DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2930 and slc15a4

DIOPT Version :9

Sequence 1:	NP_001284845.1	Gene:	CG2930 / 31341	FlyBaseID:	FBgn0028491	Length:	815	Species:	Drosophila melanogaster
Sequence 2:	NP_001307458.1	Gene:	slc15a4 / 393932	ZFINID:	ZDB-GENE-040426-1047	Length:	578	Species:	Danio rerio

Alignment Length:	761	Identity:	161/761 - (21%)
Similarity:	277/761 - (36%)	Gaps:	281/761 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GKELAETNDFKNVSETEGQQKKLPYPKSVF--------FIISNEFCERFNYYGMRTVLVLYLSRV 161
            |:::.|::.....|.|..:.      :|||        .|:..|..||..:||:.:.|||:|:..
Zfish     3 GRDINESSPLLENSVTSTRS------ESVFNGRRLACAAILLAESLERMAFYGITSNLVLFLNSS 61

  Fly   162 LGYSDDT-ATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTI-----LYL-------------SLV 207
            ..|.:.| |:....||....|.:..||..::|::||||.||     |||             :..
Zfish    62 PFYWEGTLASQGPLIFMGVTYLISPFGGWLADAYLGKFLTIALSLGLYLLGMLLFPFVASDNTRN 126

  Fly   208 YICGSVLLTLGAIGPLNLPMETF----------------------TMLGLALIALGSGGIKPCVS 250
            |:||..:..     |:. |.|.|                      ...||.|:|||.|.:|..::
Zfish   127 YLCGEEMAF-----PVQ-PAECFPENGTVPANVTCVNRPSYCRPAIYSGLVLVALGVGAVKSNIT 185

  Fly   251 AFGGDQFK--VPEQVKQITSFFSLFYFSINAGSLISTTVTPILREDVSCFDDINCYPLAFGVPAV 313
            .||.||.|  .||..::   ||:.||:.||.|::.|......:::::|       :.:.:.:|||
Zfish   186 PFGADQVKDRGPEATRR---FFNWFYWCINLGAIFSLGGIAYIQQNIS-------FSIGYIIPAV 240

  Fly   314 LMIVSVIIFVLGRSLYKMKPPAGNMVVLVSSTIWTALTTKCKEKKT--NPREHWLDYADKKY--- 373
            .:.||:|||.||::::..||..|:....:...:.:||..:..::.:  .|:...||.|...|
Zfish   241 CLGVSLIIFFLGKAVFITKPADGSAFSDMFRILGSALCGRGPKEPSLLRPKPTVLDGAKVTYGGR 305

  Fly   374 -DRQLIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRM---DGDMGSWDIKPDQ------ 428
             ..:.:::||.|:::|.::|.|..:|.::.|..:.:..|:..:   ..|..|.|..|:.
Zfish   306 FSDEKVEEVKSLVKILPVFLALIPYWTVYFQMQTTYYLQSLHLTIPGADPNSTDSHPNTFRFPAA 370

  Fly   429 -LQVLNPLLILIFIPLYDVALYPALKLVGIRRPLQKLTMGGILAGIAFIISGVVELSLEKTYPDL 492
             |.:.:.:|||:.|||.|..:.|.||    |:.|...::..|..|:.|::...|...:.:|
Zfish   371 WLTMFDAVLILMLIPLKDKVVDPILK----RKGLLPSSLKRIAVGMFFVMCSAVAAGILET---- 427

  Fly   493 PYSQNIQLRIFNADNCDYFFTSNIPGAENVTVTSLNAYTNKDIYAPGSLDVEFSLSSASEACTIS 557
                                                          ..||:
Zfish   428 ----------------------------------------------KRLDI-------------- 432

  Fly   558 ADKIPKVLTDNTAWSLFLNPLNGSGYYWEEDFVDKPSQSHPLIRNVANVPQELSIRWEKASTGEV 622
                                                      :|....:||.|         |.|
Zfish   433 ------------------------------------------VRTRGPIPQSL---------GGV 446

  Fly   623 VYDDLASKTLLTRVNSAEYVVMVGERNVGTFDVHTGGVYTLLIKDNNNIYEANLEEVTSPNSVKI 687
            :|                                               |.|:|         .|
Zfish   447 IY-----------------------------------------------YAADL---------PI 455

  Fly   688 LWLVPQYVVMTLGEVMFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFGN-----VIVVVIAEAAL 747
            .|.|||||::.:.|:..|:.||||:|:.||.||:|.:...:......|:     ::.:|..:|..
Zfish   456 WWQVPQYVLIGVSEIFASIAGLEFAYSAAPRSMQSAIMGLFFFFSGIGSFVGSGLLAIVSLKAIG 520

  Fly   748 FESQASE------------FFLFAGLMFADMLIFMVMAYYYVPNDP 781
            :.|...:            |||.|.:....:|||::::..|....|
Zfish   521 WMSSHQDFGNINECRLNYYFFLLAAIQGITLLIFLIVSVKYDKQKP 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2930	NP_001284845.1	2A1704	145..776	CDD:273343	148/706 (21%)
CG2930	NP_001284845.1	PTR2	198..504	CDD:279226	88/363 (24%)
slc15a4	NP_001307458.1	MFS	158..522	CDD:304372	109/548 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D365203at2759
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830