DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2930 and pept-2

DIOPT Version :9

Sequence 1:	NP_001284845.1	Gene:	CG2930 / 31341	FlyBaseID:	FBgn0028491	Length:	815	Species:	Drosophila melanogaster
Sequence 2:	NP_502002.1	Gene:	pept-2 / 177973	WormBaseID:	WBGene00003876	Length:	785	Species:	Caenorhabditis elegans

Alignment Length:	782	Identity:	273/782 - (34%)
Similarity:	405/782 - (51%)	Gaps:	137/782 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 YPKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDS 193
            :||..|.|:.||.||||::||||.||.||...:|.:|...:||:||.||:..|...:.|:|::|.
Worm    30 WPKQTFLIVGNELCERFSFYGMRAVLTLYFFNILNFSQSFSTVLFHAFTVICYSSPLLGSILADG 94

  Fly   194 WLGKFKTILYLSLVYICGSVLLTLGAIGP---LNLPMETFTMLGLALIALGSGGIKPCVSAFGGD 255
            ::|||.||.::|:.|.||.:||...:|.|   .:.|:  ..:|||.::.||:|||||||||||||
Worm    95 YIGKFWTIFFISIFYACGQILLAFSSIAPSGSSHHPL--LDLLGLLIVGLGTGGIKPCVSAFGGD 157

  Fly   256 QFKVPEQVKQITSFFSLFYFSINAGSLISTTVTPILREDVSCFDDINCYPLAFGVPAVLMIVSVI 320
            ||.. ...:.|:.|||:||||||||||||..:||..| .:|||...:|||||||:||:||||:.:
Worm   158 QFPA-HYTRMISLFFSMFYFSINAGSLISMWLTPYFR-SMSCFGHDSCYPLAFGIPAILMIVATL 220

  Fly   321 IFVLGRSLYKMKPPAGNMVVLVSSTIWTALTTKCKEKKTNPREHWLDYADKKYD----------- 374
            :|:.|...||..||..|::..|..||.|||..|.....|:.|.|||:|:...:|
Worm   221 VFMAGSFWYKKVPPKENIIFKVIGTITTALRKKASSSSTHQRSHWLEYSLDGHDCALSTECKNLH 285

  Fly   375 -----RQLIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLNP 434
                 |:.|:|:|.|.||:.:.:|:|:||||:|||||.|..||..||..:..::|.|||:.|||.
Worm   286 GNCAQRRYIEDIKRLFRVIVMMIPVPMFWALYDQQGSTWVLQAVGMDAKVFGFEILPDQMGVLNA 350

  Fly   435 LLILIFIPLYDVALYPALKLVGIRRP-LQKLTMGGILAGIAFIISGVVELSLEKTYPDLPYSQNI 498
            .|||.|||::...:||.::.:|.:.. |:|:..||||..::|.:.|:|:|.:..|.|.:|.:...
Worm   351 FLILFFIPIFQSIVYPTIEKLGFQMTMLRKMAGGGILTAVSFFVCGIVQLFVNPTLPYIPMANEA 415

  Fly   499 QLRIFNA-DNCDY--FFTSNIPG--------AENVTVTSLNAYTNKDIYAPGSLDVEFSLSSASE 552
            .|.|.|. .:||:  ...|..|.        |.:.:|....::|..|.:.|     ..:..:.:.
Worm   416 HLTIINTIPSCDFNVLIDSREPFDLLRKSGIAPDDSVRKPISFTGDDFFQP-----NITFDNLAP 475

  Fly   553 ACTISADKIPK-----VLTDNTAWSLFLNPLNGSGYYWEEDFV--DKP-------SQSHPLIRNV 603
            .|       ||     :|...|::.|.|:| ||    |..:.|  :||       |....||...
Worm   476 NC-------PKFTAEPMLAPATSYVLTLSP-NG----WAYNAVRPEKPKSGKGELSMGLNLIVPC 528

  Fly   604 ANVPQELSIRWEKAS--------------TGEVVYD-------------------------DLAS 629
            ..:|.  ::.||:.:              ..:|:.|                         |.:.
Worm   529 DKIPS--NVTWEQCNGTEGYSGAIALCKVESDVITDNNNVCDPTAKGKFYVLSNANPLDVHDFSK 591

  Fly   630 KTLLTRVNSAEYVVMVGERNVGTFDV---------------------HTGGVYTLLI---KDNNN 670
            |:.:|........:   |...||:.:                     |.||.|.:.:   ..|::
Worm   592 KSTVTAFGRTYSPI---EMKPGTYRLFYTDDSRTHFTPLNLPPVQQDHMGGQYLITVSTRSKNDS 653

  Fly   671 IYEANLEEVTSPNSVKILWLVPQYVVMTLGEVMFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFG 735
            ...|..|.:.|.|.|.|||.:||||::|.|||:||:|||||:|.:|.|.:|||:||.||.|.|.|
Worm   654 EVLATTESLVSYNRVSILWQIPQYVILTAGEVLFSITGLEFAYTEASPQLKSVVQALWLFTTAIG 718

  Fly   736 NVIVVVIAEAALFESQASEFFLFAGLMFADMLIFMVMA-YYYVPNDPNKVEE--AQPLTAGDAKT 797
            ::|||||....:|...|.:.|:|.|:|...:.:|:::| :||...|.:...|  .:.:...|..|
Worm   719 DLIVVVIFMLNIFSDVAVQMFVFGGIMLFVIFVFILLAVFYYEYADYSNESEVLTEKMIVDDDHT 783

  Fly   798 EI 799
            .|
Worm   784 RI 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2930	NP_001284845.1	2A1704	145..776	CDD:273343	257/739 (35%)
CG2930	NP_001284845.1	PTR2	198..504	CDD:279226	142/325 (44%)
pept-2	NP_502002.1	2A1704	46..759	CDD:273343	257/738 (35%)
		PTR2	99..494	CDD:279226	157/410 (38%)
		MFS	<666..721	CDD:304372	33/54 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I930
eggNOG	1	0.900	-	-		E1_COG3104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38006
Inparanoid	1	1.050	466	1.000	Inparanoid score	I851
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		otm14792
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	1	1.100	-	-	O	PTHR11654
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1031
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.910