Protein Alignment lva and Golgb1

DIOPT Version :9

• Sequence 1: NP_001284849.1
• Gene: lva / 31350
• FlyBaseID: FBgn0029688
• Length: 2779
• Species: Drosophila melanogaster
• Sequence 2: NP_084311.1
• Gene: Golgb1 / 224139
• MGIID: 1099447
• Length: 3238
• Species: Mus musculus
• Alignment Length: 3390
• Identity: 697/3390 - (20%)
• Similarity: 1286/3390 - (37%)
• Gaps: 1021/3390 - (30%)

  Fly   108 VLKTRSGDSSTPLVSPTKDSDPGDVSLLQTSG----------------SEKLL-----MLTQR-- 149
            ||...|||.:...:..:.|:|....:.::::.                :|||:     :::|:
Mouse    12 VLHELSGDYTDWNLMASSDADSSQETAMESNNRIMESTQEDALHRLAEAEKLVVELKDIISQKDV 76

  Fly   150 --TEQNRALLEQRK---RDLAKSLLSVKSNIGHQTTAELGSSMTDLRHAASVSNPP------VSR 203
              .:::.||.|::|   ..:.|..|..|:.|     ..|...|.:::.....:.||      :|:
Mouse    77 QLQQKDEALQEEKKAAENKIKKIKLHAKAKI-----MSLNKHMEEIKTQGGAALPPEAQAEELSK 136

  Fly   204 HRSALDLEAQGQEAVDESRVK-LLRSRMKL-----TELKQGRQEQELNE----------LRTELA 252
            |.     ::..:|.::..::| .|:.:.||     .:|.|..|..:|::          ::.:|.
Mouse   137 HN-----KSSTEEEMEIEKIKHELQEKEKLISSLQAQLDQSEQASQLDKSSAEMEDFVLMKQQLQ 196

  Fly   253 KRAKLIERLELSGAELQRTLTQRNEELEQLRVVQAEEDS-----LKVQEN------------SRL 300
            ::.:||..|:   .:|.:|..::..:|..::.|..|:|:     :::.|:            :.:
Mouse   197 EKEELISTLQ---TQLSQTQAEQAAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQSDVETEM 258

  Fly   301 QGEVLVLRERLAELE-------NVNDLLETTRCELQEELTTARERQRNLELEQEQEKASRSPQSE 358
            |.::.|::.:|.|.|       .|.||       ||:|||:|.:|.:.|..:.:..:|..:....
Mouse   259 QQKLRVMQRKLEEHEEALLGRAQVVDL-------LQKELTSAEQRNQVLSQQLQLLEAEHNTLKN 316

  Fly   359 AAHTDAQVSAELAKQLQ-----------ELTNQLADLQATNEELRQQVAAQAKLQVTDEIVSQR- 411
            ...|:.|.|..|.::::           .|..::..||...|...|   |||.|:.....:.||
Mouse   317 TMETERQESKTLMEKVELEVAERKLSFHNLQEEMHQLQGQLERAGQ---AQADLETQYSALQQRH 378

  Fly   412 ---LEELEATIAAQLLELQEQKSAMAAQNEELAEKTTELNVLNVNLRLLEEKLAQSSRSKPLFLE 473
               :||..|.|.:.....||.:||.||..||             |.:||:||..|:
Mouse   379 KTEMEEKTACILSLQKNEQELQSACAALKEE-------------NSKLLQEKHDQA--------- 421

  Fly   474 DHSEDSAASKQMQEDLQQLKLKLDE-TNKANIKLKLKCKQA---------------------EKK 516
              :|.:.|.:|:::.|||...::.: .||.|::......|.                     :|:
Mouse   422 --AESAQAMRQLEDQLQQKSKEISQFVNKPNLQKNETASQTSLPDVNNEGDQAVMEETVASLQKR 484

  Fly   517 LQKFQSQDGQQQLAS-----LLADNEELQQRIAVLEDEKGQWQLAN------------MQEDDRQ 564
            :.:.:::.|...|:|     |.|:||:|..||.:||.:....:...            :...|..
Mouse   485 VVELENEKGALLLSSGELEELKAENEKLSSRITLLEAQNRAGEADGTVCEVSTAGTTLLNRSDSS 549

  Fly   565 PE-------QSTESNNPLQLETIRLLEEQKLELQQA---LEALLSSSSSAESIEIVERHHLECLG 619
            ||       ::|.|....:|..  ||.|.| |.|:.   |::.|.........|:::|..::.:.
Mouse   550 PEENGQAVLENTFSQKHKELSV--LLVEMK-EAQEEIAFLKSQLQGKRPEGDYEVLDRREVQLME 611

