DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lva and Tnip2

DIOPT Version :9

Sequence 1:	NP_001284849.1	Gene:	lva / 31350	FlyBaseID:	FBgn0029688	Length:	2779	Species:	Drosophila melanogaster
Sequence 2:	NP_620703.1	Gene:	Tnip2 / 231130	MGIID:	2386643	Length:	430	Species:	Mus musculus

Alignment Length:	464	Identity:	108/464 - (23%)
Similarity:	188/464 - (40%)	Gaps:	111/464 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1168 QQIQEQEQLIQERDAELQDANLVSKELRRERQEADQEVFQLGQENSRLREEISKLQEEIHNLGQR 1232
            ||:|..:..:..|||.:  |:|.::....|...|...|..|..:..|.||::            |
Mouse    30 QQLQRLKDQLAARDALI--ASLRTRLAALEGHTAPSLVDALLDQVERFREQL------------R 80

  Fly  1233 VNEEPTAVEDLRRQLEAKSKKFEKSKELIKLRNATIQSLQRELQQLQQDQDSEVEHVRNARAAHE 1297
            ..||..:...||:::|..:::.|:.              :||:|||.    |:.:|
Mouse    81 RQEEGASETQLRQEVERLTERLEEK--------------EREMQQLM----SQPQH--------- 118

  Fly  1298 QLRLEKDAEITALRQEILKLERSRAAGEGDDTITKTSHQLLESQSQQQAESLQVAERELQQLRVQ 1362
                |::.|:..||:.:.:.|::|||   .|.:.::    |..::.|...:|.......|.|...
Mouse   119 ----EQEKEVVLLRRSVAEKEKARAA---SDVLCRS----LADETHQLRRTLAATAHMCQHLAKC 172

  Fly  1363 LTAAQEQHALLAQQYASDKANFEMTIARLETLHEGIQAKLQEDASYIESLEAQNTELQARSAALE 1427
            |...|     .||..|.:|:..|:.....:...:.:..||||          :|..|:.:...:|
Mouse   173 LDERQ-----CAQGDAGEKSPAELEQTSSDASGQSVIKKLQE----------ENRLLKQKVTHVE 222

  Fly  1428 EQAASQANQQAASQDKVQILEQQLKEQREQEEQKRQQDQQLQERFYELGQREQAQ-SRQLELLTS 1491
            :..|......|:..:.|:.|..|||.::...|.             ||.::|.:: :||||...|
Mouse   223 DLNAKWQRYDASRDEYVKGLHAQLKRRQVPLEP-------------ELMKKEISRLNRQLEEKIS 274

  Fly  1492 EAEESRQQLAGLRTEYESLLAK----HSQLTA------TAQAEREQMSSHSQE-------ELAEL 1539
            :..|:.|:|..:|...::.|.:    ..|:.|      :.:|:||:..|..||       .:.::
Mouse   275 DCAEANQELTAMRMSRDTALERVQMLEQQILAYKDDFKSERADRERAHSRIQELEEKIMSLMYQV 339

  Fly  1540 RQQLDVKEADLHRQRQVYDAKLAAKATELDELECDLNSHVERAAAETRELCQQLERSQE----LV 1600
            .|:.|.:|....|   ::.....||..|:|.||     ||...........||:|.|.|    ..
Mouse   340 SQRQDSREPGPCR---IHTGNKTAKYLEMDALE-----HVTPGGWRPESRSQQMEPSAEGGHVCT 396

  Fly  1601 AQRTE-ELQ 1608
            |||.: :||
Mouse   397 AQRGQGDLQ 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lva	NP_001284849.1	SMC_prok_B	327..1151	CDD:274008
		SMC_prok_B	952..1721	CDD:274008	108/464 (23%)
		SMC_prok_B	1475..>2183	CDD:274008	42/157 (27%)
Tnip2	NP_620703.1	SMC_N	25..>343	CDD:330553	87/392 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..202		3/18 (17%)
		Ubiquitin-binding domain (UBD)	290..348		11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..394		5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8279
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950