DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42541 and RRAD

DIOPT Version :9

Sequence 1:	NP_996345.3	Gene:	CG42541 / 31344	FlyBaseID:	FBgn0260658	Length:	1418	Species:	Drosophila melanogaster
Sequence 2:	NP_001122322.1	Gene:	RRAD / 6236	HGNCID:	10446	Length:	308	Species:	Homo sapiens

Alignment Length:	334	Identity:	86/334 - (25%)
Similarity:	119/334 - (35%)	Gaps:	121/334 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   875 GVGESSGASTSGTAIAELASSVVLATQSGKPMTERQRLRTS------------SMPAESRRPRLA 927
            |.|..:|.|..|                |:   ||:|.|.|            |||.:.|
Human     5 GGGSGAGGSRGG----------------GQ---ERERRRGSTPWGPAPPLHRRSMPVDER----- 45

  Fly   928 EMRRSAIHAGDPDMTYYRLRSFSITSHGICNLGDSLRSRRSRSINSVTSTGTSNSG------VDR 986
                                              .|::..:....:..:.||...|      .|.
Human    46 ----------------------------------DLQAALTPGALTAAAAGTGTQGPRLDWPEDS 76

  Fly   987 HNSNASGASGEVIDGDPNVPAYKIAMLGASGVGKTTLTYQFTTSDYICAYDLSLDDDYGQKTV-- 1049
            .:|.:||.|    |.|.:|  ||:.:|||.||||:.|...|.          .::|....:..
Human    77 EDSLSSGGS----DSDESV--YKVLLLGAPGVGKSALARIFG----------GVEDGPEAEAAGH 125

  Fly  1050 ----SVLVDNIETDLEIID------------HPACEMSTEAFCATYNIDLFVVVYSVIDRNTFAA 1098
                |::||..|..|.:.|            |          |.... |.:|:||||.|:.:|..
Human   126 TYDRSIVVDGEEASLMVYDIWEQDGGRWLPGH----------CMAMG-DAYVIVYSVTDKGSFEK 179

  Fly  1099 AERVLQYLKENEMLLSRGAILVANKTDLQRHRVVTRQMGRKVAKEIACKFIETSSGLDHNVDELL 1163
            |..:...|:..........|||.||:||.|.|.|:...||..|....|||||||:.|.|||..|.
Human   180 ASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALF 244

  Fly  1164 VGIVAQVKL 1172
            .|:|.|::|
Human   245 EGVVRQIRL 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42541	NP_996345.3	RGK	1008..>1175	CDD:206715	59/183 (32%)
CG42541	NP_996345.3	small_GTPase	1008..1171	CDD:197466	58/180 (32%)
RRAD	NP_001122322.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		25/144 (17%)
		RGK	92..308	CDD:206715	59/183 (32%)
		RAS	92..252	CDD:214541	58/180 (32%)
		Calmodulin-binding	278..297
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920