  Fly   620 QRRP--------------ASEGDAQEQKQ--------VHPPGP---------------------- 640
            ...|              .|.|.|.|::|        ....||
Mouse   612 SEGPPSVTAGDVLCAPSDESSGPAAEEEQAGMKDRHRASEAGPLNDAGMELSSPKLDGVDKSLAV 676

  Fly   641 SHVSELTQTE---------------QTEEE--------------------DSSGETLSQLRERLE 670
            |||.:..|.|               .|.||                    :...|:..:.|..|.
Mouse   677 SHVCQCHQGELERLKTQVLELETSLHTAEETYKRNLSEKVKEISSLTQLSEEVKESAEEARSTLA 741

  Fly   671 LFTQERGEVLDKLEQLSAENLQLQARLEESSSSLQLLQREREKDLISSTSTSSNLSQELSSMQ-- 733
            ..|:||.::|.::::|.. ..:|:||::|..|||...:::|..|..|..:..:.|::::.|:.
Mouse   742 AVTEERDQLLYQVKELDV-LAELRARVQELESSLAEAEKQRGLDYESQRAQHNLLTEQIHSLSIE 805

  Fly   734 -RSSEVVATLDAGEGGPVLFEKCEK--SLSKLNSELEA----YRKANDRQAKFNVSKKLAKEAKN 791
             :|.:|.......|...|..:.||:  .:..|.|:|||    .|:..:|      .:.:::|.:.
Mouse   806 AKSKDVKIEALQRELDGVQLQFCEQGTQMKTLQSQLEAKEREVREGTER------LRDISQEMEG 864

  Fly   792 CHTQLSE-----------LLHKVKEASTAVETVTVVETVVAVTAPNGKALAEYEQLNAQNAELKA 845
            ....||:           ||.|.|:..|..:|:.  |....||..:.....:..|||.:...|..
Mouse   865 LSQALSQKELEIAKMDQLLLEKQKDVETLQQTIQ--EKDQQVTELSFSMTEKMVQLNEEKFSLGV 927

  Fly   846 VISRLRQELDELRESYPETEAPLAIVGSDSQRE---DEILQ--LQSQLEDARSLQAEQRQQIEEQ 905
            .|..|:::|:.|..:...|:..:...|:.|..:   ||..|  ||.:||..|....:::::::..
Mouse   928 EIKTLKEQLNLLSRTEEATKEQVEESGAGSSLKLGHDESGQEGLQQELELLRKESEQRKRKLQAA 992

  Fly   906 VDQIKELRQTEAEQLQLVARQSAEITQLQLQSEQFDQLLNSKEMSHEKQLEQQTRIRRELEARAE 970
            :...|||.|              :::||:      ::|...:|.| .|::......||:||...|
Mouse   993 LINRKELLQ--------------KVSQLE------EELAKVREDS-RKEIPFGENERRKLEEDRE 1036

  Fly   971 SLEGELSILQTLVAEQKQQLIESVSESEHALNLKMLELQSAQEELRELRAKEDPDQLREALRVSK 1035
            :.:.......:...|.:..|.:::||.|       :||:..:.:|:|..|.|:..|
Mouse  1037 NRDDPEEWGTSKWREVEASLKQTISEKE-------VELEGIRRDLKEKTAAEEELQ--------- 1085

  Fly  1036 SLVAQQVRELTSSQETVDALNQQIQEYQGL----------------------------EHAHKEE 1072
            ::|.:..|:|.|..:.:|.|.:::.|.|..                            ..|..||
Mouse  1086 AVVQRMTRDLQSKTKQIDLLQEEVTENQATIQKLVTGTMDAGNGGSAAPVKETAASSPPGAGGEE 1150

  Fly  1073 QFKNRELREKLKKYALNLKKRTQDNADLEQKVQEL----TSQLQEQQELVKQ-KEEVEREPIVDN 1132
            .:|     .:|:...|:|:|   |...|::|:||.    .:.|::.||..|| |||:..:....:
Mouse  1151 HWK-----PELEGRILDLEK---DKTQLQKKLQEALIARKAILKKAQEKEKQLKEELREQKDAYH 1207

  Fly  1133 HRVEQLQQQVSKLNEDLKAKIHLNLENRDALRQLKQQIQE-----------QE------------ 1174
            |...|..:| :|..|::          .|.||||:.|.:|           ||
Mouse  1208 HLQGQFHEQ-NKEKENI----------ADQLRQLQCQARESIDRQLPGTGQQEPGPPAPSLEGIS 1261

