DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vap33 and Vapa

DIOPT Version :9

Sequence 1:	NP_570087.1	Gene:	Vap33 / 31349	FlyBaseID:	FBgn0029687	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	XP_008765606.1	Gene:	Vapa / 58857	RGDID:	61803	Length:	290	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	106/297 - (35%)
Similarity:	151/297 - (50%)	Gaps:	58/297 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTIEPEHELRFVGPFTRPVVTIMTLRNNSALPLVFKIKTTAPKRYCVRPNIGKIIPFRSTQVEIC 74
            |.::|..:|:|.||||..|.|.:.|:|.|...:.||:|||||:|||||||.|.|.|.....|.:.
  Rat    15 LVLDPPSDLKFKGPFTDVVTTNLKLQNPSDRKVCFKVKTTAPRRYCVRPNSGVIDPGSIVTVSVM 79

  Fly    75 LQPFVYDQQEKNKHKFMVQSVLAPMDADLSDLNKLWKDLEPEQLMDAKLKCVFEMPTAEANAENT 139
            ||||.||..||:|||||||::.||  .::||:..:||:.:|::|||:||:||||||.     ||.
  Rat    80 LQPFDYDPNEKSKHKFMVQTIFAP--PNISDMEAVWKEAKPDELMDSKLRCVFEMPN-----END 137

  Fly   140 SGGGAVGGGTGAAGGGSAGANTSSASAE-ALESKPKLSSEDKFKPSNLLETSESLDLLSGE---- 199
            ..|..:.|...|....|:.::|.:..|. .::|.|:...|.|   .|.:|.|:::.|.:.:
  Rat   138 KLGKTLPGIASAVTSVSSISSTVATPASYHMKSDPRELKEVK---QNDMEPSKAVPLNASKQDGP 199

  Fly   200 --------------IKALRECN------IELRRENLHLKDQITRFR---------SSPAVK---Q 232
                          .|.:.||.      ::|..||.||:|:..|.|         |:.||.   .
  Rat   200 LPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSAVSFRDN 264

  Fly   233 VNEPYAPVLAEKQIPVFYIAVAIAAAIVSLLLGKFFL 269
            |..|...:|           |.|||..:...||||.|
  Rat   265 VTSPLPSLL-----------VVIAAIFIGFFLGKFIL 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vap33	NP_570087.1	Motile_Sperm	9..115	CDD:279029	52/104 (50%)
Vapa	XP_008765606.1	Motile_Sperm	14..118	CDD:279029	52/104 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352272
Domainoid	1	1.000	113	1.000	Domainoid score	I5972
eggNOG	1	0.900	-	-		E1_COG5066
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4232
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332028at2759
OrthoFinder	1	1.000	-	-		FOG0000705
OrthoInspector	1	1.000	-	-		otm44604
orthoMCL	1	0.900	-	-		OOG6_101143
Panther	1	1.100	-	-	LDO	PTHR10809
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X526
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760