DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vap33 and Vapb

DIOPT Version :9

Sequence 1:	NP_570087.1	Gene:	Vap33 / 31349	FlyBaseID:	FBgn0029687	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_062780.2	Gene:	Vapb / 56491	MGIID:	1928744	Length:	243	Species:	Mus musculus

Alignment Length:	263	Identity:	100/263 - (38%)
Similarity:	145/263 - (55%)	Gaps:	30/263 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTIEPEHELRFVGPFTRPVVTIMTLRNNSALPLVFKIKTTAPKRYCVRPNIGKIIPFRSTQVEIC 74
            |::||:|||:|.||||..|.|.:.|.|.:...:.||:|||||:|||||||.|.|....|..|.:.
Mouse     8 LSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGVIDAGASLNVSVM 72

  Fly    75 LQPFVYDQQEKNKHKFMVQSVLAPMDADLSDLNKLWKDLEPEQLMDAKLKCVFEMPTAEANAENT 139
            ||||.||..||:||||||||:.||  .|.||:..:||:.:||.|||:||:||||:|...|...:.
Mouse    73 LQPFDYDPNEKSKHKFMVQSMFAP--PDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENAKPHDV 135

  Fly   140 SGGGAVGGGTGAAGGGSAGANTSSASAEALESKPKLSSEDKFKPSNLLETSESLDLLSGEIKALR 204
            .....:        ..||....:.|:|::|.| |...:|.|       :..|....|.||::.||
Mouse   136 EINKII--------PTSASKTEAPAAAKSLTS-PLDDTEVK-------KVMEECRRLQGEVQRLR 184

  Fly   205 ECNIELRRENLHLKDQITRFRSSPAVKQVNEPYAPVLA---EKQIPVFYIAVAIAAAIVSLLLGK 266
            |.:.:|:.|     |.:...::.|:    |.|.|.:.|   |:.:....:|:.:...||.:::||
Mouse   185 EESRQLKEE-----DGLRVRKAMPS----NSPVAALAATGKEEGLSARLLALVVLFFIVGVIIGK 240

  Fly   267 FFL 269
            ..|
Mouse   241 IAL 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vap33	NP_570087.1	Motile_Sperm	9..115	CDD:279029	56/104 (54%)
Vapb	NP_062780.2	Motile_Sperm	8..111	CDD:279029	56/104 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848687
Domainoid	1	1.000	111	1.000	Domainoid score	I6243
eggNOG	1	0.900	-	-		E1_COG5066
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36163
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4332
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000705
OrthoInspector	1	1.000	-	-		otm42539
orthoMCL	1	0.900	-	-		OOG6_101143
Panther	1	1.100	-	-	O	PTHR10809
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2279
SonicParanoid	1	1.000	-	-		X526
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.780