  Fly  1175 ----QLIQERD------------AELQDANLVS------KELRRERQEADQEVFQLGQENSRLRE 1217
                :...|.|            |.||....|:      ||:..|::|.:.:|..:..|.::..|
Mouse  1262 LEDTEPASESDLHAAQPSPPGETAALQATVSVAQIQAQLKEMEVEKEELELKVSSIASELAKKSE 1326

  Fly  1218 EISKLQEEIHNLGQRVNEEPTAVEDLRRQLEAKSKKFEKSKELIKLRNAT-IQSLQRELQQLQQD 1281
            |:..||::|:..|..:.....|..:.:...|...::.|.|:  :|:.... :::||.||..|.:.
Mouse  1327 EVLLLQDQINEQGLEIQNLKAASVEAQAHTELLKQELESSQ--LKVAGLEHLKTLQPELDALHKH 1389

  Fly  1282 QDSEVEHVRNARAAHEQLRLEKDAEITALRQEILKLERSRAAGEGDDTITKTSHQLLESQSQQQA 1346
            ...:.|.|   ...:.||. ||:..:|.::.|:::.||          :.|..|..||.|:::..
Mouse  1390 MGQKEEEV---NYLYGQLS-EKEQTLTTVQTEMVEQER----------LIKALHTQLEMQAKEHE 1440

  Fly  1347 ESLQVAERELQQLRVQLTAAQEQHALLAQQYASDKANFEMTIARLETLHEGIQAKLQED-ASYIE 1410
            |.|:.|:.|:.:|:.:.|..:|:  ..|:|....|....: |:|.|.|.|  ...|||. :|..:
Mouse  1441 ERLKQAQVEICELKKKPTELEEE--TNAKQQLQRKLQAAL-ISRKEALKE--NKSLQEQLSSARD 1500

  Fly  1411 SLEAQNTELQARSAALEEQAASQANQQAASQDKVQILEQQ------------------------- 1450
            ::|.....|    |.:|.|.:.|..::.|...|:.||:::
Mouse  1501 AVERLTKSL----ADVESQVSVQNQEKDAVLGKLTILQEERDKLIAEMDRFLLENQSLSGSCESL 1561

  Fly  1451 ------LKEQREQ--EE------QKRQQDQQLQERFYELGQREQAQSRQLELLTSEAEESRQQLA 1501
                  |.|.:|:  ||      .|..:..:.||:..||.:..:...:..|.:::|||..:..:.
Mouse  1562 KLALGGLTEDKEKLMEELESVRSSKMAESTEWQEKHKELQKEYEVLLQSYENVSNEAERIQHVVE 1626

  Fly  1502 GLRTEYESLLAKHSQLTATAQAEREQMSSHSQEELAELRQQLDVKEADLHRQRQVYDAKLAAKAT 1566
            .:|.|.:.|.|| .:.|.:.:.|||:....:::|:.|:::::                :..||:.
Mouse  1627 SVRQEKQELYAK-LRSTESDKREREKQLQDAEQEMEEMKEKM----------------RKFAKSK 1674

  Fly  1567 ELDELECDLNSHVERAAAETRELCQQLERSQELVAQRTEELQRLNEEFQEVERERSTLSREVTLL 1631
            :...||  |....:|..||.:.:....|..:.|::..:.    |.||.:::..|..|||:|...|
Mouse  1675 QQKILE--LEEENDRLRAEAQPVGGTGESMEALLSSNSS----LKEELEKITLEHKTLSKEFEAL 1733

  Fly  1632 RLQHDSAEQDV------LELQELRMQAMQDKTEMDNLRTQI--------------DAL------- 1669
            ..:.|:..::.      :|.|.|:..:::...:.|..:..|              |||
Mouse  1734 MAEKDALSEETRNLKLQVEAQVLKQASLEATEKSDEPKDVIEEVTQAVVGKSQERDALSDSAKLE 1798

  Fly  1670 ------------------------CANHSQELQALQQRIAELDTLGQNQTDDQVYIETENKRLAE 1710
                                    ..|:.|:|..|:.|||||:...|...:....:|.|...|..
Mouse  1799 DSEAILMGDGAKPGVSETFSSHDDIKNYLQQLDQLKGRIAELEMEKQKDRELSQALENEKNALLT 1863

  Fly  1711 QLS---------------------ELQAQLARQQHQQQQQQHHHPAVQSQQHPPPASL-----FF 1749
            |:|                     ::|.:|.|....::..:.....::.:.....|.|     .:
Mouse  1864 QISAKDSELKLLEEEVTKRTTLNQQIQEELCRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1928

