DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2930 and Slc15a2

DIOPT Version :9

Sequence 1:	NP_001284845.1	Gene:	CG2930 / 31341	FlyBaseID:	FBgn0028491	Length:	815	Species:	Drosophila melanogaster
Sequence 2:	NP_113860.2	Gene:	Slc15a2 / 60577	RGDID:	61972	Length:	740	Species:	Rattus norvegicus

Alignment Length:	762	Identity:	318/762 - (41%)
Similarity:	447/762 - (58%)	Gaps:	70/762 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 IAKKNGKEPDQNDKEPDQNGKELAETNDFKNVSETE------GQQKKLP-------YPKSVFFII 137
            :.::..|||..|..:.:::.:.|     |..||..|      ...||.|       ||.|:.||:
  Rat     2 LEERESKEPAMNPFQKNESKETL-----FSPVSTEEMLPRPPSPPKKSPPKIFGSSYPVSIAFIV 61

  Fly   138 SNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTIL 202
            .|||||||:||||:.||.||....|.:::||:|.|:|.|:...||..:.||.|:||||||||||:
  Rat    62 VNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYHAFSSLCYFTPILGAAIADSWLGKFKTII 126

  Fly   203 YLSLVYICGSVLLTLGAIGPLNLPM--ETFTMLGLALIALGSGGIKPCVSAFGGDQFKVPEQVKQ 265
            ||||||:.|.|..:||||..|...|  ...:::||:|||||:|||||||:|||||||: .|..:.
  Rat   127 YLSLVYVLGHVFKSLGAIPILGGKMLHTILSLVGLSLIALGTGGIKPCVAAFGGDQFE-EEHAEA 190

  Fly   266 ITSFFSLFYFSINAGSLISTTVTPILREDVSCFDDINCYPLAFGVPAVLMIVSVIIFVLGRSLYK 330
            .|.:||:||.:|||||||||.:||:||.||.||.. :||.||||||.:||::::::|.:|..:|:
  Rat   191 RTRYFSVFYLAINAGSLISTFITPMLRGDVKCFGQ-DCYALAFGVPGLLMVLALVVFAMGSKMYR 254

  Fly   331 MKPPAGNMVVLVSSTIWTALTTKCKEKKTN--PREHWLDYADKKYDRQLIDDVKVLMRVLFLYLP 393
            ..||.||:|..|...||.||..:.:.:..:  .|:||||:|.:||.:.||.|||.|.||||||:|
  Rat   255 KPPPEGNIVAQVIKCIWFALCNRFRNRSGDLPKRQHWLDWAAEKYPKHLIADVKALTRVLFLYIP 319

  Fly   394 LPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLNPLLILIFIPLYDVALYPALKLVGIR 458
            ||:||||.||||||||.||.:|:||:|.:.::|||:|||||.|:||||||:|:.:|..:....|.
  Rat   320 LPMFWALLDQQGSRWTLQANKMNGDLGFFVLQPDQMQVLNPFLVLIFIPLFDLVIYRLISKCRIN 384

  Fly   459 -RPLQKLTMGGILAGIAFIISGVVELSLEKTYPDLPYSQNIQLRIFNADNCDYFFTSNIPGAEN- 521
             ..|:|:.:|.|||.:||.::.:||..:.......|.||.|.|::.|..:.|...|  :.|:.|
  Rat   385 FSSLRKMAVGMILACLAFAVAALVETKINGMIHPQPASQEIFLQVLNLADGDVKVT--VLGSRNN 447

  Fly   522 -VTVTSLNAYTNKDIYA-----PGSLDVEFSLS----SASEACTISADKIPKVLTDNTAWSLFLN 576
             :.|.|::::.|...|:     ..|.|:.|.|.    |.....::......::|......|:...
  Rat   448 SLLVESVSSFQNTTHYSKLHLEAKSQDLHFHLKYNSLSVHNDHSVEEKNCYQLLIHQDGESISSM 512

  Fly   577 PLNGSGYYWEEDFVDKPSQSHPLIRNVANVPQELSIRWE---KASTGEVVYDDLASKTLLTRVNS 638
            .:..:|.        ||:.....||.:..:.::|:|..:   ..|.|: .|...|.:|:|.....
  Rat   513 LVKDTGI--------KPANGMAAIRFINTLHKDLNISLDTDAPLSVGK-DYGVSAYRTVLRGKYP 568

  Fly   639 A---EYVVMVGERNVGTFDVHTGGVYTLLIKDNNNIYEANLE----EVTSPNSVKILWLVPQYVV 696
            |   |....|...::|..|.  |..|..:|   .||....|:    |....|.:.|.|.:||||:
  Rat   569 AVHCETEDKVFSLDLGQLDF--GTTYLFVI---TNITSQGLQAWKAEDIPVNKLSIAWQLPQYVL 628

  Fly   697 MTLGEVMFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFGNVIVVVIAEAALFESQASEFFLFAGL 761
            :|..|||||||||||||:|||.||||||||.||||||.||:||:|:|:.:.. :|.:||.||:.|
  Rat   629 VTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLVVAQFSGL-AQWAEFVLFSCL 692

  Fly   762 MFADMLIFMVMAYYYVPNDPNKVEEAQPLTAGDAKTEIPALEGGVEN 808
            :....|||.||||||||.......||       ...:|||::|.:.|
  Rat   693 LLVVCLIFSVMAYYYVPLKSEDTREA-------TDKQIPAVQGNMIN 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2930	NP_001284845.1	2A1704	145..776	CDD:273343	284/656 (43%)
CG2930	NP_001284845.1	PTR2	198..504	CDD:279226	159/310 (51%)
Slc15a2	NP_113860.2	2A1704	69..707	CDD:273343	284/656 (43%)
Slc15a2	NP_113860.2	PTR2	122..441	CDD:279226	162/322 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	313	1.000	Domainoid score	I1257
eggNOG	1	0.900	-	-		E1_COG3104
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1279
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm9126
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740