Protein Alignment lva and T28C6.7

DIOPT Version :9

• Sequence 1: NP_001284849.1
• Gene: lva / 31350
• FlyBaseID: FBgn0029688
• Length: 2779
• Species: Drosophila melanogaster
• Sequence 2: NP_001294054.1
• Gene: T28C6.7 / 177697
• WormBaseID: WBGene00012121
• Length: 2318
• Species: Caenorhabditis elegans
• Alignment Length: 2903
• Identity: 630/2903 - (21%)
• Similarity: 1098/2903 - (37%)
• Gaps: 909/2903 - (31%)

  Fly    30 RLAGSSNDLSSLQNVSASTTRGTKGKGRLDSLKENLYKQQERLTALKERALRKSQDE-----RHK 89
            :|....|.:..|.||.....|      ::..|:|.: ::...:.::|.:|:|..|.:     |.|
 Worm    24 QLVYKDNRIIDLNNVILDKER------QILDLQERV-REHNEVASVKNQAMRIVQQKFEEMNRDK 81

  Fly    90 SSMSDSME-SL-----------------------KTLGQKLTVLKTRSGDSSTPLVSPTKDSDPG 130
            ..||...| ||                       ..:.|:.|::.:.||..|.|.:.|..|.
 Worm    82 KDMSTETEPSLMAHSSVPLSNSKSERRARSSSPGHVIAQRKTMVSSSSGTFSPPPLDPPFDP--- 143

  Fly   131 DVSLLQTSGSEKLLMLTQRTEQNRALLEQRKR---DLAKSLLSVKSNIGHQTTAELGSSMTDLRH 192
                     |.||..|......:|.  .||||   ||..:    .|:||..|::...|:
 Worm   144 ---------SSKLSALPDIDGIHRK--HQRKRVTFDLNPN----GSSIGTSTSSNFPST------ 187

  Fly   193 AASVSN-PPVSRHRSALD-LEAQGQEAVDESRVKLLRSRMKLTELKQGRQEQELNELRTELAKRA 255
              |||. |.:|...|..| ||:...||..|:.:    .|.::.||....::.:. :..:|:.|..
 Worm   188 --SVSRYPTISMSSSTSDALESALTEASSENAL----LRQQVIELNSSVEKMKA-DYESEILKYT 245

  Fly   256 KLIERLELSGAELQRTLTQRNEELEQLRVVQAEEDSLKVQENSRLQGEVLVLRERLAELENVNDL 320
            |   ..:.:|.:.:...|.|.:|||                               ..||::|..
 Worm   246 K---EAKTAGLKAKVAATARIKELE-------------------------------TTLEDINGK 276

  Fly   321 LETTRCELQEELTTARERQRNLELEQEQEKASRSPQSEAAHTDAQVSAELAKQLQELTNQLADLQ 385
            .|..|..||||:.|.|. .||.|:||     :...:.:.||        |.:::.:||.:|...:
 Worm   277 YEDERDRLQEEVDTLRS-SRNWEIEQ-----NALLRDQVAH--------LKEKVHKLTTELDASE 327

  Fly   386 ATNEELRQQVAAQAKLQVTDEIVSQRLEELEATI-------AAQLLELQEQKSAMAAQNEELAEK 443
            .....|..:|....||.   |::.:.|.:.|:.|       .|...::...|.|:.||:..:...
 Worm   328 VAKRSLSSEVDESKKLM---ELMVEDLLQAESAINYNQCQKKAIFEDIDRLKDAIQAQDRFIEVL 389

  Fly   444 TTELNVLNVNLRLLEEKLAQSSRSKPLFLEDHSEDSAASKQMQEDLQQLKLKLDETNKANIKLKL 508
            ..::.:...::.||.|.|..|.       .|| .....||..:..|..|:.:.::::|.:.:.:|
 Worm   390 EADIVIYEQHIGLLRENLGASQ-------VDH-RALIKSKAFETKLLALEREKEQSDKKSNEDRL 446