  Fly  1750 GGDALAAPSPFDEIAQPLRVSSLAASAPPPISPPPTIEDLQRNVSDLEKHAQDLETKLLARNQNL 1814
            ..|...|....:::...:|                   :|||.||:||:..|.     |.:.:..
Mouse  1929 YQDVTDAQIKNEQLESEMR-------------------NLQRCVSELEEEKQQ-----LVKEKTK 1969

  Fly  1815 AEQEERRLQLEQ------------RLSEVERLLSERTQQLADIQ-TANEERDRLAALEK------ 1860
            .|.|.|:..:|:            ...|::.||.|:.|::..:| ......:|::||||
Mouse  1970 VESEIRKEYMEKIQGAQKGPANKSHAKELQELLREKQQEVKQLQKDCIRYLERISALEKTVKALE 2034

  Fly  1861 LIQPAAAPTLDMFFGGQAEETVPDAVSHH-------------LDLGLPQTEPVVEPLIQPKKAYL 1912
            .:...:...||:..|..|:     ||.|.             ||....:...|:...::.||. |
Mouse  2035 FVHTESQKDLDVTKGNLAQ-----AVEHRKKAQAELSSFKILLDDTQSEAARVLADNLKLKKE-L 2093

  Fly  1913 CQPKQEIQEQTAQTIDWGVDED-----PWASAANEAPQTDVE-----------HLHTRIAQLELQ 1961
            ...|:.|:.|..|.     |||     ..|...:...:.:::           |:...:|::::.
Mouse  2094 QSNKESIKSQIKQK-----DEDLLRRLEQAEEKHRKEKKNMQEKLDALHREKAHVEETLAEIQVS 2153

  Fly  1962 LSNAEQQKTELQTKAAKLMKRLKEYKTKATTTATPTVTVDNDLDSTIIEELKHQLQLQESRLSKA 2026
            |:..:|:..|||......:.:|..: ||:.:      ::.:|.|..|.|..|.:.:..::..:|.
Mouse  2154 LTRKDQEMKELQGSLDSTLAQLAAF-TKSMS------SLQDDRDRVIDEAKKWERRFGDAIQTKE 2211

  Fly  2027 EEISQQHALEKEKLAKRIDVLTAGNDRMAEMK---ERQDMDVQMYQARIR-ELQEKLSQLDQWGE 2087
            ||:    .|::|......|.|......|.|:|   .|.:.|.::::::.: |||......|:..|
Mouse  2212 EEV----RLKEENCIALKDQLRQMAIHMEELKITVSRLEHDKEIWESKAQTELQHHQKAYDKLQE 2272

  Fly  2088 PAATVSSSLDG------DEAARIESLQQEIQQLRQQVSELED--ERTRDQAE--LGALRQSSQGY 2142
            ....::|.|:.      |....:..|:.|::.|:.|.::|.:  |:.::...  .|.::|
Mouse  2273 ENKELTSQLEDARQLYHDSKNELTKLESELKSLKDQTTDLNNSLEKCKEHENNLEGIIKQ----- 2332

  Fly  2143 DEAE-DNQKLELQQLRQQESELEALRTRDQSELEALRQS----CQGHDETVRIAT---LQQDNQQ 2199
            .||: .|.|...:||....:....|.:|...|:.|..|.    ..|.:|.:::|.   .||.:::
Mouse  2333 QEADIQNCKFSCEQLETDLAASRELTSRLHDEINAKEQKIISLLSGKEEAIQLAVEELHQQHSKE 2397

  Fly  2200 L-ELQQL------RQAIIELETLRARDQTE-----LEALRQS---------------SQGHDEAA 2237
            : ||:.|      ....:|.|..||.::|.     |||:::.               |...|:..
Mouse  2398 IKELENLLSQEEEENVALEEENKRALEKTNQLTEALEAIKKESFEQKAQLDSFVKSMSSLQDDRD 2462

  Fly  2238 RIAIEQRDNQQLELQQL--RQQLI------------ELEALRA--------------------RD 2268
            ||..:.|..::..|..:  :.|||            |:..||:                    ||
Mouse  2463 RIVSDYRQLEERHLSAILEKDQLIQDAAAENNKLKEEMRGLRSHMDDLNSENAKLDAELVQYRRD 2527

