DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2930 and Slc15a2

DIOPT Version :9

Sequence 1:	NP_001284845.1	Gene:	CG2930 / 31341	FlyBaseID:	FBgn0028491	Length:	815	Species:	Drosophila melanogaster
Sequence 2:	NP_067276.3	Gene:	Slc15a2 / 57738	MGIID:	1890457	Length:	740	Species:	Mus musculus

Alignment Length:	761	Identity:	305/761 - (40%)
Similarity:	448/761 - (58%)	Gaps:	68/761 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 IAKKNGKEPDQNDKEPDQNGKELAETNDFKNVSETE-------GQQKKLP------YPKSVFFII 137
            :.::..|||..|..:.:::.:.|     |..||..|       ..:|..|      ||.|:.||:
Mouse     2 LEERESKEPAMNPFQKNESKETL-----FSPVSTEEMLPGPPSPPKKSTPKLFGSSYPLSIAFIV 61

  Fly   138 SNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTIL 202
            .|||||||:||||:.||.||....|.:::||:|.|:|.|:...||..:.||.|:||||||||||:
Mouse    62 VNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYHAFSSLCYFTPILGAAIADSWLGKFKTII 126

  Fly   203 YLSLVYICGSVLLTLGAIGPLNLPM--ETFTMLGLALIALGSGGIKPCVSAFGGDQFKVPEQVKQ 265
            ||||||:.|.|..:||||..|...|  ...:::||:|||||:|||||||:|||||||: .|..:.
Mouse   127 YLSLVYVLGHVFKSLGAIPILGGKMLHTILSLVGLSLIALGTGGIKPCVAAFGGDQFE-EEHAEA 190

  Fly   266 ITSFFSLFYFSINAGSLISTTVTPILREDVSCFDDINCYPLAFGVPAVLMIVSVIIFVLGRSLYK 330
            .|.:||:||.||||||||||.:||:||.||.||.: :||.||||:|.:||::::::|.:|..:|:
Mouse   191 RTRYFSVFYLSINAGSLISTFITPMLRGDVKCFGE-DCYALAFGIPGLLMVLALVVFAMGSKMYR 254

  Fly   331 MKPPAGNMVVLVSSTIWTALTTKCKEKKTN--PREHWLDYADKKYDRQLIDDVKVLMRVLFLYLP 393
            ..||.||:|..|:..||.|:..:.:.:..:  .|:||||:|.:||.:.||.|||.|.|:||||:|
Mouse   255 KPPPEGNIVAQVTKCIWFAICNRFRNRSEDIPKRQHWLDWAAEKYPKHLIMDVKALTRILFLYIP 319

  Fly   394 LPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLNPLLILIFIPLYDVALYPALKLVGIR 458
            ||:||||.||||||||.||.:||||:|.:.::|||:|||||.|:|:||||:|:.:|..:...|:.
Mouse   320 LPMFWALLDQQGSRWTLQANKMDGDLGFFVLQPDQMQVLNPFLVLVFIPLFDLVIYRLISKCGVN 384

  Fly   459 -RPLQKLTMGGILAGIAFIISGVVELSLEKTYPDLPYSQNIQLRIFNADNCDYFFTSNIPGAEN- 521
             ..|:|:.:|.|||.:||.::.:||:.:.......|.||.|.|::.|..:.:...|  :.|..|
Mouse   385 FSSLRKMAVGMILACLAFAVAALVEIKINGMIHPQPASQEIFLQVLNLADGEIEVT--VQGNRNN 447

  Fly   522 -VTVTSLNAYTNKDIYA-----PGSLDVEFSLS----SASEACTISADKIPKVLTDNTAWSLFLN 576
             :.|.|::::.|...|:     ..|.|:.|.|.    |.....::......:::......||...
Mouse   448 PLLVESISSFQNTTHYSKLRLETKSQDLHFHLKYNNLSVHNEYSVEEKNCYQLVVHENGESLSSM 512

  Fly   577 PLNGSGYYWEEDFVDKPSQSHPLIRNVANVPQELSIRWEKASTGEVVYDDLASKTLLTRVNSAEY 641
            .:..:|.        ||:.....||.:..:.::::|..:..:...|..|...|:  ...|...:|
Mouse   513 LVKDTGI--------KPANGMTAIRFINTLHKDMNISLDANAPLSVGKDYGVSE--YRTVQRGKY 567

  Fly   642 VVM-------VGERNVGTFDVHTGGVYTLLIKDNNNIYEANLEEVTSPNSVKILWLVPQYVVMTL 699
            ..:       |...|:|..|..|..::.:....|..:.....|::.: |.:.|.|.:||||::|.
Mouse   568 PAVHCETEDNVFSLNLGQLDFGTTYLFVITNITNRGLQAWKAEDIPA-NKLSIAWQLPQYVLVTA 631

  Fly   700 GEVMFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFGNVIVVVIAEAALFES--QASEFFLFAGLM 762
            .|||||||||||||:|||.||||||||.||||||.||:||:::|:   |..  |.:||.||:.|:
Mouse   632 AEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLIVAQ---FSGLVQWAEFVLFSCLL 693

  Fly   763 FADMLIFMVMAYYYVPNDPNKVEEAQPLTAGDAKTEIPALEGGVEN 808
            ....|||.||.|||||.....:.||       .:.:||.::|.:.|
Mouse   694 LVVCLIFSVMGYYYVPLKSEGIHEA-------TEKQIPHIQGNMIN 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2930	NP_001284845.1	2A1704	145..776	CDD:273343	273/655 (42%)
CG2930	NP_001284845.1	PTR2	198..504	CDD:279226	157/310 (51%)
Slc15a2	NP_067276.3	2A1704	69..707	CDD:273343	273/655 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	320	1.000	Domainoid score	I1232
eggNOG	1	0.900	-	-		E1_COG3104
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1296
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm8880
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1031
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770