  Fly   509 KCKQAEKKLQKFQSQDGQQQLASLLADNEELQQRIAVLE------DEKGQWQLANMQEDDRQPEQ 567
            |.|..:||.:            .|:..||:|..|:..||      ||..:.:||..:|..||...
 Worm   447 KTKALDKKCR------------VLVEQNEQLMARLCELEMSHGGADETRERRLAEQEERIRQISS 499

  Fly   568 STESNNPLQLETIRLLEEQKLELQQALEALLSSSSSAESIEIVERHHLECLGQRRPASEGDAQEQ 632
            :.||..               ::.|.|.         |:.|::|:   |.:.:::.....:.:.|
 Worm   500 ALESER---------------DVGQRLR---------EAKEVLEK---ELMNKKKTEEASNNRFQ 537

  Fly   633 KQVHPPGPSHVSELTQTE-QTEEEDSSGETLSQLRERLELFTQERGEVLDKLEQLSAENLQLQAR 696
            :.|         |:::.| |.:.|:.|.|        ::...::..|||.::|||.|.|..||..
 Worm   538 RDV---------EMSRMEAQNKIEEMSVE--------VDAAHKKVNEVLSEVEQLRATNFDLQMH 585

  Fly   697 LEESSSSLQLLQREREKDLISSTSTSSNLSQELSSMQRSSEVVATLDAGEGGPVLFEKCEKSLSK 761
            :|                      |:....:||:.                       |.:.|.|
 Worm   586 IE----------------------TAKRTMEELAD-----------------------CNEELEK 605

  Fly   762 LNSELEAYRKANDRQAKFNVSKKLAKEAKNCHTQLSELLHKVKEASTAVETVTVVETVVAVTAPN 826
            ...|.|...:..|..                          :|:::..|||:|
 Worm   606 RVDEYEEAAEEKDED--------------------------LKQSTWDVETLT------------ 632

  Fly   827 GKALAEYEQLNAQNAELKAVISRLRQELDELRESYPETEAPLAIVGSDSQREDEILQLQSQLEDA 891
                       .||   :|:....|.|||.:|:.:.||.          :..||:..|:|:|
 Worm   633 -----------RQN---EALSPNFRVELDGVRQGFHETR----------ELADEVKHLRSEL--- 670

  Fly   892 RSLQAEQRQQIEEQVDQIKELR--QTEAEQLQLVARQSAEITQLQLQSEQFDQLLNSKEMSHEKQ 954
                  ||||         |:.  |.:|...::.|.:....|.|::|.:|:......|..:..::
 Worm   671 ------QRQQ---------EIHRAQFDAACREMDADEPERKTSLEVQQDQYILAYEEKIRTMSQE 720

  Fly   955 LEQQTRIRRELEARAESLEGELSILQTLVAE----QKQQLIESV----------SESEHALNLKM 1005
            :|   .::||||.:    .|.:....|.|.|    ::.|:::.|          |||.|  ..:|
 Worm   721 ME---ALKRELELK----NGPVQRKTTQVLEPPSIEQIQMVQPVQMTTSAAPQASESSH--QYEM 776

  Fly  1006 LELQSAQEELRELRAKEDPDQLREALRVSKSLVAQQVRELTSSQETVDALNQQIQE-YQGLEHAH 1069
            ....|:.|:.|...:...|.|.         ||.|..:...|||:..|   |.::| ::.|:...
 Worm   777 TTSTSSSEKRRAPVSAPLPAQY---------LVQQSQQAPQSSQQNED---QVLREAHENLKRQV 829

  Fly  1070 KEEQFKNRELREKLKKYALNLKKRTQDNADLEQKVQELTSQLQEQQELV-KQKEEVEREPIVDNH 1133
            .|.:.||.:..||:.:..:..|...:.|.:|.:.:.|    |:|..||: |::|.|..:....:.
 Worm   830 DELKKKNADFSEKMMRLEMEAKLSGELNVELGRAMLE----LEEHNELLQKEQEAVTADDTATSR 890