  Fly  2269 QAELEALRQSCQGQQLSVDMASRNDEQMAQLQEKESEIVHLKQRIEELMREDQTEKLVFEILTK- 2332
            ..|:.|::.|.|.|.|        |.|:.|.:|..:|...|::|::.|..|.|:.::..:.|.|
Mouse  2528 LNEVIAIKDSQQKQLL--------DAQLQQNKELRNECTKLEERLKGLEAEKQSLQMSSDALQKE 2584

  Fly  2333 ----NQELQLLRMQVKQLEEDKEDQQVSAAPPKDDGETVEKLKSLCQQLQQEKSDMEEELRVLNN 2393
                ::|::.|:.|:..|:|: ....|..|..|...|.:::|.......|:..:|:||||..:..
Mouse  2585 KQGLSKEIKNLQTQLTALQEE-GTLGVYHAQLKAKEEELQRLNMALSSSQKRTADLEEELVCVQK 2648

  Fly  2394 HVLSSL-ELEDRMKQTLLQL-----------DTKNIEITELRRSLEILQSQNL------------ 2434
            .....: |:||::|:.|..|           :|....:.||.|.|..::.:.|
Mouse  2649 EATRKVSEIEDQLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLTVTKENKDLMAQ 2713

  Fly  2435 -------------GQNSAAEQIPD----------------------------------------- 2445
                         .::.|.|::.|
Mouse  2714 IQAFGRSMSSLQDSRDHATEELGDLKKKYDASLKELAQLKEWQDSSREGDVLSQAAFPLSTSENV 2778

  Fly  2446 ---LSAINQQW----EQL------VEQKCGEVASI--------------W--------QEHLSQR 2475
               |..:|||.    |||      :|....:|.||              |        .|...||
Mouse  2779 LSRLEKLNQQLTSKDEQLLHLSSELESSHNQVQSISKAMTSLQNERDRLWSELEKFRKSEEGKQR 2843

  Fly  2476 EAAFKAQ-----------------------LEEVTQQQQRELPQSQQSTQGEATSDIMQKMQ--- 2514
            .||..|.                       |:|:...||:.|..||:.|:.......:|:.|
Mouse  2844 AAAPSAASSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQMSQEMTELRPLKAQLQESQDQT 2908

  Fly  2515 KALETQEMEI-------------------------VTLKEQL-------------------AIRS 2535
            |||:..|.|:                         ..:|||.                   .:||
Mouse  2909 KALQVMEEELRQENLSWQHELRQLRMEKNSWELHERRMKEQFLMAISDKDQQLGHLQSLLRELRS 2973

  Fly  2536 AEYAR-LAAQYDPFRLQNRGGASGGNPASTTVSAGGPPSLTANEPL--PEYVLKADLDYALMMLH 2597
            :..|: |:.||.             ..||...||    ||..::.|  ...:|:..|:.:|..:|
Mouse  2974 SSQAQILSTQYQ-------------RQASPETSA----SLDGSQKLVYETELLRTQLNDSLKEIH 3021

  Fly  2598 QRDMRVEEMIVELVQLLEERDHLQLKLSD---TLRQ--------------LETERSRVSDEPSAT 2645
            |:::|::::..:..|||||::.|..:|||   :||:              ||.|..::...|..|
Mouse  3022 QKELRIQQLNSKFSQLLEEKNVLSTQLSDASQSLRENQHHYSNLFNHCAILEKEVQKLQAGPLNT 3086

  Fly  2646 ASSSAASSSSPSKISSAGSNSELLGTTSAAGSDLKQKLAELQTVKHSKDKVIVDEREQRL--QQM 2708
            ..:..|......  ....|..|..|....:.|:::|:|...:.......|::.:||:|||  :..
Mouse  3087 DVAPGAPQEKNG--MHRKSEPETTGEEQPSFSEVQQQLCNTKQDLRELKKLLEEERDQRLTAENA 3149

  Fly  2709 LQLQKDMAKQ 2718
            |.|.|:..::
Mouse  3150 LSLAKEQIRR 3159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lva	NP_001284849.1	SMC_prok_B	327..1151	CDD:274008	222/1024 (22%)
		SMC_prok_B	952..1721	CDD:274008	203/959 (21%)
		SMC_prok_B	1475..>2183	CDD:274008	166/851 (20%)
Golgb1	NP_084311.1	SMC_prok_B	<56..428	CDD:274008	89/418 (21%)
		SMC_prok_B	<309..1037	CDD:274008	167/787 (21%)
		PRK12704	1167..>1242	CDD:237177	24/85 (28%)
		SMC_prok_B	1331..2164	CDD:274008	183/915 (20%)
		Smc	1837..2656	CDD:224117	181/878 (21%)
		Smc	2269..3057	CDD:224117	167/818 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000