DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2930 and slc15a1a

DIOPT Version :9

Sequence 1:	NP_001284845.1	Gene:	CG2930 / 31341	FlyBaseID:	FBgn0028491	Length:	815	Species:	Drosophila melanogaster
Sequence 2:	XP_021334489.1	Gene:	slc15a1a / 100004272	ZFINID:	ZDB-GENE-091204-9	Length:	717	Species:	Danio rerio

Alignment Length:	735	Identity:	291/735 - (39%)
Similarity:	428/735 - (58%)	Gaps:	62/735 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 VSETEGQQKKLP----YPKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFT 177
            :.||:.::||..    ||.|:|||:.|||||||:|||||.|||||....|.........::|.|.
Zfish     6 MDETKKKKKKTAECCGYPISIFFIVVNEFCERFSYYGMRAVLVLYFRYFLXXXXXXXXXIYHAFV 70

  Fly   178 MFVYFLCVFGAIISDSWLGKFKTILYLSLVYICGSVLLTLGAI----------GPLNLPME-TFT 231
            ...|...:.||||:||||||||||:|||:||..|.|::.:..|          .|.|..:. ..:
Zfish    71 ALCYLTPILGAIIADSWLGKFKTIIYLSIVYAVGQVVMAVSTIHDITDANRDGTPDNFTLHIALS 135

  Fly   232 MLGLALIALGSGGIKPCVSAFGGDQFKVPEQVKQITSFFSLFYFSINAGSLISTTVTPILR-EDV 295
            ||||.|||||:|||||||:|||||||: ..|.:|:.:|||:||..||||||:||.:||:|| ::.
Zfish   136 MLGLVLIALGTGGIKPCVAAFGGDQFQ-EHQSRQLNTFFSVFYLCINAGSLLSTLITPVLRAQEC 199

  Fly   296 SCFDDINCYPLAFGVPAVLMIVSVIIFVLGRSLYKMKPPAGNMVVLVSSTIWTALTTKCKEKKT- 359
            .......||||||||||.||:||:::|:.|..:|....|.||::..|...||.||..:.:.:..
Zfish   200 GIHTQQQCYPLAFGVPAALMVVSLVVFIAGSGMYTKTAPEGNIMGSVCKCIWFALNNRFRHRSDI 264

  Fly   360 -NPREHWLDYADKKYDRQLIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWD 423
             ..||||:|:|::|||:.||..:|::::|||||:|||:||.||||:|||||.|||.|.||.|.:.
Zfish   265 YPKREHWMDWAEEKYDKLLIAQIKMVLKVLFLYIPLPMFWTLFDQKGSRWTLQATTMTGDFGGFV 329

  Fly   424 IKPDQLQVLNPLLILIFIPLYDVALYPALKLVGIR-RPLQKLTMGGILAGIAFIISGVVELSLEK 487
            ::|||:|.:||:|||..:|:.|..::|.:|..|:. .||:::|:|.:.|..|||.:.:|::.::|
Zfish   330 LQPDQMQTVNPILILTLVPIMDRIIFPLIKKCGLNFSPLKRMTVGMLFAATAFIAAALVQMEIDK 394

  Fly   488 TYPDLPYSQNIQLRIFNADNCDYFFTSNIPGAENVTVTSLNAYTNKDIYAPGSLDVEFSLSSASE 552
            |.|:.|.|...||::.|..:.....|  :|..|.:.:.|..  ::.|.......|:..:.::..|
Zfish   395 TLPNFPSSSESQLKVVNMHSESLIVT--VPSQEPLLIGSFE--SSPDYITFDQQDIRLAFNTTPE 455

  Fly   553 ACTISADKIPKVLTDNTAWSLFLNPLNGSGYYWEEDFVDKPSQSHPLIR---------NVANVPQ 608
               |:.|   ..|...:..:|.: |...:..|.:||...||.:....:|         |:.|:
Zfish   456 ---INKD---LSLIKGSRQTLII-PSEPAEMYLKEDIKSKPKEGKNAVRFVNGWTAYLNITNL-- 511

  Fly   609 ELSIRWEKASTGEVVYDDLASKTLLTRVNSAEYVVMVGERNVGTFDVHTGGVYTLLIKDNNNIYE 673
            |.|::..:.|...:|...:...||...:.|.|:     .|..|     .|..||.||.  ::::.
Zfish   512 ESSLQPSETSNYTLVSQGMRKFTLTDGIQSCEF-----SRKFG-----FGSSYTFLIP--SDLFS 564

  Fly   674 ANLEEV-----TSPNSVKILWLVPQYVVMTLGEVMFSVTGLEFSYAQAPPSMKSVLQACWLLTVA 733
            .:.|.:     ..||||.:...:|||.::|.||||||||||:|||:|||.:|||||||.||.|.|
Zfish   565 TDCESIKEIEDMQPNSVHMALQIPQYFLITTGEVMFSVTGLQFSYSQAPKNMKSVLQAGWLCTNA 629

  Fly   734 FGNVIVVVIAEAALFESQASEFFLFAGLMFADMLIFMVMAYYYVPNDPNKVEE---AQPLTAGDA 795
            .||:||:::||......|.:|:.|||.|:.|..:||.:|||:|...||.::|.   .|..|..|.
Zfish   630 VGNIIVLIVAELGKLPKQWAEYVLFASLLVAVSIIFSIMAYFYTYIDPAEIEAEILKQQETDPDK 694

  Fly   796 KTEIPALEGGVENKGKDINE 815
            |.:...||...:...::|.:
Zfish   695 KKKKETLEMEEKENEQEIKQ 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2930	NP_001284845.1	2A1704	145..776	CDD:273343	264/659 (40%)
CG2930	NP_001284845.1	PTR2	198..504	CDD:279226	149/320 (47%)
slc15a1a	XP_021334489.1	PTR2	38..672	CDD:333212	264/659 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38006
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1211
OMA	1	1.010	-	-		QHG55282
OrthoDB	1	1.010	-	-		D246723at33208
OrthoFinder	1	1.000	-	-		FOG0000101
OrthoInspector	1	1.000	-	-		mtm6421
orthoMCL	1	0.900	-	-		OOG6_100318
Panther	1	1.100	-	-	O	PTHR11654
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X63
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980