Protein Alignment lva and golg-4

DIOPT Version :9

• Sequence 1: NP_001284849.1
• Gene: lva / 31350
• FlyBaseID: FBgn0029688
• Length: 2779
• Species: Drosophila melanogaster
• Sequence 2: NP_001355507.1
• Gene: golg-4 / 175445
• WormBaseID: WBGene00010306
• Length: 1642
• Species: Caenorhabditis elegans
• Alignment Length: 2224
• Identity: 461/2224 - (20%)
• Similarity: 844/2224 - (37%)
• Gaps: 721/2224 - (32%)

  Fly   257 LIERLELSGAELQRTLTQRNEELE----QLRVVQAEE---DSLKVQENSRLQGEVLVLRERLAEL 314
            |..||:....:|:::..|..|:|.    |.|....|:   .......:.|..||   ..|..||
 Worm     5 LKNRLDNEAGKLKQSAQQYGEQLAAQVGQYRQAMNEQPAGSDASASISKRFTGE---SGETKAE- 65

  Fly   315 ENVNDLLETTRCELQEELTTARERQRNL-ELEQEQEKASRSPQSEAAHTDAQVSAELAKQLQELT 378
            ...|..:|::.. :..|:..|......| ..|....:..|||..::.|::   .:.||..||.:.
 Worm    66 NPANTSIESSSA-IMSEIPEADLLGLGLSSTESPSNRRRRSPSEDSIHSN---ESTLAALLQSIP 126

  Fly   379 NQLADLQATNEELRQQVAAQA--KLQVTDEIVSQRLEELEATIAAQLLELQEQKSAMAAQ---NE 438
            |.::....|.....:.||:.|  .....|...:.||::..||..|:..:...:.:.:...   ..
 Worm   127 NAISSALETIPSDSESVASDAFSVRSTNDPAYNSRLKQRLATYKAKYRDAVHRHNKLVDDVNTTR 191

  Fly   439 ELAEKTTE-----LNVLNVNLRLLEEKLAQSSRSKPLFLEDHSEDSAASKQMQEDLQQLKLKLDE 498
            :|.|.|.:     :..|.:..|:|.|||:.|           :.:....:::::..:..|..|::
 Worm   192 KLLETTQDECLQKVEKLRLEKRILAEKLSNS-----------AGNGDGKEELEKKCEDYKRMLEQ 245

  Fly   499 TNKANIKLKLKCKQAEKKLQKFQSQDGQQQLASLLADNE--------ELQQRIAVLEDEKGQWQL 555
                 .|:|:|..|.:||        .||||  :..||:        |::|||...|:|   | .
 Worm   246 -----CKIKIKSLQQDKK--------EQQQL--ITVDNDDSVDPRIREMEQRIQKTEEE---W-T 291

  Fly   556 ANMQEDDRQ----------PEQSTESNNPLQLETIR----LLEEQ----------KLELQQALEA 596
            ..:.|.|:|          ...:...|...::|..|    .||:|          |:|..||:..
 Worm   292 NRINESDQQHAINLATTKAEMHAALENKDSEIEQWRRKCATLEQQDADANQRWSDKVEKVQAMNK 356

  Fly   597 LLSSSSSAESIEIVERHHLECLGQRRPASEGDAQEQKQVHPPGPSHVSELTQTEQTEEEDSSGET 661
            .|.|    |..|::|:           .||..||        |...|.|..:.::||.|....:.
 Worm   357 ALES----EKNEMIEK-----------LSEAKAQ--------GVKAVLEEEERKRTEMETDLNDE 398

  Fly   662 LSQLRE-----RLELFT-------QERGEVLDKLEQLSAENLQLQA----------RLEESSSSL 704
            :.:|:|     |||:.|       :|..|..::.|.:.|..|:|.|          |:.|:|||.
 Worm   399 IERLKEETEKMRLEMSTYKVQLEAKESREFDEEREDVEALKLELNAVKSTRDDLESRITENSSSF 463

  Fly   705 QLLQREREKDLISSTSTSSNLSQELSSMQR-------SSEVVATLDAGEGGPVLFEKCEKSLSKL 762
            :..:.|.||.|.::.:....:..|....:.       :||.:||::        ||..|....::
 Worm   464 ENYRSEAEKTLAAAKAQFEKMVSECDKWREKYEERAAASEHIATVE--------FETQETDAHRI 520

  Fly   763 NSELEAYRKANDRQAKFNVSKKLAKEAKNCHTQLSELLHKVKEASTAVETVTVVETVVAVTAPNG 827
             .|.||.:||               .|:.|                  |.:|:
 Worm   521 -LEFEAEKKA---------------LAEKC------------------EELTL------------ 539

  Fly   828 KALAEYEQLNAQNAELKAVISRLRQELDELRESYPETEAPLAIVGSDSQREDEILQLQSQLEDAR 892
                ::||.:.:..|:...:|||:||:.|..::                       ||:::.:|:
 Worm   540 ----KFEQADKEKNEMVQQLSRLQQEMLEKCDA-----------------------LQAEVNEAK 577

