DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vap33 and VAPA

DIOPT Version :9

Sequence 1:	NP_570087.1	Gene:	Vap33 / 31349	FlyBaseID:	FBgn0029687	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_003565.4	Gene:	VAPA / 9218	HGNCID:	12648	Length:	294	Species:	Homo sapiens

Alignment Length:	290	Identity:	105/290 - (36%)
Similarity:	149/290 - (51%)	Gaps:	40/290 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTIEPEHELRFVGPFTRPVVTIMTLRNNSALPLVFKIKTTAPKRYCVRPNIGKIIPFRSTQVEIC 74
            |.::|..:|:|.||||..|.|.:.|||.|...:.||:|||||:|||||||.|.|.|..:..|.:.
Human    15 LVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVM 79

  Fly    75 LQPFVYDQQEKNKHKFMVQSVLAPMDADLSDLNKLWKDLEPEQLMDAKLKCVFEMPTAEANAENT 139
            ||||.||..||:|||||||::.||  .:.||:..:||:.:|::|||:||:||||||.     ||.
Human    80 LQPFDYDPNEKSKHKFMVQTIFAP--PNTSDMEAVWKEAKPDELMDSKLRCVFEMPN-----END 137

  Fly   140 SGGGAVGGGTGAAGGGSAGANT--SSASAEALESKPKLSSEDKFKPSNLLETSESLDLLSGE--- 199
            ..|....|........|:..||  :.||....:....||...:.|..|.:|.|:::.|.:.:
Human   138 KLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQKNDMEPSKAVPLNASKQDG 202

  Fly   200 ---------------IKALRECN------IELRRENLHLKDQITRFRSSPAVKQVNEPYAPVLAE 243
                           .|.:.||.      ::|..||.||:|:..|.|.   |...::|.:...|.
Human   203 PMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRK---VAHSDKPGSTSTAS 264

  Fly   244 KQ----IPVFYIAVAIAAAIVSLLLGKFFL 269
            .:    .|:..:.|.|||..:...||||.|
Human   265 FRDNVTSPLPSLLVVIAAIFIGFFLGKFIL 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vap33	NP_570087.1	Motile_Sperm	9..115	CDD:279029	53/104 (51%)
VAPA	NP_003565.4	Motile_Sperm	14..118	CDD:395510	53/104 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158291
Domainoid	1	1.000	113	1.000	Domainoid score	I6143
eggNOG	1	0.900	-	-		E1_COG5066
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4318
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332028at2759
OrthoFinder	1	1.000	-	-		FOG0000705
OrthoInspector	1	1.000	-	-		otm40462
orthoMCL	1	0.900	-	-		OOG6_101143
Panther	1	1.100	-	-	LDO	PTHR10809
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2279
SonicParanoid	1	1.000	-	-		X526
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790