  Fly  1134 RVEQLQQQVSKLNEDLKAKIHLNLENRDALRQLKQQIQEQEQLIQERDAELQDANLVSKELRRER 1198
            .:|.....|.::.|.: |.:|   |..|.:.:||     .||:               |||.:.:
 Worm   891 ELELHVLMVQEMTEQI-ASMH---EKNDEMEKLK-----VEQM---------------KELEKWK 931

  Fly  1199 QEADQEVFQLGQENSRLREEISKLQEEIHNLGQ------------------RVNEEPTAVEDLRR 1245
            .||    |...||..|:..|:.:|   :|.|.:                  .:.|....:||.||
 Worm   932 SEA----FTSKQEAQRVHAEVQRL---LHALSESELARKSEFEQATTAHDAEIREFSIKMEDARR 989

  Fly  1246 QLEAKSKKFEKSKELIKLRNATIQSLQRELQQLQQDQ----DSEVEHVRNARAAHEQLRL----- 1301
            .:.....|.::::|.:|.....::.: .|...||:.:    .|.:.:..:.:.:||.:..
 Worm   990 DIADLEAKLQEAEEKLKTVQVPVEMI-CETPFLQETRILTSSSPLGNQSDTQKSHEAVESSNTNP 1053

  Fly  1302 EKDAEITALR---------QEILKLERSRAAGEGDDTITKTSHQLLE---------SQSQQQA-- 1346
            :||..:.|.|         ..:..||.|..    |..:...:..:.|         .|.|||.
 Worm  1054 QKDTNVIASRVSSTSQLAPGHLGSLEVSHR----DSNVPDAAQMMPEPSASDLEILQQDQQQTLL 1114

  Fly  1347 ESLQVAERELQQLRVQLTAA-----QEQHALLAQQYAS--DKANFEMTIARLETLHE-------G 1397
            .|:.....:|.:|:.:|..|     .|..:|..|..||  |:...|..:.:|:.:.|       .
 Worm  1115 HSVSQDMNKLIELKDELEIAVQALKAEIWSLNGQLKASILDREGLEDKVTQLDDMVEKEKKRAID 1179

  Fly  1398 IQAKLQEDASYIESLEAQNTELQARSAALEEQAASQANQQAASQDKVQILEQQLKEQREQEEQK- 1461
            :..:|||        :...|:...|.||   :|.:::||:.|     :.||   ||.|.:|.:|
 Worm  1180 LDVELQE--------QIDLTDRAVRRAA---EAENESNQRMA-----ECLE---KETRREEIEKA 1225

  Fly  1462 ----RQQDQQLQERF---YELGQREQAQSRQLEL-----------LTSEAEESRQ--QLA-GLRT 1505
                .:...||||.:   |......||.:.::.|           ||||:.|..|  ||. ||.|
 Worm  1226 YTRLNEYYNQLQEAYNNVYAQLAALQAANAEVPLTSTLSATTAPPLTSESSEPSQFAQLVDGLMT 1290

  Fly  1506 EYESLLAKH--SQLTATAQAEREQMSSHSQEELAELRQQLDVKEADLHRQRQVYDAKLAAKATEL 1568
            ..  |::::  |.:|.:...:.||:.    ::|.:|..:.:..:..|..||::.:|  ..|..:.
 Worm  1291 IL--LISQNSPSDITISTHQKLEQVG----KKLKQLLSEYEENQNALDEQRKITEA--LEKRLQA 1347

  Fly  1569 DELECDLNSHVERAAAETRELCQQLERSQELVAQRTEELQRLNEEFQEVER------ERSTLSRE 1627
            .|...|....|    ..|:|..:|||..   :..:.||.:.|....:|:|:      ||:..:..
 Worm  1348 SESARDAPDDV----MMTKERVEQLEGE---IEWKEEECEGLKRRIRELEKALEAVAERADETEA 1405