  Fly   893 SLQAEQRQQIEEQVDQIKELRQTEAEQLQLVARQSAEITQLQLQSEQFDQLLNSKEMSHEKQLEQ 957
            :|    |::|:.:.|.:.:    :||::|....:|.::  |:.:.:.|:   |.||...|:||
 Worm   578 AL----REEIQAKYDDVTQ----KAERIQGELEESKKV--LESEKQAFE---NEKEQEREEQL-- 627

  Fly   958 QTRIRRELEARA-ESLEGELSILQTLVAEQKQQLIESVSESEHALNLKMLELQSAQEELRELRAK 1021
                     |:| |.|..|            |.:::.|::          :|:.::||:  |.|:
 Worm   628 ---------AKAMEKLNSE------------QNILDEVTK----------KLEQSEEEV--LAAR 659

  Fly  1022 EDPDQLREALRVSKSLVAQQVRELTSSQETVDALNQQIQEYQGLEHAHKEEQFKNRELREKLKKY 1086
            ....:|.|.|..|:...:....||.:..:.:|:....::|:.              ::.|.:|..
 Worm   660 GAIQELTEKLEESEKETSTAKTELEAVSKKLDSSETSLKEFS--------------DMIEAMKIQ 710

  Fly  1087 ALNLKKRTQDNADLEQKVQELTSQLQEQQELVKQK-EEVEREPIVDNHRVEQLQQQVSKLNEDLK 1150
            .:|.:|                 |..|..||:||| ||||:     |....::|:|:...:...:
 Worm   711 LINCEK-----------------QKDEAVELLKQKLEEVEK-----NMSDVEVQKQLLLESTTSE 753

  Fly  1151 AKIHLNLENRDALRQLKQQIQEQEQLIQ--ERDAELQ---------DANLVSKELRRERQEADQE 1204
            .|.|     .:|...:|:|::|.:..|:  ::|||.:         |.:....|:.::.:.|.:|
 Worm   754 MKQH-----AEAAEIVKKQLEEAQSSIENLKKDAENERNLKTALESDESSAISEITKQMEAAKKE 813

  Fly  1205 VFQLGQENSRLREEISKLQEEIHNLGQRVNEEPTAVEDLRRQLEAKSKKFEKSKELIKLRNATIQ 1269
            :....:|.|.|||::.:|| ::||.||.      .::.|::..|.:..|..||.|..||..   :
 Worm   814 LEASEKEKSELREQMDRLQ-KVHNAGQE------DIQKLQKTWELEMAKIAKSTEDEKLAR---E 868

  Fly  1270 SLQRELQQLQQDQD--SEVEH--VRNARAAHEQLRLEKDAEITALRQEILKLERSRAAGEGDDTI 1330
            .|..||:..::|..  .|.:|  ::.|:.|.:    :.:.|:..|:::   |||:::|.|...
 Worm   869 QLAGELENAKEDLKVVEEEKHTGIQRAQGALD----DAEKEVKVLKEQ---LERAQSALESSQ-- 924

  Fly  1331 TKTSHQLLESQSQQQAESLQVAERELQQLRVQLTAAQEQHALLAQQYASDKANFEMTIARLETLH 1395
                    |..|.|:|:.:|..|:|||.               ||:.:|
 Worm   925 --------ELASSQKADKIQELEKELQN---------------AQKRSS---------------- 950

  Fly  1396 EGIQAKLQEDASYIESLEAQNTELQARSAALEEQAASQANQQAASQDKVQILEQQLKEQREQEEQ 1460
                          |.||..|..:::.:|.||.           |..:.:||:|:| |..::|.|
 Worm   951 --------------EELETANEMVRSLTATLEN-----------SNSETEILKQKL-ETLDKELQ 989

  Fly  1461 KRQQDQQLQERFYELGQREQAQSRQLELLTSEAEESRQQLAGLRTEYESLLAKHSQLTATAQAER 1525
            .||             |.|:|.:.::.:||:...|..||                    |||.:.
 Worm   990 ARQ-------------QTEKALTEEINVLTTSLAEKEQQ--------------------TAQIQN 1021

  Fly  1526 EQMSSHSQEELAELRQQLDVKEADLHRQRQVYDAKLAAKATELDELECDLNSHVERAAAETRELC 1590
            .|...:..|  .|..:::::.:..|.:..|...:...|...|:::||..|.: ||:|.||.  |.
 Worm  1022 LQTQIYQME--VEKEEKVELVKVQLQQAAQSSSSAEEALRAEIEQLEAKLKA-VEQAKAEA--LN 1081

  Fly  1591 QQLERSQELVAQRTEELQRLNEEFQEVERERSTLSREVTLLRLQHDSAEQDVLELQELRMQAMQD 1655
            ..|...:.|.||    |.:|.     ||:|...   |:..::||                ||.|.
 Worm  1082 SLLAEKEHLQAQ----LHQLG-----VEKEEKL---EMVKVQLQ----------------QAAQS 1118

