DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2930 and slc15a1

DIOPT Version :9

Sequence 1:	NP_001284845.1	Gene:	CG2930 / 31341	FlyBaseID:	FBgn0028491	Length:	815	Species:	Drosophila melanogaster
Sequence 2:	XP_012813171.2	Gene:	slc15a1 / 100145353	XenbaseID:	XB-GENE-987154	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	721	Identity:	300/721 - (41%)
Similarity:	442/721 - (61%)	Gaps:	59/721 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 QKKLP----YPKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLC 184
            :||.|    ||.|:|||:.|||||||:|||||.|||||....|.:.|:.|||::|.|....|...
Frog    20 EKKQPGCFGYPLSIFFIVINEFCERFSYYGMRAVLVLYFKYFLHWDDNLATVIYHTFVAICYLTP 84

  Fly   185 VFGAIISDSWLGKFKTILYLSLVYICGSVLLTLGAI----------GPLNLPME-TFTMLGLALI 238
            :.||||:||||||||||:|||:||..|.|::.:.||          .|..|.:. ..:::||.||
Frog    85 ILGAIIADSWLGKFKTIVYLSIVYTVGQVVMAVSAIHDLTDGNRDGTPDTLEVHVALSVIGLLLI 149

  Fly   239 ALGSGGIKPCVSAFGGDQFKVPEQVKQITSFFSLFYFSINAGSLISTTVTPILR-EDVSCFDDIN 302
            |||:|||||||:|||||||: ..|.||.:.|||:||.|||||||:||.:||||| ::........
Frog   150 ALGTGGIKPCVAAFGGDQFE-ENQDKQRSQFFSIFYLSINAGSLLSTIITPILRGQECGIHSQQK 213

  Fly   303 CYPLAFGVPAVLMIVSVIIFVLGRSLYKMKPPAGNMVVLVSSTIWTALTTKCKEK-KTNP-REHW 365
            ||||||||||.||:|::::|::|.|:||...|.||::|.||..|..|:..:.:.: |:.| ||||
Frog   214 CYPLAFGVPAALMVVALVVFIVGSSMYKKVSPQGNIIVKVSKCIGFAIRNRYRNRSKSIPKREHW 278

  Fly   366 LDYADKKYDRQLIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQ 430
            ||:|.:|||.:||..:|::::|||||:|||:|||||||||||||.|||.|||:.|:..|:|||:|
Frog   279 LDWAKEKYDERLIAQIKMVLKVLFLYIPLPMFWALFDQQGSRWTLQATTMDGNFGAIQIQPDQMQ 343

  Fly   431 VLNPLLILIFIPLYDVALYPALKLVGIR-RPLQKLTMGGILAGIAFIISGVVELSLEKTYPDLPY 494
            .:||:||::.:|::|.|:||.::...:. .||:::|:|..||.:||:.:.:|::.::||.|..|.
Frog   344 TVNPILIIVLVPIFDAAVYPLIRKCKLDFTPLKRMTVGMFLAAMAFVAAALVQIEIDKTLPTFPS 408

  Fly   495 SQNIQLRIFNADNCDYFFTSNIPGAENVTVTSLNAYTNKDIYAPGSLDVEFSLSSASEACTISAD 559
            |...||::.|.            |.:::.||.:....:..:..|...:...:|..:|........
Frog   409 SNEFQLKVINL------------GTKDLNVTYVANTADSALIPPFKANEYHTLEQSSSVTFAYGT 461

  Fly   560 KIPKV-----LTDNTAWSLFLNPLNGSGYYWE--EDFVDKPSQSHPLIRNVANVPQELSIRWEKA 617
            ..|:.     |.:.|.::..:.. :|:.....  ||...||.|....||.|..:.:.:::.....
Frog   462 NTPQPFPLQDLAEQTRYTCVVKD-DGTAIQANVFEDISAKPDQGSNAIRFVNGMQEPINVTLNAV 525

  Fly   618 STGEVVYDDLASKTLLTRVNSAEYVVMVGERNVGTFDVHT-----GGVYTLLIKDNNNIYEANLE 677
            |.|:::...:::.| :.::...|..|......  |:.|.:     |..||::||:.|...:....
Frog   526 SLGQLMPLQISNYT-MQKLGIKEIEVFTASGK--TWKVESIKFGFGSSYTIIIKEGNTELQVEYV 587

  Fly   678 EVTSPNSVKILWLVPQYVVMTLGEVMFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFGNVIVVVI 742
            |...||::.:...:|||.::|.|||:||||||||||:|||.:|||||||.||||||.||:||:::
Frog   588 EDIQPNTIHMALQIPQYFLITAGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV 652

  Fly   743 AEAALFESQASEFFLFAGLMFADMLIFMVMAYYYVPNDPNKV-----EEAQPLTAGDAKTEIPAL 802
            |.|:....|.:|:.|||.|:.|..:||.||||:|...||.::     ||.:...|    .||.|:
Frog   653 AGASHISQQWAEYVLFAALLVAVCIIFAVMAYFYTYVDPAEIEAQFDEEEKKKNA----KEIEAM 713

  Fly   803 EGGVEN 808
              ||:|
Frog   714 --GVQN 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2930	NP_001284845.1	2A1704	145..776	CDD:273343	273/657 (42%)
CG2930	NP_001284845.1	PTR2	198..504	CDD:279226	157/320 (49%)
slc15a1	XP_012813171.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1261
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H38006
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1196
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm9543
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970