DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vap33 and vapb

DIOPT Version :9

Sequence 1:	NP_570087.1	Gene:	Vap33 / 31349	FlyBaseID:	FBgn0029687	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_997812.1	Gene:	vapb / 323628	ZFINID:	ZDB-GENE-030131-2348	Length:	243	Species:	Danio rerio

Alignment Length:	265	Identity:	100/265 - (37%)
Similarity:	141/265 - (53%)	Gaps:	34/265 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTIEPEHELRFVGPFTRPVVTIMTLRNNSALPLVFKIKTTAPKRYCVRPNIGKIIPFRSTQVEIC 74
            |.:||:|||||.||||..|.|.:.|.|.:...:.||:|||||:|||||||.|.|....|..|.:.
Zfish     8 LLLEPQHELRFRGPFTDVVTTTLKLANPTDRNVCFKVKTTAPRRYCVRPNSGVIDAGTSINVSVM 72

  Fly    75 LQPFVYDQQEKNKHKFMVQSVLAPMDADLSDLNKLWKDLEPEQLMDAKLKCVFEMP-----TAEA 134
            ||||.||..||:||||||||:|||  .|::|...:|||.:||.|||:||:|||:||     |.|.
Zfish    73 LQPFDYDPNEKSKHKFMVQSLLAP--PDMTDTEGVWKDAKPEDLMDSKLRCVFDMPAENEKTHEM 135

  Fly   135 NAENTSGGGAVGGGTGAAGGGSAGANTSSASAEALESKPKLSSEDKFKPSNLLETSESLDLLSGE 199
            .:...|                   :.|.:.:..|..|...||.|..:...::|..:.|..   |
Zfish   136 ESNKIS-------------------SLSKSESSTLSMKSMASSMDDGEVKKIMEECKRLQT---E 178

  Fly   200 IKALRECNIELRRENLHLKDQITRFRSSPAVKQVNEPYAPVLAEKQIPVFYIAVAIAAAIVSLLL 264
            ::.|||.|.::|:|     |...|.|.|..:...:...|..:.|:.:....||:.:...:|.:::
Zfish   179 VQRLREENKQIRQE-----DDGLRMRKSTVMSAPHSSLAVRVKEEGLSSRVIALIVLFFVVGVIV 238

  Fly   265 GKFFL 269
            ||..|
Zfish   239 GKLAL 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vap33	NP_570087.1	Motile_Sperm	9..115	CDD:279029	58/104 (56%)
vapb	NP_997812.1	Motile_Sperm	8..111	CDD:279029	58/104 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594207
Domainoid	1	1.000	116	1.000	Domainoid score	I5915
eggNOG	1	0.900	-	-		E1_COG5066
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36163
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4213
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332028at2759
OrthoFinder	1	1.000	-	-		FOG0000705
OrthoInspector	1	1.000	-	-		otm24830
orthoMCL	1	0.900	-	-		OOG6_101143
Panther	1	1.100	-	-	O	PTHR10809
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2279
SonicParanoid	1	1.000	-	-		X526
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790