  Fly  1656 KTEMDNLRTQIDALCANHSQELQALQQRIAELDTLGQNQTDDQVYIETENKRLAEQLSELQAQLA 1720
            .:.::      .||.|    |::.|:.::.|::...:|..:..:   .|.::...|:.||||||
 Worm  1119 SSSVE------QALRA----EIEKLEAKLQEIEEEKKNALNASL---AEKEQQTAQIQELQAQL- 1169

  Fly  1721 RQQHQQQQQQHHHPAVQSQQHPPPASLFFGGDALAAPSPFDEIAQPLRVSSLAASAPPPISPPPT 1785
            .|...:::::.....||.||              ||.|. ..:.|.||..
 Worm  1170 HQLEVEKEEKLEMVKVQLQQ--------------AAQSS-SSVEQALRAE--------------- 1204

  Fly  1786 IEDLQRNVSDLEKHAQDLETKLLARNQNLAEQEERRLQLEQRLSE--------VERLLSERTQQL 1842
            ||.|:..:.::||          |:.||.:::|::..:| ..|:|        .|:::|:...:|
 Worm  1205 IEKLEAKLQEIEK----------AKMQNSSKREQKVREL-SNLNEKMRVEFIAKEKIISDLRSEL 1258

  Fly  1843 ADIQTANEERDRLAALEKLIQPAAAPTLDMFFGGQAEETVPDAVSHHLDLGLPQTEPVVEPLIQP 1907
            :.|.|           |.::|.|......|.||                          |...:.
 Worm  1259 STIST-----------ELVVQKATVEKTKMDFG--------------------------ELETRE 1286

  Fly  1908 KKAYLCQPKQEIQEQTAQTIDWGVDEDPWASAANEAPQTDVEHLHTRIAQLELQLSNAEQQKTEL 1972
            |:|...:..::::|...:                   :|..:.|.|..:.||::.:...:.|...
 Worm  1287 KRATADRENEKMEEIRLR-------------------ETFAKELETMGSALEVKETAYNELKASA 1332

  Fly  1973 QTKAAKLMKRLKEYKTKATTTATPTVTVDNDLDSTIIEELKHQLQLQESRLSKAEEISQQHALEK 2037
            :.|.|||..:.:|...||..:                     |.:..|||....|..::|..||.
 Worm  1333 EKKIAKLTSQFEEKLKKAQNS---------------------QDEASESRFKTLEASAEQAKLES 1376

  Fly  2038 E-KLAKRIDVLTAGNDRMAEMKERQ----------DMDVQMYQARIRELQEKLSQLDQWGE--PA 2089
            | ||....::|.:....:.|:|.::          :::.:|.:...:||.:::..|:...:  .|
 Worm  1377 EQKLRALEELLKSSESEIEELKIKEISAEKDRSHWEVEKEMLEGEAKELTDRIEGLEAEVKKLTA 1441

  Fly  2090 ATVSSSLDGDEAAR--IESLQQEIQQLRQQVSELEDERTRDQAELGALRQSSQGYDEAEDNQKLE 2152
            |..:.::..|..||  :..||:|::||..::::...:....|.||..|:.|.    |..:|.:|:
 Worm  1442 ANETKAVKADTDARKVVRELQKEVKQLYNELNDKNQQFDMVQEELTRLKTSK----ETAENGQLQ 1502

  Fly  2153 LQQLRQQESELEALRTRDQSELEALRQSCQGHDETVRIATLQQDNQQLELQQLRQAIIELETLR- 2216
            :|:...:|........:::                  ||:|:        |:|..::.|.:.||
 Worm  1503 VQKQMDEEDRRSEFSFKEE------------------IASLK--------QKLDASLTEADDLRM 1541

  Fly  2217 --ARDQTELEALRQSSQGHDEAARIAIEQRDNQQLELQQLRQQLIELEALRARDQAELEALRQSC 2279
              :|::....:...:|.|                      |.:.:||..:  .|.||.|.||...
 Worm  1542 QVSRNEKTPRSNGNASTG----------------------RTKSMELHGI--ADPAEAEYLRNVL 1582

  Fly  2280 QGQQLSVDMASRNDEQMAQLQEKESEIVHLKQRIEELMREDQTEKLVFEILTKNQELQLLRMQVK 2344
            .             ..|...:....|.|.|.:.|..:.|.|::                   |:|
 Worm  1583 Y-------------RYMTNRESLGKESVTLARVIGTVARFDES-------------------QMK 1615

  Fly  2345 QLEEDKEDQQVSAA 2358
            .:...:|.:|.|.|
 Worm  1616 NVISSEESRQASWA 1629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lva	NP_001284849.1	SMC_prok_B	327..1151	CDD:274008	187/897 (21%)
		SMC_prok_B	952..1721	CDD:274008	175/785 (22%)
		SMC_prok_B	1475..>2183	CDD:274008	146/730 (20%)
golg-4	NP_001355507.1	DUF3584	207..>884	CDD:378817	198/909 (22%)
		SMC_prok_B	577..1442	CDD:274008	257/1235 (21%)
		SH3_and_anchor	<1444..1549	CDD:275056	27/134 (20%)
		Grip	1572..1620	CDD:197860	14/79 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000