  Fly  1628 VTLLRLQHDSAEQDVLELQELRMQAMQDKTEMDNLRTQIDALCANHSQELQALQQRIAELDTLGQ 1692
            ..:.||   |.|..:|..:....||            .:|:|...:::        :|..:...|
 Worm  1406 AAVCRL---STELAILAAKLTTRQA------------DVDSLFRTNAE--------LAHTNVRLQ 1447

  Fly  1693 NQTDDQ----VYIETENKRLAEQLSELQAQLAR--QQHQQQQQQHHHPAVQSQQHPPPASLFFGG 1751
            |:.|:|    ..||.|.::|.:.:.||:.|:|.  :||:...:|
 Worm  1448 NEVDEQDEWKAKIEEEKEQLEQHVKELEDQVAELMEQHETHFRQ--------------------- 1491

  Fly  1752 DALAAPSPFDEIAQPLRVSSLAASAPPPISPPPTIEDLQRNVSDLEKHAQDLET--KLLARNQNL 1814
                        ||.|:.::.:|:.          |::.: |.|.||..|.|..  |:|  |..:
 Worm  1492 ------------AQLLQSATSSANT----------ENISK-VHDSEKEVQRLSAIEKIL--NNRI 1531

  Fly  1815 AEQEERRLQLEQRLSEVE-RLLS---------------------------ERTQQLADIQTANEE 1851
            ...|::.|:||::..|:| .:||                           |..::|.:   |..|
 Worm  1532 LALEDQNLELEEKYQEMEDEMLSLKQDSTKKSEIVAGTSNWEDSWDEKGDENAKELVE---ARNE 1593

  Fly  1852 RDRLAALEKLIQPAAAPTLDMFFGGQAEETVPDAVSHHLDLGLPQTEPVV---EPLIQPKKAYLC 1913
            .:||..:||      |.||.|               ..|.:...|.|..|   |.:.:...:::.
 Worm  1594 VERLLDVEK------ALTLRM---------------EMLQIQNVQLESRVREQEDVNKSVTSHVR 1637

  Fly  1914 QPKQEIQEQTAQTIDWGVDEDPWASAANEAPQTDVEHLHTRIAQLELQLSNAE-QQKTELQTKAA 1977
            ||:...|          |:||.|.....:.|.|.::.........|.|....| .:||||.
 Worm  1638 QPESSDQ----------VEEDDWGWGEEKEPTTTIQKRDDDWGWDETQEEPKELSEKTELD---- 1688

  Fly  1978 KLMKRLKEYKTKATTTATPTVTVDNDLDSTIIEELKHQLQLQESRLSKAEEISQQHALEKEKLAK 2042
               |.|:|.|::...    .|.::..|::.|:......|:|:| ||.:.||    ..|:::...|
 Worm  1689 ---KELQEAKSEIGR----LVEIEKVLNNRILSLEDQNLELEE-RLQEMEE----ELLDEKNKKK 1741

  Fly  2043 RIDVLTAGNDRMAEMKERQDMDVQMYQARIRELQEKLSQLDQWGEPAATVSSSLDGDEAARIESL 2107
            .:|                        |::.:..|:  ....|||         |..|||...::
 Worm  1742 EVD------------------------AKVEQKSEE--NWGDWGE---------DDAEAATESNV 1771

  Fly  2108 QQEIQQLRQQVSELEDERTRDQAEL-----GALRQSSQGYDEAEDNQKLELQQLRQQESELEALR 2167
              .:..|:..|:||:| |.:.|.|:     ..|.::.:.|||.|...: :.||.:....||..:.
 Worm  1772 --VVSTLQSTVAELQD-RLKFQKEVIEKAEAELIETQEKYDELEQVYE-QSQQAQNSNKELIHVV 1832

  Fly  2168 TRDQSELEALRQSCQGHDETVR-IATLQQDNQQLE--LQQLRQAIIELETLRARDQTELEALRQS 2229
            ...:|::..::|.   .|:.:. :.|:|.:..:||  :|:|...|.|.|    :::|:.:.....
 Worm  1833 ENLKSQMGQIQQD---RDKLMTDLVTVQAEKLELEKIIQKLEVDIAEKE----QEKTDNDGWNDE 1890

