADASN---Q 2401

  Fly  2512 KMQKALETQEMEIVTLKEQLAIRSAEYARLAAQYDPFRLQNRGGASGGNPASTTVSAGGPPSLTA 2576
            |..:.|  ||:.:..:::|..::|.|        |..|.......|...||::.::|
Zfish  2402 KQHEDL--QELRVQLMEKQNLVQSLE--------DKLRHSEALVKSSMTPAASELAA-------- 2448

  Fly  2577 NEPLPEYVLKADLDY-ALMMLHQRDMRVEEMIVELVQLLEERDHLQLKLSDTLR--QLETERSRV 2638
               |.:.::|.:|:: |:...|:::      |.::..:||.|..:..||.:|||  |.:.|:|..
Zfish  2449 ---LKDKLVKMELEHIAVTTSHEKE------ISQMSSMLEHRGDVIRKLKETLRKQQQDDEQSFT 2504

  Fly  2639 -SDEPSATASSSAASSSSPSKISSAGSNSELLGTTSAAGSDLKQKLAELQTVKHSKDKVIVDERE 2702
             .||.....||.|.::....|:                 .||::|.|:.:::. ||.:..:.:.:
Zfish  2505 DGDEFELKTSSRATTTLKEKKM-----------------EDLQKKNAQFESLV-SKQQEEISKWK 2551

  Fly  2703 QRLQQMLQLQKDMAKQGSGSQSGAGAVAAVAAPTS----AAPTAIGVDLSQSGLRSPSMMLMD 2761
            :|..:|.:.::|                |...||.    ..||.....|:::.:.||...::|
Zfish  2552 RRAYKMKESKRD----------------APCTPTKRDAPRTPTKRHPALAETEVNSPKRSVLD 2598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lva	NP_001284849.1	SMC_prok_B	327..1151	CDD:274008	197/931 (21%)
		SMC_prok_B	952..1721	CDD:274008	186/840 (22%)
		SMC_prok_B	1475..>2183	CDD:274008	150/735 (20%)
cenpe	NP_001314688.1	KISc	6..343	CDD:214526	47/247 (19%)
		KISc_CENP_E	6..337	CDD:276825	46/237 (19%)
		Myosin_tail_1	801..1826	CDD:279860	276/1281 (22%)
		CASP_C	984..>1100	CDD:285395	28/115 (24%)
		DUF342	<1430..1517	CDD:302792	28/112 (25%)
		SMC_prok_B	1468..2193	CDD:274008	201/984 (20%)
		GluZincin	1935..>2053	CDD:301352	40/167 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000