  Fly  2230 SQGHDEAARIAIEQRDNQQLELQQLRQQLIELEALRARDQAELEALRQSCQGQQLSVDMASRNDE 2294
            ....|       :|::.:..:|.|||.:|          .|.:|.|.             |:...
 Worm  1891 DWRED-------DQKETESEKLTQLRNEL----------TARIEQLE-------------SQKSN 1925

  Fly  2295 QMAQLQEKESEIVHLKQRIEELMREDQTEKLVFEILTKNQELQLLRMQVKQLEEDKEDQQVSAAP 2359
            :.||:.||.|::..:|.:||:.:.|.:.|   .:.|.|  ||:|     |::|..|..:..:.|.
 Worm  1926 EQAQMSEKLSQVESMKVQIEQKLYETREE---LDDLKK--ELKL-----KEIELQKASEASTTAS 1980

  Fly  2360 PK--------DDGETVEKLKSLCQQLQQEKSDMEEEL-RVLNNHV-----LSSL---------EL 2401
            .:        |||| ::::|...:.|:.:...:::|| |:.:|.:     :|:|         ||
 Worm  1981 SEWNDDGWNDDDGE-IDRMKDTQKVLEMKVEALQDELQRLKDNEIELTETISALQSKLYDVQSEL 2044

  Fly  2402 EDRMKQTLLQLD------------TKN-IEITELRRSLE---------ILQSQNLGQN-----SA 2439
            || .||.|::.:            .|| .||.|::::||         |::.|||..|     ..
 Worm  2045 ED-TKQKLVEAENSASGWNDDDAWNKNENEIEEVKKALEIEISNRNDTIVKLQNLVSNLRQQLIE 2108

  Fly  2440 AEQIPDLSAINQQWEQLVEQKCGEVASIWQEHLSQREAAFKAQLEEVTQQQQR----------EL 2494
            |.:..||.:: ::.|||.|:.  .:.|.....|...||......:|...|..:          ::
 Worm  2109 ASESADLKSL-EELEQLKEEL--RIVSEQNGLLKDSEARLLDHADEFAVQMDKYREKCEVLTAKI 2170

  Fly  2495 PQSQQSTQGEATSDIMQKMQKALETQEMEIVTLKEQLAIRSAEYARLAAQYDPFRLQNRGGASGG 2559
            .:.:...|..|..|..||      |..:|:|.|::|||         .||.| .|:||
 Worm  2171 AELEAQLQNPAEEDQQQK------TSNVELVKLRQQLA---------NAQQD-MRVQN------- 2212

  Fly  2560 NPASTTVSAGGPPSLTANEP---LPEYVLKADLDYALMMLHQRDMRVEEMIVELVQLLEERDHLQ 2621
                          ||.::.   :.||            .||        |.|..:.:||. ||:
 Worm  2213 --------------LTISDREGLIAEY------------RHQ--------IAEQTKTIEEL-HLK 2242

  Fly  2622 LKLSDTLRQLETERSRVSDEPSATASSSAASSSSPSKISSAGS 2664
            ||......:..:.|..:|....|.:|..::..|:.|:||:|.|
 Worm  2243 LKTFSAAARRTSPRVPMSSNVPALSSRPSSRMSTSSRISTASS 2285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lva	NP_001284849.1	SMC_prok_B	327..1151	CDD:274008	180/855 (21%)
		SMC_prok_B	952..1721	CDD:274008	197/879 (22%)
		SMC_prok_B	1475..>2183	CDD:274008	166/774 (21%)
T28C6.7	NP_001294054.1	SMC_prok_B	260..1006	CDD:274008	218/1038 (21%)
		Smc	<1308..2058	CDD:224117	209/969 (22%)
		DUF342	<1940..2022	CDD:302792	23/92 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000